Search Results - drug+delivery

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Highly Efficient Approach for Developing Biocompatible and Potent Lipid Nanoparticles

Enhancing the biocompatibility and potency of lipid nanoparticles (LNPs) by refining the structure of ionizable lipids through an iterative method. Problem: Ionizable lipids play a crucial role in determining the potency and biocompatibility of LNPs. Current approaches, medicinal chemistry, and combinatorial chemistry, each have limitations. Medicinal...

Published: 5/8/2026 | Updated: 5/8/2026 | Inventor(s): Michael Mitchell, Xuexiang Han, Rohan Palanki

Keywords(s): Bioengineering, Drug Delivery, Nanotechnology, Platform Technology

Category(s): Technology Classifications > Therapeutics

Precise, Efficient Delivery of mRNA Medicine to the Placenta

Using tiny lipid nanoparticles (LNPs) to improve mRNA medicine delivery and uptake in the placenta for healthier pregnancies Problem: The placenta is an important biological barrier that connects the mother and fetus while keeping their blood supplies separate, enabling nutrient and oxygen delivery and waste removal for healthy development. Abnormal...

Published: 5/8/2026 | Updated: 5/8/2026 | Inventor(s): Michael Mitchell, Hannah Safford, Kelsey Swingle, Hannah Geisler

Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Immunotherapy, Women's Health

Category(s): Technology Classifications > Therapeutics

Targeted Nanocarriers for Brain Inflammation and Cancer Cachexia

Nanocarriers deliver anti-inflammatory therapeutics across the blood-brain barrier to activated microglia Background Delivering therapeutics to the brain remains a major drug-development challenge because the blood-brain barrier restricts systemic agents from reaching therapeutically relevant concentrations in the central nervous system. This barrier...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s): Oleh Taratula, Olena Taratula, Yoon Tae Goo

Keywords(s): anti-inflammatory, Anti-inflammatory drugs, biodegradable, biodistribution, blood-brain barrier, brain delivery, brain inflammation, CNS drug delivery, cytokine expression, Drug Delivery, Drug Development, glutathione, immune cell, immunohistochemistry, irak4 inhibitor, lipopolysaccharides, microglia, mouse model, nanocarrier, nanocarriers, nanomedicine, neuroinflammation, pancreatic cancer, pharmaceuticals, pharmacokinetics, preservation, pro-inflammatory cytokine, small molecules, water-soluble, weight maintenance

Category(s): Therapeutics

Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance

SHORT DESCRIPTION A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance. INVENTORS Edward Thorp* Northwestern University Feinberg School of Medicine, Department of Pathology Evan Scott* McCormick School of Engineering, Department...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation

Category(s): Life Sciences > Therapeutics

Northwestern Startup: Syenex, Inc.

Northwestern Inventor: Joshua Leonard McCormick School of Engineering Chemical and Biological Engineering Syenex builds bioengineering technologies to unlock the future of human health. Leveraging the power of synthetic biology, we design scalable, precision-engineered components, empowering cell and gene therapy developers to cure disease and build...

Published: 5/5/2026 | Updated: 5/5/2026 | Inventor(s):

Keywords(s): Biologic, Biomedical, Drug delivery, Gene therapy, Platform technology, Research tool, Startup with Northwestern IP, Synthetic biology, Therapeutics, Vector/Plasmid

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Therapeutics

STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment

SHORT DESCRIPTION Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma. INVENTORS Amy Heimberger* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery * Principal Investigator NU Tech ID: NU 2025-212 IP...

Published: 5/7/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools

Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets

SHORT DESCRIPTION A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets. INVENTORS Shana Kelley* Weinberg College of Arts & Sciences, Department of Chemistry Yi Li * Principal Investigator NU Tech ID: NU 2025-050 IP...

Published: 5/7/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools

Device For Rapid, Tunable, And Scalable Generation Of Lipid Nanoparticle Formulations

Microfluidic device for generation of large, precisely-defined, diverse lipid nanoparticle libraries for screening LNP formulations. Problem: Lipid nanoparticles (LNPs) have broad applications such as delivery agents for gene editing cargo, immunotherapies, and many clinical applications. The structures of the lipid components of an LNP, their relative...

Published: 4/17/2026 | Updated: 4/17/2026 | Inventor(s): Michael Mitchell, David Issadore, Andrew Hanna

Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Immunology, Immunotherapy, Microfluidics, Nanotechnology

Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Hardware & Components, Technology Classifications > Robotics

Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy

NU 2025-160 INVENTORS Jason Miska* Feinberg School of Medicine, Department of Neurological Surgery Peng Zhang* Feinberg School of Medicine, Department of Neurological Surgery SHORT DESCRIPTION Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM. BACKGROUND Glioblastoma...

Published: 4/16/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): Adjunct therapy, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Therapeutics

Category(s): Life Sciences > Therapeutics

Bi-specific Lipid Nanoparticles for Boosting Antitumor Immunity in Glioblastoma

SHORT DESCRIPTION A bispecific lipid nanoparticle that bridges tumor-associated myeloid cells (TAMCs) and glioma cells by dual checkpoint blockade and simultaneously reprograms TAMCs into antitumor effectors via targeted delivery of a STING agonist. INVENTORS Maciej Lesniak* Northwestern University Feinberg School of Medicine,...

Published: 4/30/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): Brain cancer, Cancer/Oncology, Drug delivery, Immunotherapy, Nanoparticle, Nanotechnology, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

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