Search Results - nanoparticle

67 Results

Sort By:

Utilize lipid nanoparticle-based CRISPR/Cas9 genome editing to delete the Pfkp gene for the treatment of head and neck cancer

This technology introduces a novel lipid nanoparticle-based CRISPR/Cas9 system designed to target the Pfkp gene for the effective treatment of head and neck cancer. Background: Head and neck cancer continues to pose a significant clinical challenge due to its aggressive nature and poor patient prognosis. A primary contributing factor is the overexpression...

Published: 6/22/2026 | Updated: 6/21/2026 | Inventor(s): Yamin Li

Keywords(s): cancer, cancer therapy, lipids, nanoparticle, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics and Vaccines

Biomimetic HDL Nanoparticles for Treatment of Cancer, Immune and Inflammatory Disorders, and Cardiovascular Disease

SHORT DESCRIPTION Self-assembling biomimetic high-density lipoprotein nanoparticle (HDL NP) platform technology with a soft organic core, designed to more closely replicate key functional properties of mature human HDL for therapeutic use in cardiovascular disease, cancer, and inflammatory/immune disorders. INVENTORS Colby Thaxton* Northwestern...

Published: 6/16/2026 | Updated: 6/16/2026 | Inventor(s):

Keywords(s): Atherosclerosis, Autoimmune disease, BIO2026, Breast cancer, Cancer/Oncology, Cardiology and Cardiovascular disease, Gene therapy, Immunology, Immunotherapy, Inflammation, Nanomaterials, Nanoparticle, Nanotechnology, Nucleic Acids, Platform technology, Prostate cancer, Research tool, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics

Development of novel liver-targeting glucocorticoid prodrugs

This technology presents novel liver-targeting glucocorticoid prodrugs designed to improve the treatment of inflammatory liver diseases and sepsis with enhanced efficacy and reduced systemic side effects. Background: Inflammatory liver diseases and sepsis represent significant clinical challenges due to their complex immune responses and the difficulty...

Published: 6/12/2026 | Updated: 6/11/2026 | Inventor(s): Hong Lu, Juntao Luo, Dandan Guo

Keywords(s): glucocorticoid, inflammatory liver disease, liver-selective, nanoparticle, prodrug, sepsis, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery

Assembly of Vaccines Using Cell-Free Integration of Viral Membrane Proteins into Liposomes

SHORT DESCRIPTION A cell-free method that assembles vaccines by integrating viral membrane proteins into liposomes, enabling rapid prototype production without cold chain requirements. INVENTORS Neha Kamat* McCormick School of Engineering, Department of Biomedical Engineering Hector Aguilar-Carreno Susan...

Published: 6/16/2026 | Updated: 6/10/2026 | Inventor(s):

Keywords(s): BIO2026, Immunology, Infectious disease, Nanomaterials, Nanoparticle, Nanotechnology, Synthetic biology, Vaccine

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools

High Sensitivity and Specificity Biosensor

This sensor architecture enables signal amplification for detection of biomarkers and analytes at extremely low concentration Background Molecular diagnostics increasingly rely on sensitive detection of biomarkers such as nucleic acids, proteins, and cytokines in complex biological samples. Traditional biosensor probes often suffer from signal...

Published: 5/9/2026 | Updated: 5/9/2026 | Inventor(s): Li-Jing Cheng, Ye Liu

Keywords(s): analyte, assay, biomarkers, biosensor, diagnostic, immunoassay, magnetic nanoparticles, molecular diagnostics, molecular probe, multiplexed detection, nanoparticle, nanoparticles, plasmonics, raman system, sensor, signal amplification

Category(s): Diagnostics

Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance

SHORT DESCRIPTION A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance. INVENTORS Edward Thorp* Northwestern University Feinberg School of Medicine, Department of Pathology Evan Scott* McCormick School of Engineering, Department...

Published: 6/16/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): BIO2026, Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation

Category(s): Life Sciences > Therapeutics

Northwestern Startup: NanoGraf

Founded: 2012 Northwestern Inventor: Harold Kung McCormick School of Engineering and Applied Science Department of Chemical and Biological Engineering Jiaxing Huang McCormick School of Engineering and Applied Science Department of Materials Science Formerly SiNode Systems, NanoGraf pursues advances in Lithium-ion battery anodes to transform a wide...

Published: 6/22/2026 | Updated: 5/5/2026 | Inventor(s):

Keywords(s): Batteries, Energy and Infrastructure, Fuel Cell, Graphene, Nanoparticle, Startup with Northwestern IP, Sustainability, Sustainable Materials

Category(s): Physical Sciences > Energy & Sustainability, Physical Sciences > Materials and Industrial Processes

Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets

SHORT DESCRIPTION A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets. INVENTORS Shana Kelley* Weinberg College of Arts & Sciences, Department of Chemistry Yi Li * Principal Investigator NU Tech ID: NU 2025-050 IP...

Published: 6/16/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, BIO2026, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools

Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy

NU 2025-160 INVENTORS Jason Miska* Feinberg School of Medicine, Department of Neurological Surgery Peng Zhang* Feinberg School of Medicine, Department of Neurological Surgery SHORT DESCRIPTION Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM. BACKGROUND Glioblastoma...

Published: 6/16/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): Adjunct therapy, BIO2026, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Nucleic Acids, RNA - Ribonucleic Acid, Therapeutics

Category(s): Life Sciences > Therapeutics

Bi-specific Lipid Nanoparticles for Boosting Antitumor Immunity in Glioblastoma

SHORT DESCRIPTION A bispecific lipid nanoparticle that bridges tumor-associated myeloid cells (TAMCs) and glioma cells by dual checkpoint blockade and simultaneously reprograms TAMCs into antitumor effectors via targeted delivery of a STING agonist. INVENTORS Maciej Lesniak* Northwestern University Feinberg School of Medicine,...

Published: 6/16/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): BIO2026, Brain cancer, Cancer/Oncology, Drug delivery, Immunotherapy, Nanoparticle, Nanotechnology, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

1 2 3 4 5 6 7