Search Results - xuexiang+han

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Highly Efficient Approach for Developing Biocompatible and Potent Lipid Nanoparticles
Enhancing the biocompatibility and potency of lipid nanoparticles (LNPs) by refining the structure of ionizable lipids through an iterative method. Problem: Ionizable lipids play a crucial role in determining the potency and biocompatibility of LNPs. Current approaches, medicinal chemistry, and combinatorial chemistry, each have limitations. Medicinal...
Published: 5/8/2026   |   Updated: 5/8/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Rohan Palanki
Keywords(s): Bioengineering, Drug Delivery, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Rapid Synthesis of Amidine-Incorporated Degradable Lipids for Non-Liver mRNA delivery
One-pot combinatorial chemistry for fast and facile synthesis of amidine-incorporated degradable cationic lipids for lipid nanoparticle formulation and non-liver nucleic acid delivery. Problem: Messenger RNA (mRNA)-based therapeutics and vaccines have broad applications for a variety of diseases but require safe and efficient delivery mechanisms. Lipid...
Published: 2/10/2026   |   Updated: 2/10/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Junchao Xu
Keywords(s): Bioengineering, Drug Delivery, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms
Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems. Problem: CRISPR therapies can permanently correct disease-causing genes, but today's CRISPR delivery systems are either too risky or not potent enough. Viral vectors raise red flags...
Published: 1/14/2026   |   Updated: 1/14/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis
A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver. Problem: Lipid nanoparticles (LNPs) have been successfully used in FDA-approved therapies to deliver messenger RNA (mRNA) and small interfering RNA (siRNA) . One of the biggest challenge in developing...
Published: 12/8/2025   |   Updated: 5/12/2023   |   Inventor(s): Michael Mitchell, Xuexiang Han
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Platform Technology, Regenerative Medicine
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Double-Negative-Index Ceramic Aerogels For Thermal Superinsulation
Summary: UCLA researchers in the Departments of Chemistry and Biochemistry and Materials Science and Engineering have developed a novel ceramic aerogel material that has robust mechanical and thermal stability under extreme conditions. Background: Thermal insulation used in industries like aerospace and thermal power fields requires resistance to...
Published: 7/17/2025   |   Updated: 8/28/2019   |   Inventor(s): Xiangfeng Duan, Yu Huang, Xiang Xu
Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Structures
Category(s): Chemical > Industrial & Bulk Chemicals