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Search Results - aging
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Once-Weekly Glucocorticoid Steroid Dosing for Enhanced Muscle Function and Metabolic Health
SHORT DESCRIPTION A glucocorticoid regimen that preserves the benefits of steroids on muscle mass and function while mitigating many of the metabolic and growth‑related toxicities seen with daily dosing in various inflammatory, autoimmune, respiratory, and neuromuscular disease settings. INVENTORS Elizabeth McNally*, MD, PhD Northwestern...
Published: 5/11/2026
|
Updated: 5/7/2026
|
Inventor(s):
Keywords(s):
Aging
,
DMD - Duchenne muscular dystrophy
,
Immunology
,
Inflammation
,
Metabolic disorders
,
Muscle metabolism
,
Rare diseases
,
Small molecule
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Interoceptomimetics: Dietary Supplements to Enhance Exercise Motivation and Performance
Enhancing exercise performance by modulating the activity of motivation-generating brain regions via stimulation of cannabinoid (CB1) receptors of the enteric nervous system. Problem: An increase in sedentary lifestyles driven by the modernization of society has led to a surge in several metabolic and neurological diseases worldwide. Although exercise...
Published: 4/30/2026
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Updated: 4/30/2026
|
Inventor(s):
Christoph Thaiss
,
John Nicholas Betley
Keywords(s):
Aging
,
Cardiovascular
,
Healthcare IT
,
Microbiome
,
Neurology
,
Obesity Metabolic Disease and Diabetes
,
Regenerative Medicine
,
Small Molecule
Category(s):
Technology Classifications > Food Science and Nutrition
,
Technology Classifications > Therapeutics
Pharmacological Treatment for Sleep Disorders Improving Sleep Quality & Architecture
Targeting Heat Shock Factor 1 (HSF1) via gene therapy or using pharmacological compounds targeting HSF1 (e.g. geranylgeranylacetone or macrocyclic peptides) can increase sleep stability, promote deeper sleep, reduce sleep fragmentation, and improve recovery from sleep loss. Problem: Millions of people worldwide suffer from disrupted sleep, whether due...
Published: 4/16/2026
|
Updated: 4/14/2026
|
Inventor(s):
Akhilesh Basi Reddy
,
Shintaro Yamazaki
Keywords(s):
Aging
,
Drug Target
,
Gene Therapy
,
Neurodegenerative Diseases
,
Protein/Peptide (Non-Antibody)
,
Small Molecule
,
Women's Health
Category(s):
Technology Classifications > Therapeutics
Machine Learning to Predict Physiological Age Using Features Extracted From Arterial Blood Pressure (ABP) Waveforms (Case No. 2025-264)
Summary: UCLA researchers in the Department of Anesthesiology have introduced a novel machine learning model that accurately predicts physiological
aging
by analyzing features extracted from patients’ arterial blood pressure (ABP) waveforms. This approach enables efficient, data-driven assessment of biological aging in clinical settings to facilitate...
Published: 12/5/2025
|
Updated: 10/23/2025
|
Inventor(s):
Maxime Cannesson
,
Ravi Pal
Keywords(s):
Aging
,
Anesthesiology
,
biomedical sensors
,
clinical care methodology
,
clinical decision support
,
clinical outcome
,
Clinical tool
,
Computer-Aided Diagnosis
,
consumer health products
,
Digital Health
,
digital health system
,
Fatigue (Medical)
,
Health and fitness
,
health risk assessment
,
Machine Learning
,
machine learning modeling
,
Medical Device
,
Medical diagnostics
,
Monitoring (Medicine)
,
personalized medicine
,
Preventive Medicine
,
public health monitoring
,
Smart medical device
,
Structural health monitoring
,
Telemedicine
Category(s):
Diagnostic Markers
,
Diagnostic Markers >
Aging
,
Life Science Research Tools
,
Medical Devices
Intranasally-Delivered Therapy For The Treatment Of Depression And Dementia
Intranasal nasal dantrolene nanoparticles alone, or in combination with lithium, can provide protection against depression and dementia with minimal or no side effects. Problem: Major depression disorder (MDD) affects 350 million patients in the world and about 16% of the population in USA. In addition, up to 50% of Alzheimer’s disease (AD)...
