Search Results - oncology

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clampFISH 2.0: Fast, Cost-Effective RNA Detection Using Potent Fluorescent Probes
Molecular diagnostic using clamping fluorescent probes to amplify RNA detection signal of single-cell assay Problem: The molecular diagnostics market is expected to reach $13 billion by 2024, including cancer detection, blood screening, histology assays, tests for transplant compatibility, and inherited and infectious diseases (The World Market for...
Published: 6/29/2026   |   Updated: 6/26/2026   |   Inventor(s): Arjun Raj, Ian Dardani, Benjamin Emert, Sara Rouhanifard
Keywords(s): Bioengineering, Infectious Disease, Nanotechnology, Oncology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Diagnostics
A Fast And Cost-Effective Method For Early Cancer Detection
A quick and inexpensive method to detect cancer early by exponentially amplifying rare and scarce cancer mutations. Problem: Early cancer detection is challenging due to the low levels of cancer-indicating mutant DNA compared to healthy, wild-type DNA. The background noise from the substantial amounts of healthy DNA overwhelms mutant signals. Some...
Published: 6/12/2026   |   Updated: 6/12/2026   |   Inventor(s): Haim Bau, Jinzhao Song, Junman Chen
Keywords(s): Bioengineering, Gene Editing, Gene Therapy, Oncology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents
Increasing Efficiency of Anti-Tumor Immune Checkpoint Blockade Therapy by Manipulating Tumor-Associated Macrophages
A method to manipulate tumor-associated macrophages by targeting the mitochondrial electron transport chain, improving the efficacy of immune checkpoint blockade cancer therapies. Problem: Many cancer therapeutics work by activating the immune system to attack a tumor. These drugs, known as immune checkpoint blockade (ICB) therapies, commonly fail because...
Published: 5/13/2026   |   Updated: 5/13/2026   |   Inventor(s): Jorge Henao-Mejia, Megan Clark
Keywords(s): Drug Target, Immunology, Oncology
Category(s): Technology Classifications > Therapeutics
An All-In-One “Swiss Army Knife” Tool To Edit Genes And Regulate Their Expression Without Off-Target Effects And Toxicity
A flexible toolkit for human gene editing, activation, and repression that can be applied in orthogonally and in various disease models. Problem: There is increasing demand for technologies that can simultaneously edit the genome and regulate the transcriptome without relying on toxic double-stranded breaks. Currently, treating complex diseases such...
Published: 6/26/2026   |   Updated: 5/5/2026   |   Inventor(s): Xue Sherry Gao, Tyler Daniel, Hongzhi Zeng, Qichen Yuan
Keywords(s): Bioengineering, Cell Therapy, Gene Editing, Genetic Disorders, Neurodegenerative Diseases, Obesity Metabolic Disease and Diabetes, Oncology, Orphan Disease, Pulmonary
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Benzofuranoindoline-Containing Fungal RiPP-Derived Anticancer Compounds
Benzofuranoindoline-containing fungal RiPP-derived compounds and analogs, plus pharmaceutical compositions, and administration methods for treating cancers, including leukemia. Problem: The disclosure targets diseases and disorders where new therapeutic compounds are needed, including cancers such as leukemia. Fungal ribosomally synthesized and post-translationally...
Published: 4/16/2026   |   Updated: 4/16/2026   |   Inventor(s): Xue Sherry Gao, Hans Renata, Qiuyue Nie
Keywords(s): Oncology, Small Molecule
Category(s): Technology Classifications > Therapeutics
A Fast and Accurate Computational Method for Radiation Treatment Planning
A computational method for calculating the dose, Linear Energy Transfer and Relative Biological Effectiveness of proton treatment planning and optimization. Problem: In radiation therapy, the dose absorbed by cells determines their probability of survival. However, the biological effectiveness of the dose can vary. Multiple factors influence this variability,...
Published: 4/6/2026   |   Updated: 4/6/2026   |   Inventor(s): Alejandro Carabe Fernandez, Alejandro Bertolet Reina, Miguel Cortes Giraldo
Keywords(s): Oncology, Platform Technology, Radiology
Category(s): Technology Classifications > Testing & Measurement, Technology Classifications > Imaging, Technology Classifications > Medical Devices
A Precise and Effective Method of Proton Beam Therapy for Cancer Treatment
A method of proton beam therapy using a single energy proton beam delivered at multiple angles to the tumor. Problem: Proton therapy is a type of radiation treatment that uses high-energy protons to damage and kill cancer cells. To maximize therapeutic efficacy while limiting collateral damage to healthy cells, proton pencil beams are delivered from...
Published: 4/6/2026   |   Updated: 4/6/2026   |   Inventor(s): Alejandro Carabe Fernandez
Keywords(s): Oncology, Platform Technology, Radiology
Category(s): Technology Classifications > Imaging, Technology Classifications > Medical Devices
Instant, Calibration-Free Blood-Flow Measurement With A Single Optical Snapshot
A single-frame, multi-exposure time optical method enabling accurate extraction of absolute speckle decorrelation time and optimized for recovery of absolute deep-tissue blood flow. Problem: Accurately recovering absolute speckle decorrelation time without the use of calibration or complex instrumentation is challenging. For the use case of monitoring...
Published: 1/8/2026   |   Updated: 1/8/2026   |   Inventor(s): Arjun Yodh, Wesley Baker, Joseph Majeski, Rodrigo Menezes Forti
Keywords(s): Bioengineering, Cardiovascular, Electronic Materials, Gastroenterology, Internet of Things, Nephrology and Urology, Neurology, Oncology, Ophthalmology, Optics & Photonics , Platform Technology, Surgery
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Diagnostics, Technology Classifications > Digital Health, Technology Classifications > Hardware & Components, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents, Technology Classifications > Medical Devices, Technology Classifications > Testing & Measurement
Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47
A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis. Problem: Phagocytosis of ‘self’ cells is generally inhibited by a key macrophage checkpoint interaction between SIRPα on the macrophage and...
Published: 12/15/2025   |   Updated: 12/15/2025   |   Inventor(s): Dennis Discher, Jason Andrechak, Lawrence Dooling
Keywords(s): Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Novel AKR1C3 Inhibitors in Cancer
Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent malignancies of the prostate, breast and endometrium Value Proposition: Standard treatment of care for hormone-dependent tumors utilizes hormone ablative therapies. These agents non-discriminately block the action of estrogens and androgens and have untoward side...
Published: 10/30/2025   |   Updated: 10/30/2025   |   Inventor(s): Trevor Penning, Adegoke Adeniji, Michael Byrns, Jeffrey Winkler, Barry Twenter, Lawrence Marnett, Andy Liedtke
Keywords(s): Men's Health, Oncology, Small Molecule, Women's Health
Category(s): Technology Classifications > Therapeutics
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