Search Results - inflammation

59 Results

Sort By:

Targeting Autoimmunity-Associated T cells via AHR Pathway Control

SHORT DESCRIPTION Use of AHR agonists to inhibit pathogenic Tfh/Tph cell differentiation, potentially reducing disease activity. INVENTORS Jaehyuk Choi* Northwestern University Feinberg School of Medicine, Department of Dermatology **(Now at UT Southwestern)** Deepak Rao Brigham and Women's...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Autoimmune disease, Immunology, Immunotherapy, Inflammation, RA - Rheumatoid arthritis, SLE - Systemic lupus erythematosus, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Once-Weekly Glucocorticoid Steroid Dosing for Enhanced Muscle Function and Metabolic Health

SHORT DESCRIPTION A glucocorticoid regimen that preserves the benefits of steroids on muscle mass and function while mitigating many of the metabolic and growth‑related toxicities seen with daily dosing in various inflammatory, autoimmune, respiratory, and neuromuscular disease settings. INVENTORS Elizabeth McNally*, MD, PhD Northwestern...

Published: 5/11/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Aging, DMD - Duchenne muscular dystrophy, Immunology, Inflammation, Metabolic disorders, Muscle metabolism, Rare diseases, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Drug Repurposing for Age-Impaired Vascular Repair in COVID-19, Sepsis, and ARDS

SHORT DESCRIPTION Methods and compositions for treating COVID-19, sepsis, acute respiratory distress syndrome (ARDS), and cardiovascular diseases in elderly patients by either inhibiting vascular endothelial injury/inflammation or promoting FOXM1-dependent endothelial regeneration and vascular repair. INVENTORS Youyang Zhao Northwestern...

Published: 5/8/2026 | Updated: 4/22/2026 | Inventor(s):

Keywords(s): ARDS - Acute Respiratory Distress Syndrome, COVID-19, Immunology, Infectious disease, Inflammation, Pulmonary disease, Therapeutics, Vascular disease, Vascular repair

Category(s): Life Sciences > Therapeutics

Orthogonal Synthetic Receptors for IL-23

SHORT DESCRIPTION Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions. INVENTORS Joshua Leonard* McCormick School of Engineering, Department of Chemical and Biological Engineering Aaron Morris William Corcoran ...

Published: 5/8/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): Autoimmune disease, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools

Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares

SHORT DESCRIPTION An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares. INVENTORS Arthur Prindle* McCormick School of Engineering, Department of Chemical and Biological Engineering Jonathan...

Published: 5/11/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): Autoimmune disease, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics

Category(s): Life Sciences > Therapeutics

Recombinant Annexin Therapy for Muscle, Cardiac, and Neuronal Cell Membrane Repair

SHORT DESCRIPTION An annexin-based biological therapeutic that enhances the body's natural cell membrane repair process to reduce skeletal muscle, cardiac, and neuronal cell death and preserve tissue function. INVENTORS INVENTORS Elizabeth McNally* Feinberg School of Medicine, Department of Medicine (Cardiology Division) Alexis...

Published: 4/30/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): Biologic, Cardiomyopathy, DMD - Duchenne muscular dystrophy, Inflammation, Membrane injury and repair, Neurodegenerative disease, Rare diseases, SCI - Spinal cord injury, TBI - Traumatic brain injury, Therapeutics

Category(s): Life Sciences > Therapeutics

A Rat Model of IgA Nephropathy

NU 2019-196 INVENTORS Jing Jin* Xinfang Xie SHORT DESCRIPTION A novel rat model of IgA nephropathy (IgAN, also known as Berger's disease), enabling reproducible kidney mesangial deposits characteristic of the human disease for therapeutic and diagnostic evaluation. BACKGROUND IgAN, the most common glomerulonephritis worldwide, results...

Published: 4/13/2026 | Updated: 2/26/2026 | Inventor(s):

Keywords(s): Animal Model, Antibody, Drug screening, Immunology, Inflammation, Renal Disease, Research tool

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools

T Cells Targeting Misformed Proteins to Treat Neurodegenerative and Muscular Diseases

Antigen-specific immunotherapy with engineered cytotoxic T cells targeting misformed proteins to treat neurodegenerative and muscular diseases. Problem: Neurodegenerative and muscular diseases, such as amyotrophic lateral sclerosis (ALS), inclusion body myositis (IBM), and Alzheimer’s disease (AD), collectively affect over 5 million adults...

Published: 11/11/2025 | Updated: 10/30/2025 | Inventor(s): Ning Jenny Jiang, Shahab Chizari

Keywords(s): Bioengineering, Cell Therapy, Immunology, Immunotherapy, Inflammation, Neurodegenerative Diseases

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Gold Nanocluster-Based PROTAC Targeting pTau

Gold nanocluster binds both pTau and E3 ligase, initiating the ubiquitin-proteasome pathway and degrading pTau, as seen via immunostaining (Blue – Hoechst, red – TUJ1, green – pTau) Invention Summary: Hyperphosphorylated tau protein, a key clinical marker for various neurodegenerative diseases, leads to abnormal aggregation...

Published: 2/20/2026 | Updated: 9/12/2025 | Inventor(s): Sarah Nevins, Ki-Bum Lee

Keywords(s): Alzheimer’s, Drug Delivery, Inflammation, Nanoparticles

Category(s): Technology Classifications > Biomaterials, Technology Classifications > CNS Disorder, Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering

Intranasally-Delivered Therapy for Treatment of Amyotrophic Lateral Sclerosis

Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL). Problem: ALS a neurodegenerative disease with poor prognosis. ALS is categorized into the familial and sporadic types, with the former accounting...

Published: 9/30/2025 | Updated: 7/15/2025 | Inventor(s): Huafeng Wei

Keywords(s): Genetic Disorders, Inflammation, Neurodegenerative Diseases, Neurology, Pulmonary, Small Molecule

Category(s): Technology Classifications > Therapeutics

1 2 3 4 5 6