Search Results - inflammation

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Fecal Mitochondrial DNA as a Measure of Intestinal Inflammation

This technology introduces a novel method for detecting and assessing intestinal inflammation by measuring mitochondrial DNA levels in stool samples. Background: Intestinal inflammation is a critical indicator of various gastrointestinal disorders such as Inflammatory Bowel Disease (IBD), Environmental Enteropathic Dysfunction (EED), and Necrotizing...

Published: 6/29/2026 | Updated: 6/23/2026 | Inventor(s): Thomas Wallach

Keywords(s): anti-inflammatory therapeutic, DNA, inflammation, Technologies

Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Bioinformatics

Biomimetic HDL Nanoparticles for Treatment of Cancer, Immune and Inflammatory Disorders, and Cardiovascular Disease

SHORT DESCRIPTION Self-assembling biomimetic high-density lipoprotein nanoparticle (HDL NP) platform technology with a soft organic core, designed to more closely replicate key functional properties of mature human HDL for therapeutic use in cardiovascular disease, cancer, and inflammatory/immune disorders. INVENTORS Colby Thaxton* Northwestern...

Published: 6/16/2026 | Updated: 6/16/2026 | Inventor(s):

Keywords(s): Atherosclerosis, Autoimmune disease, BIO2026, Breast cancer, Cancer/Oncology, Cardiology and Cardiovascular disease, Gene therapy, Immunology, Immunotherapy, Inflammation, Nanomaterials, Nanoparticle, Nanotechnology, Nucleic Acids, Platform technology, Prostate cancer, Research tool, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics

Retargetable and Metabolically Tunable CAR Cell Platforms for Durable, Antigen‑Specific Cancer Therapy

SHORT DESCRIPTION A modular immunotherapy platform that combines hapten‑redirectable chimeric antigen receptor (CAR) constructs with itaconate‑programmed, memory‑like immune cells to deliver safer, more durable, and tunable antigen‑specific responses across hematologic and solid tumors. NU TECH ID NU 2023-021, NU 2024-077 INVENTORS Ashima...

Published: 6/10/2026 | Updated: 6/10/2026 | Inventor(s):

Keywords(s): Autoimmune disease, Cancer Treatment, Cancer/Oncology, Cell therapy, Immunology, Immunotherapy, Inflammation, Leukemia, Lymphoma, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Recombinant Annexin Therapy for Muscle, Cardiac, and Neuronal Cell Membrane Repair

SHORT DESCRIPTION An annexin-based biological therapeutic that enhances the body's natural cell membrane repair process to reduce skeletal muscle, cardiac, and neuronal cell death and preserve tissue function. INVENTORS INVENTORS Elizabeth McNally* Feinberg School of Medicine, Department of Medicine (Cardiology Division) Alexis...

Published: 6/16/2026 | Updated: 6/10/2026 | Inventor(s):

Keywords(s): BIO2026, Biologic, Cardiomyopathy, DMD - Duchenne muscular dystrophy, Inflammation, Membrane injury and repair, Neurodegenerative disease, Rare diseases, SCI - Spinal cord injury, TBI - Traumatic brain injury, Therapeutics

Category(s): Life Sciences > Therapeutics

Targeting Autoimmunity-Associated T cells via AHR Pathway Control

SHORT DESCRIPTION Use of AHR agonists to inhibit pathogenic Tfh/Tph cell differentiation, potentially reducing disease activity. INVENTORS Jaehyuk Choi* Northwestern University Feinberg School of Medicine, Department of Dermatology **(Now at UT Southwestern)** Deepak Rao Brigham and Women's...

Published: 6/16/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Autoimmune disease, BIO2026, Immunology, Immunotherapy, Inflammation, RA - Rheumatoid arthritis, SLE - Systemic lupus erythematosus, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Once-Weekly Glucocorticoid Steroid Dosing for Enhanced Muscle Function and Metabolic Health

SHORT DESCRIPTION A glucocorticoid regimen that preserves the benefits of steroids on muscle mass and function while mitigating many of the metabolic and growth‑related toxicities seen with daily dosing in various inflammatory, autoimmune, respiratory, and neuromuscular disease settings. INVENTORS Elizabeth McNally*, MD, PhD Northwestern...

Published: 6/16/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Aging, BIO2026, DMD - Duchenne muscular dystrophy, Immunology, Inflammation, Metabolic disorders, Muscle metabolism, Rare diseases, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Drug Repurposing for Age-Impaired Vascular Repair in COVID-19, Sepsis, and ARDS

SHORT DESCRIPTION Methods and compositions for treating COVID-19, sepsis, acute respiratory distress syndrome (ARDS), and cardiovascular diseases in elderly patients by either inhibiting vascular endothelial injury/inflammation or promoting FOXM1-dependent endothelial regeneration and vascular repair. INVENTORS Youyang Zhao Northwestern...

Published: 6/16/2026 | Updated: 4/22/2026 | Inventor(s):

Keywords(s): ARDS - Acute Respiratory Distress Syndrome, BIO2026, COVID-19, Immunology, Infectious disease, Inflammation, Pulmonary disease, Therapeutics, Vascular disease, Vascular repair

Category(s): Life Sciences > Therapeutics

Orthogonal Synthetic Receptors for IL-23

SHORT DESCRIPTION Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions. INVENTORS Joshua Leonard* McCormick School of Engineering, Department of Chemical and Biological Engineering Aaron Morris William Corcoran ...

Published: 6/16/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): Autoimmune disease, BIO2026, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools

Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares

SHORT DESCRIPTION An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares. INVENTORS Arthur Prindle* McCormick School of Engineering, Department of Chemical and Biological Engineering Jonathan...

Published: 6/16/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): Autoimmune disease, BIO2026, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics

Category(s): Life Sciences > Therapeutics

A Rat Model of IgA Nephropathy

NU 2019-196 INVENTORS Jing Jin* Xinfang Xie SHORT DESCRIPTION A novel rat model of IgA nephropathy (IgAN, also known as Berger's disease), enabling reproducible kidney mesangial deposits characteristic of the human disease for therapeutic and diagnostic evaluation. BACKGROUND IgAN, the most common glomerulonephritis worldwide, results...

Published: 4/13/2026 | Updated: 2/26/2026 | Inventor(s):

Keywords(s): Animal Model, Antibody, Drug screening, Immunology, Inflammation, Renal Disease, Research tool

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools

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