Search Results - platform+technology

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Multipronged Composite Protocol for High-Efficiency Deep Tissue RNA Delivery and Expression
An RNA transfection and protein expression approach comprising lipid nanoparticles, hyaluronic acid, and photostimulation Problem: As the field of cell modification has expanded, researchers have sought more effective methods for nucleic acid (NA) delivery into cells. RNA transfection is easier to facilitate and control than DNA transfection, making...
Published: 5/13/2026   |   Updated: 5/13/2026   |   Inventor(s): James Eberwine, Jai-Yoon Sul, Hyunbum Kim
Keywords(s): Cell Therapy, Gene Editing, Gene Therapy, Platform Technology, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Highly Efficient Approach for Developing Biocompatible and Potent Lipid Nanoparticles
Enhancing the biocompatibility and potency of lipid nanoparticles (LNPs) by refining the structure of ionizable lipids through an iterative method. Problem: Ionizable lipids play a crucial role in determining the potency and biocompatibility of LNPs. Current approaches, medicinal chemistry, and combinatorial chemistry, each have limitations. Medicinal...
Published: 5/8/2026   |   Updated: 5/8/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Rohan Palanki
Keywords(s): Bioengineering, Drug Delivery, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Northwestern Startup: Syenex, Inc.
Northwestern Inventor: Joshua Leonard McCormick School of Engineering Chemical and Biological Engineering Syenex builds bioengineering technologies to unlock the future of human health. Leveraging the power of synthetic biology, we design scalable, precision-engineered components, empowering cell and gene therapy developers to cure disease and build...
Published: 5/5/2026   |   Updated: 5/5/2026   |   Inventor(s):  
Keywords(s): Biologic, Biomedical, Drug delivery, Gene therapy, Platform technology, Research tool, Startup with Northwestern IP, Synthetic biology, Therapeutics, Vector/Plasmid
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Therapeutics
Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets
SHORT DESCRIPTION A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets. INVENTORS Shana Kelley* Weinberg College of Arts & Sciences, Department of Chemistry Yi Li * Principal Investigator NU Tech ID: NU 2025-050 IP...
Published: 5/7/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
A Fast and Accurate Computational Method for Radiation Treatment Planning
A computational method for calculating the dose, Linear Energy Transfer and Relative Biological Effectiveness of proton treatment planning and optimization. Problem: In radiation therapy, the dose absorbed by cells determines their probability of survival. However, the biological effectiveness of the dose can vary. Multiple factors influence this variability,...
Published: 4/6/2026   |   Updated: 4/6/2026   |   Inventor(s): Alejandro Carabe Fernandez, Alejandro Bertolet Reina, Miguel Cortes Giraldo
Keywords(s): Oncology, Platform Technology, Radiology
Category(s): Technology Classifications > Testing & Measurement, Technology Classifications > Imaging, Technology Classifications > Medical Devices
A Precise and Effective Method of Proton Beam Therapy for Cancer Treatment
A method of proton beam therapy using a single energy proton beam delivered at multiple angles to the tumor. Problem: Proton therapy is a type of radiation treatment that uses high-energy protons to damage and kill cancer cells. To maximize therapeutic efficacy while limiting collateral damage to healthy cells, proton pencil beams are delivered from...
Published: 4/6/2026   |   Updated: 4/6/2026   |   Inventor(s): Alejandro Carabe Fernandez
Keywords(s): Oncology, Platform Technology, Radiology
Category(s): Technology Classifications > Imaging, Technology Classifications > Medical Devices
Reflective Polymer Coating For Microscale Electronic Communication
A polymer coating which allows a device’s electrical activity to be optically transmitted based on its transparency. Problem: Existing wireless microscale communication platforms, such as radio-frequency antennas and micro-LEDs, are limited in their large footprint requirements relative to the chip size, have challenging integration pathways...
Published: 3/16/2026   |   Updated: 3/16/2026   |   Inventor(s): Marc Miskin, Matthew Campbell
Keywords(s): Electronic Materials, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Hardware & Components, Technology Classifications > Materials
Rapid Synthesis of Amidine-Incorporated Degradable Lipids for Non-Liver mRNA delivery
One-pot combinatorial chemistry for fast and facile synthesis of amidine-incorporated degradable cationic lipids for lipid nanoparticle formulation and non-liver nucleic acid delivery. Problem: Messenger RNA (mRNA)-based therapeutics and vaccines have broad applications for a variety of diseases but require safe and efficient delivery mechanisms. Lipid...
Published: 2/10/2026   |   Updated: 2/10/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Junchao Xu
Keywords(s): Bioengineering, Drug Delivery, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Mechanically Tunable Engineered Heart Tissue Platform
Next-generation engineered heart tissue platform that enables precise tuning of mechanical properties of microenvironment to study the structure, development, and function of cultured cells or human-derived cardiac tissues. Problem: Engineering heart tissue (EHT) platforms have the potential to study heart physiology, disease pathology, and therapeutic...
Published: 1/30/2026   |   Updated: 1/30/2026   |   Inventor(s): Kenneth Margulies, Benjamin Lee, Nesrine Bouhrira
Keywords(s): Bioengineering, Cardiovascular, Drug Target, Platform Technology
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
A Method for One-Step, Aqueous Phase Generation of Ultrasmall Inorganic Nanoparticles for Biomedical Applications.
A method to generate homogenous and stable inorganic nanoparticles (NPs) using a microfluidic device with two jet inlets. Problem: Inorganic nanoparticles have promise as contrast agents and therapeutics due to their high renal clearance and therefore low toxicity. However, they are limited by factors including complex synthesis routes with unfavorable...
Published: 1/21/2026   |   Updated: 1/20/2026   |   Inventor(s): David Cormode, Hyun (Michel) Koo, Nil Kanatha Pandey, Andrea Kian, Portia Maidment, Derick Rosario Berrios
Keywords(s): Microfluidics, Platform Technology, Radiology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
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