Search Results - therapeutics

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MEK7 inhibitors for acute lymphoblastic leukemia (ALL) treatment

NU 2023-060 INVENTORS Karl Scheidt* Dalton Kim Meghan Orr SHORT DESCRIPTION Rational design of highly potent and selective covalent MEK7 inhibitors BACKGROUND Acute lymphoblastic leukemia (ALL) is a deadly blood cancer, the most common hematological malignancy in patients under 14 years of age. Despite advancements in treatment, ALL relapse...

Published: 8/10/2026 | Updated: 8/10/2026 | Inventor(s):

Keywords(s): ALL - Acute Lymphoblastic Leukemia, Cancer/Oncology, Leukemia, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Covalent MEK4 Inhibitors for Targeted Cancer Therapy

NU 2025-154 INVENTORS Karl Scheidt* Gina Connors SHORT DESCRIPTION This technology introduces novel covalent inhibitors of MEK4, built upon previously-developed reversible inhibitors (see NU2019-059 and NU2021-217). A covalent inhibition strategy offers enhanced potency, selectivity, and prolonged duration of action compared to reversible...

Published: 8/10/2026 | Updated: 8/10/2026 | Inventor(s):

Keywords(s): Cancer/Oncology, Covalent Inhibition, Kinase Inhibitor, Leukemia, MEK4, MEK7, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Improved MEK4 Inhibitors for the Treatment of Cancer

NU 2021-217 INVENTORS Karl Scheidt* Ada Jade Kwong Hidayatullah Munshi Thao Nguyen Pham SHORT DESCRIPTION This technology introduces novel indazole derivatives as potent and selective MEK4 inhibitors for cancer treatment, particularly in advanced prostate cancer and pancreatic adenocarcinoma. The lead molecule is optimized over first-generation...

Published: 8/10/2026 | Updated: 8/10/2026 | Inventor(s):

Keywords(s): Cancer/Oncology, Pancreatic cancer, Prostate cancer, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

CD40L-targeted therapies for myeloid diseases

NU 2016-012 INVENTORS Peng Ji* Kehan Ren Ermin Li SHORT DESCRIPTION Methods of targeting CD40L for treating TET2-mutant pre-malignant myeloid conditions BACKGROUND TET2 is one of the most frequently mutated genes in myeloid neoplasms and their precursor conditions, such as clonal hematopoiesis of indeterminate potential (CHIP), clonal cytopenia...

Published: 8/3/2026 | Updated: 8/3/2026 | Inventor(s):

Keywords(s): AML - Acute myeloid leukemia, Cancer Treatment, Cancer/Oncology, Immunotherapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Prevention and Treatment of Effects of Aging and Age-Associated Disorders with Ketone Supplementation

Advantages Reduces muscle atrophy and cachexia without requiring caloric restriction or fasting diets. Lowers inflammation and inflammatory markers, supporting faster recovery from infections and sepsis. Improves metabolic health by lowering blood glucose and balancing insulin and IGF1. Eases related complications, fights tumor growth, and blends...

Published: 7/27/2026 | Updated: 7/27/2026 | Inventor(s): Andrew Koutnik, Dominic D'Agostino

Keywords(s): Medical Therapeutics Cell Therapy, Therapeutics

Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical

Highly Miniaturized Closed-Loop Biosensing and Drug Delivery (Case No. 2025-276)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an implantable closed-loop system that integrates electrochemical biosensing, wireless signal transmission, and programmable drug release. Background: Conventional disease management systems rely on single-point measurements and discrete interval drug...

Published: 7/23/2026 | Updated: 7/23/2026 | Inventor(s): Aydin Babakhani, Iman Habibagahi, Hamid Jafarisharemi, Roshan Mathews

Keywords(s): biomedical implantation, biomedical sensors, Drug Delivery, Drug monitoring, Implant (Medicine), implantable sensors, Medical Device, minimally invasive drug delivery systems, on-demand drug delivery, personalized dose assessment, Smart medical device, Therapeutics, wearable, wearable electronics, wearable medical device, wearable medical devices, wearable sensors, wearable sensors for health, Wireless, wireless communication

Category(s): Life Science Research Tools, Electrical, Medical Devices, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery, Platforms

Small Molecule Inhibitors of the p38/MK2 Protein Interaction

Application New class of small molecule inhibitors with therapeutic potential for inflammatory diseases through disruption of the p38/MK2 protein-protein interaction. Key Benefits Therapeutic potential and utility for various inflammatory diseases. May have potentially fewer off-target effects and dose-limiting toxicities. May serve as a foundation...

Published: 7/21/2026 | Updated: 7/9/2026 | Inventor(s): Andrey Ivanov, Haian Fu

Keywords(s): Immunology and Inflammation Treatments, Neurology and Pain Treatments, Small Molecule, Therapeutics

Category(s): TechPub Algolia > Therapeutics

CD73-PROTACs for Cancer Therapy

SHORT DESCRIPTION A novel first-in-class proteolysis targeting chimera (PROTAC) that selectively degrades CD73 to reverse tumor immune evasion and inhibit cancer progression. INVENTORS Bin Zhang* Northwestern University Feinberg School of Medicine, Department of Medicine (Hematology & Oncology) Gary Schiltz* Weinberg...

Published: 7/6/2026 | Updated: 7/6/2026 | Inventor(s):

Keywords(s): BIO2026, Breast cancer, Cancer/Oncology, Colon cancer, Lung cancer, Melanoma, PROTAC, Targeted therapy, Therapeutics, TPD - Targeted protein degradation

Category(s): Life Sciences > Therapeutics

Polycomb Repressive Complex 1 (PRC1) Inhibitors to Restore Immune Response in B-Cell Lymphomas

SHORT DESCRIPTION A therapeutic approach that restores MHC-II expression using PRC1 inhibitors to reactivate anti-tumor immunity in B-cell lymphomas. INVENTORS Lu Wang* Zibo Zhao * Principal Investigator NU Tech ID: NU 2025-010 IP STATUS U.S. Provisional Patent Application has been filed. THERAPEUTICS...

Published: 6/25/2026 | Updated: 6/23/2026 | Inventor(s):

Keywords(s): Cancer/Oncology, Immunotherapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Compositions and Methods for Enhanced Mitochondrial Delivery for Regenerative Therapies

SHORT DESCRIPTION A novel peptide coating process that improves mitochondrial cell uptake, preserves function, and enables targeted delivery for cardiovascular and regenerative therapies. NU Tech ID NU 2025-055 INVENTORS Bin Jiang* Northwestern University Feinberg School of Medicine, Department of Surgery (Vascular...

Published: 6/18/2026 | Updated: 6/18/2026 | Inventor(s):

Keywords(s): BIO2026, Cardiology and Cardiovascular disease, MI - Myocardial Infarction, Neurodegenerative disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease, Vascular repair

Category(s): Life Sciences > Therapeutics

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