Search Results - neurodegenerative+diseases

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An Implantable Device for Restoring Muscle Function in Nerve or Muscle Impairment
A neuroprosthetic implant that uses existing nerve or muscle signals to replace damaged muscle and restores movement Problem: While prosthetics often replace entire limbs, smaller nerve or muscle injuries are common, severely impact daily life, and have limited treatment options. Facial paralysis is one example, where nerve damage causes muscle weakness,...
Published: 6/26/2026   |   Updated: 6/25/2026   |   Inventor(s): Niv Milbar, Cynthia Sung, Flavia Vitale, Gabriel Unger, Raghav Garg
Keywords(s): Bioengineering, Neurodegenerative Diseases, Neurology, Surgery
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Robotics
Ultrafast, Sensitive, And Long-Lasting Bioelectrochemical Transistors
Supramolecular crown ethers and fluorinated polymers enable the formation of high ionic conductivity, water-impermeable artificial ion channels for bioelectronic transistor applications. Problem: Organic electrochemical transistors (OECTs) are central to bioelectronics by enabling sensitive amplification of weak biological signals through ionic-electronic...
Published: 5/28/2026   |   Updated: 5/28/2026   |   Inventor(s): Yuanwen Jiang, Yuhui Wang
Keywords(s): Bioengineering, Electronic Materials, Nanotechnology, Neurodegenerative Diseases, Neurology, Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Hardware & Components, Technology Classifications > Materials, Technology Classifications > Medical Devices
An All-In-One “Swiss Army Knife” Tool To Edit Genes And Regulate Their Expression Without Off-Target Effects And Toxicity
A flexible toolkit for human gene editing, activation, and repression that can be applied in orthogonally and in various disease models. Problem: There is increasing demand for technologies that can simultaneously edit the genome and regulate the transcriptome without relying on toxic double-stranded breaks. Currently, treating complex diseases such...
Published: 6/26/2026   |   Updated: 5/5/2026   |   Inventor(s): Xue Sherry Gao, Tyler Daniel, Hongzhi Zeng, Qichen Yuan
Keywords(s): Bioengineering, Cell Therapy, Gene Editing, Genetic Disorders, Neurodegenerative Diseases, Obesity Metabolic Disease and Diabetes, Oncology, Orphan Disease, Pulmonary
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Pharmacological Treatment for Sleep Disorders Improving Sleep Quality & Architecture
Targeting Heat Shock Factor 1 (HSF1) via gene therapy or using pharmacological compounds targeting HSF1 (e.g. geranylgeranylacetone or macrocyclic peptides) can increase sleep stability, promote deeper sleep, reduce sleep fragmentation, and improve recovery from sleep loss. Problem: Millions of people worldwide suffer from disrupted sleep, whether due...
Published: 4/16/2026   |   Updated: 4/14/2026   |   Inventor(s): Akhilesh Basi Reddy, Shintaro Yamazaki
Keywords(s): Aging, Drug Target, Gene Therapy, Neurodegenerative Diseases, Protein/Peptide (Non-Antibody), Small Molecule, Women's Health
Category(s): Technology Classifications > Therapeutics
An Accessible and Automated Device to Diagnose Nerve and Muscle Disorders
A device consisting of electrode patches, a control box, and software for automated nerve conduction studies. Problem: Nerve conduction studies are essential tools in the diagnosis and management of nerve and muscle disorders. However, current diagnostic tools rely heavily on trained physicians, manual testing protocols, and the precise placement of...
Published: 6/30/2026   |   Updated: 4/8/2026   |   Inventor(s): Josh Baxter, Flavia Vitale, Margaret (Maggie) Wagner, Quinn Tate
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Bioengineering, Neurodegenerative Diseases, Neurology, Orthopedics, Software
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Testing & Measurement
T Cells Targeting Misformed Proteins to Treat Neurodegenerative and Muscular Diseases
Antigen-specific immunotherapy with engineered cytotoxic T cells targeting misformed proteins to treat neurodegenerative and muscular diseases. Problem: Neurodegenerative and muscular diseases, such as amyotrophic lateral sclerosis (ALS), inclusion body myositis (IBM), and Alzheimer’s disease (AD), collectively affect over 5 million adults...
Published: 11/11/2025   |   Updated: 10/30/2025   |   Inventor(s): Ning Jenny Jiang, Shahab Chizari
Keywords(s): Bioengineering, Cell Therapy, Immunology, Immunotherapy, Inflammation, Neurodegenerative Diseases
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Fenchol: A Natural Therapeutic for Cognitive Health and Neurodegenerative Care
Advantages Targeting neuroinflammation and proteostasis Strong preclinical efficacy in cells, C. elegans, and Alzheimer’s mouse models GRAS-designated natural compound with excellent safety profile Multiple delivery formats: oral, nasal, buccal, topical, supplement Summary Neurodegenerative diseases such as Alzheimer’s Disease (AD)...
Published: 6/22/2026   |   Updated: 7/11/2025   |   Inventor(s): Hariom Yadav, Shalini Jain, Sidharth Mishra
Keywords(s): Neurodegenerative Diseases, Neuroscience, Nutrition / Diet Health
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
Cardiac Dysfunction in Friedreich’s Ataxia: Remodelling of the Cardiac Calcium Handling Machinery
Advantages: This study discovered a potential novel mechanism of cardiac dysfunction in Friedreich's ataxia (FA) by uncovering dysregulation in key calcium-handling proteins and mitochondrial dysfunction The study correlates data from an FA mouse model (FXN-KO) with human clinical manifestations, linking frataxin deficiency to cardiac dysfunction...
Published: 6/22/2026   |   Updated: 7/11/2025   |   Inventor(s): Bojjibabu Chidipi
Keywords(s): Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience
Gamified Physical Therapy Rehabilitation System
Advantages: Turns muscle movement into gameplay using wearable EMG sensors Personalizes difficulty based on each user’s strength and ability Keeps patients engaged and motivated with real-time feedback and rewards Designed for at-home or clinical use, with easy setup and data tracking Summary: Physical therapy with a licensed physical...
Published: 6/22/2026   |   Updated: 6/6/2025   |   Inventor(s): John Templeton, Gabriel Mozombite Gallegos, Ashley Pham, Nathan Schilaty, Antonio Gonzalez, Voon Hee Lee
Keywords(s): Devices for Disabilities / Rehabilitation, Digital Healthcare, Human Computer Interfaces, Medical Devices, Neurodegenerative Diseases, Simulation Training Aid, Wearable Electronics
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Medical Devices
Binding Between TREM2 and Heparan Sulfate Delineates the Role of Microglia in AD and Reveals Novel Treatment Strategies
Advantages: Discovered novel structural interactions between HS and TREM2, associated with neurodegeneration High-affinity binding: TREM2 specifically interacts with Heparan Sulfate (HS) modified with 6-O-sulfation and iduronic acid, enabling precise microglial modulation compared to broad-spectrum anti-inflammatory strategies Defined structural...
Published: 6/22/2026   |   Updated: 4/25/2025   |   Inventor(s): Lianchun Wang, Ilayda McMillan
Keywords(s): Immunology, Neurodegenerative Diseases, Neuroscience
Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
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