Search Results - small+molecule

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A Method for treating TNF-α-driven pathologies via Fn14 inhibition

https://wsu.technologypublisher.com/files/sites/ncs_3618.pdf

Published: 5/12/2026 | Updated: 5/12/2026 | Inventor(s): Salah-uddin Ahmed, Farheen Shaikh

Keywords(s): anti-inflammatory, Immunotherapy, small molecule, Therapeutics

Category(s): Technologies > Health & Well-being > Chemistry

Targeting Autoimmunity-Associated T cells via AHR Pathway Control

SHORT DESCRIPTION Use of AHR agonists to inhibit pathogenic Tfh/Tph cell differentiation, potentially reducing disease activity. INVENTORS Jaehyuk Choi* Northwestern University Feinberg School of Medicine, Department of Dermatology **(Now at UT Southwestern)** Deepak Rao Brigham and Women's...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Autoimmune disease, Immunology, Immunotherapy, Inflammation, RA - Rheumatoid arthritis, SLE - Systemic lupus erythematosus, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Incomplete Autophagy Induction for the Treatment of Cancer

SHORT DESCRIPTION This incomplete autophagy inducer triggers caspase-mediated apoptosis in cancer cells by inducing incomplete autophagy, leading to tumor reduction and improved survival. INVENTORS INVENTORS Maciej Lesniak* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery Jawad...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Brain cancer, Breast cancer, Cancer/Oncology, Lung cancer, Melanoma, Repurposed Drugs, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Once-Weekly Glucocorticoid Steroid Dosing for Enhanced Muscle Function and Metabolic Health

SHORT DESCRIPTION A glucocorticoid regimen that preserves the benefits of steroids on muscle mass and function while mitigating many of the metabolic and growth‑related toxicities seen with daily dosing in various inflammatory, autoimmune, respiratory, and neuromuscular disease settings. INVENTORS Elizabeth McNally*, MD, PhD Northwestern...

Published: 5/11/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Aging, DMD - Duchenne muscular dystrophy, Immunology, Inflammation, Metabolic disorders, Muscle metabolism, Rare diseases, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Interoceptomimetics: Dietary Supplements to Enhance Exercise Motivation and Performance

Enhancing exercise performance by modulating the activity of motivation-generating brain regions via stimulation of cannabinoid (CB1) receptors of the enteric nervous system. Problem: An increase in sedentary lifestyles driven by the modernization of society has led to a surge in several metabolic and neurological diseases worldwide. Although exercise...

Published: 4/30/2026 | Updated: 4/30/2026 | Inventor(s): Christoph Thaiss, John Nicholas Betley

Keywords(s): Aging, Cardiovascular, Healthcare IT, Microbiome, Neurology, Obesity Metabolic Disease and Diabetes, Regenerative Medicine, Small Molecule

Category(s): Technology Classifications > Food Science and Nutrition, Technology Classifications > Therapeutics

Dual-Action Inhibition Strategy for KRAS and LKB1 Mutant NSCLC

NU 2023-113 INVENTORS Lillian Eichner (Feinberg School of Medicine, Department of Biochemistry and Molecular Genetics)* Reuben Shaw (Salk Institute) SHORT DESCRIPTION A dual drug combination to target KRAS and LKB1 mutant non–small cell lung cancer that results in superior efficacy by enhancing T cell recruitment and reducing tumor burden. BACKGROUND Lung...

Published: 4/29/2026 | Updated: 4/29/2026 | Inventor(s): Reuben Shaw

Keywords(s): Cancer/Oncology, Lung cancer, Repurposed Drugs, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Inhibitors of MNK Kinase for Targeted Cancer and CNS Therapeutics.

NU 2015-098 (NU 2015-098, NU 2018-036, NU 2025-036) INVENTORS Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)* SHORT DESCRIPTION MNK kinase inhibitors that reduce cancer cell viability and proliferation and penetrates the brain for potential treatment of glioblastoma and CNS disorders. BACKGROUND Leukemia and brain...

Published: 5/6/2026 | Updated: 4/29/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, AML - Acute myeloid leukemia, ASD - Autism Spectrum Disorder, Bladder cancer, Brain cancer, Breast cancer, Cancer/Oncology, CNS - Central Nervous System, Colon cancer, Lung cancer, Neurodegenerative disease, Pancreatic cancer, Prostate cancer, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment

SHORT DESCRIPTION Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma. INVENTORS Amy Heimberger* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery * Principal Investigator NU Tech ID: NU 2025-212 IP...

Published: 5/7/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools

Selective PAD2 Inhibitors for Neuroprotection in Traumatic Brain Injury

SHORT DESCRIPTION Novel PAD2-selective inhibitor platform targeting neuroinflammation to support both acute neuroprotection and long-term functional recovery as a first-in-class treatment of traumatic brain injury. INVENTORS Hasan Alam* Northwestern University Feinberg School of Medicine, Department of Surgery (Trauma...

Published: 5/12/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): CNS - Central Nervous System, CVA - Cerebrovascular Accident, Neurodegenerative disease, Neuroinflammation, Neurologic disease, Neurology, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics

Category(s): Life Sciences > Therapeutics

Methods to Treat Neurodegenerative Disorders by Reducing Nuclear Aggregates and Modulating Adenosine‑to‑Inosine RNA Editing

SHORT DESCRIPTION Novel disease‑modifying approach that dissolves toxic nuclear RNA–protein aggregates and restores synaptic function in neurodegenerative diseases by inhibiting adenosine‑to‑inosine (A‑to‑I) RNA editing and modulating ADAR enzymes. INVENTORS Joseph Mazzulli* Northwestern University Feinberg School...

Published: 5/12/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): Lewy bodies, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, RNA - Ribonucleic Acid, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

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