Published: 8/1/2025
|
Updated: 3/11/2025
|
Inventor(s):
Huafeng Wei
Keywords(s):
Aging
,
Immunology
,
Immunoncology
,
Infectious Disease
,
Inflammation
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Therapeutics
Intranasal Dantrolene Nanoparticle Use For Treatment Of Alzheimer's Disease
Intranasal delivering of dantrolene nanoparticles could potentially be used to inhibit memory loss and reduce amyloid plaques in patients with Alzheimer's disease. Problem: Alzheimer’s disease (AD) is a devastating neurodegenerative disease. The deficit in the development of new drugs targeting the amyloid pathology over the past several...
Published: 8/1/2025
|
Updated: 3/11/2025
|
Inventor(s):
Huafeng Wei
,
Qing Cheng Meng
,
Ge Liang
,
Maryellen Eckenhoff
Keywords(s):
Aging
,
COVID-19
,
Nanotechnology
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Animal Health
,
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Food Science and Nutrition
,
Technology Classifications > Research Tools & Reagents
,
Technology Classifications > Therapeutics
Machine-Learning Foundation Model For The Early Detection Of Neurodegenerative Diseases
A machine learning technique that identifies biomarkers from neuroim
aging
data, allowing for identification and treatment of populations vulnerable to neurodegenerative diseases. Problem: Neurodegenerative diseases such as Alzheimer’s disease (AD) impact an estimated twenty-four million people worldwide, with prevalence increasing with global...
Published: 5/11/2026
|
Updated: 1/17/2025
|
Inventor(s):
Saurabh Sihag
,
Alejandro Ribeiro
Keywords(s):
Aging
,
Artificial Intelligence (AI) & Machine Learning
,
Neurodegenerative Diseases
,
Neurology
,
Platform Technology
,
Radiology
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Digital Health
,
Technology Classifications > Im
aging
An Adaptive, Language-Agnostic, and Generalizable Method to Determine the Hearing Level and Speech Perception Abilities of a Patient
This hearing test is tuned to a patient’s hearing level and changes based on performance to accurately diagnose hearing ability Problem: Currently, no single hearing evaluation can determine multiple facets of an individual’s hearing ability. For example, some tests may determine hearing awareness at specific frequencies, but gather no data...
Published: 5/11/2026
|
Updated: 8/12/2024
|
Inventor(s):
Jason Brant
,
Tiffany Hwa
Keywords(s):
Aging
,
Neurodegenerative Diseases
,
Software
,
Surgery
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Testing & Measurement
Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)
UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....
Published: 7/17/2025
|
Updated: 2/26/2024
|
Inventor(s):
Mohammad Mahdi Hasani Sadrabadi
,
Song Li
,
Manish Butte
Keywords(s):
aAPCs
,
Aging
,
artificial presenting cells
,
cytokines
,
elderly
,
immunosenescence
,
microparticles
,
platform technology
,
SARS-CoV-2
,
T memory stem cells
,
TMSCs
,
Vaccines
Category(s):
Therapeutics > Infectious Diseases
,
Therapeutics > Oncology
In vitro Generation of an Autologous Thymic Organoid from Human Pluripotent Stem Cells
Abstract: The thymus is an integral part of the adaptive immune system as it generates T cells. Its function diminishes rapidly as the body ages, leading to a compromise of the immune system in the elderly. Reconstitution of adaptive immunity through mass production of different T cell types is therefore a therapeutic need in immunocompromised populations....
Published: 4/22/2025
|
Updated: 8/2/2023
|
Inventor(s):
Raul Sakoda
,
Nicholas Restifo
Keywords(s):
Aging
,
IMMUNOCOMPROMISED
,
Immunotherapy
,
Natural Killer T Cells
,
NKT
,
Organogenesis
,
Organoid
,
Pluripotent Stem Cells
,
T Cells
,
THYMUS
,
Vizcardo
Category(s):
Application > Therapeutics
,
TherapeuticArea > Oncology
,
TherapeuticArea > Immunology
,
Collaboration Sought > Licensing
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