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Search Results - gene+therapy
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Lipid nanoparticles for lung-targeted mRNA delivery
This technology is a new lipid nanoparticle system that can safely, specifically, and efficiently deliver mRNA to a patient’s lungs. Background: Therapeutics that deliver mRNA to a patient’s lungs offer significant potential for treating a broad spectrum of lung diseases. However, specifically and efficiently delivering mRNA to lung tissue...
Published: 6/22/2026
|
Updated: 6/21/2026
|
Inventor(s):
Yamin Li
,
David Popoola
,
Zhi Cao
,
Yuqin Men
Keywords(s):
biomaterials
,
chemistry
,
drug delivery
,
gene therapy
,
nanoparticle drug delivery
,
RNA
,
Technologies
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Therapeutics and Vaccines
Durable cure for Pseudoxanthoma Elasticum: High-Efficiency, Precision-Targeted
Gene Therapy
Lipid nanoparticles containing messenger RNA (mRNA-LNPs) encoding Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) base-editors that correct pseudoxanthoma elasticum-causing mutations. Problem: Pseudoxanthoma elasticum (PXE) is a genetic disorder affecting approximately 1 in 25,000 Americans. It is caused by loss-of-function mutations...
Published: 6/17/2026
|
Updated: 6/17/2026
|
Inventor(s):
Xiao Wang
,
Hanbing Cao
Keywords(s):
Bioengineering
,
Cardiovascular
,
Gene Editing
,
Gene Therapy
,
Genetic Disorders
,
Orphan Disease
Category(s):
Technology Classifications > Research Tools & Reagents
,
Technology Classifications > Therapeutics
Biomimetic HDL Nanoparticles for Treatment of Cancer, Immune and Inflammatory Disorders, and Cardiovascular Disease
SHORT DESCRIPTION Self-assembling biomimetic high-density lipoprotein nanoparticle (HDL NP) platform technology with a soft organic core, designed to more closely replicate key functional properties of mature human HDL for therapeutic use in cardiovascular disease, cancer, and inflammatory/immune disorders. INVENTORS Colby Thaxton* Northwestern...
Published: 6/16/2026
|
Updated: 6/16/2026
|
Inventor(s):
Keywords(s):
Atherosclerosis
,
Autoimmune disease
,
BIO2026
,
Breast cancer
,
Cancer/Oncology
,
Cardiology and Cardiovascular disease
,
Gene therapy
,
Immunology
,
Immunotherapy
,
Inflammation
,
Nanomaterials
,
Nanoparticle
,
Nanotechnology
,
Nucleic Acids
,
Platform technology
,
Prostate cancer
,
Research tool
,
Small molecule
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Biomarkers & Biomedical Research Tools
,
Life Sciences > Healthcare Devices, Tools & IT
,
Life Sciences > Therapeutics
A Fast And Cost-Effective Method For Early Cancer Detection
A quick and inexpensive method to detect cancer early by exponentially amplifying rare and scarce cancer mutations. Problem: Early cancer detection is challenging due to the low levels of cancer-indicating mutant DNA compared to healthy, wild-type DNA. The background noise from the substantial amounts of healthy DNA overwhelms mutant signals. Some...
Published: 6/12/2026
|
Updated: 6/12/2026
|
Inventor(s):
Haim Bau
,
Jinzhao Song
,
Junman Chen
Keywords(s):
Bioengineering
,
Gene Editing
,
Gene Therapy
,
Oncology
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Research Tools & Reagents
Gene Editing of Monogenic Disorders in Human Hematopoietic Stem Cells
Case 2018-372Researchers at the UCLA Department of Microbiology, Immunology & Molecular Genetics have developed novel methods to achieve efficient, precise gene integration and effective expression of cDNA cassettes to express normal versions of genes in hematopoietic stem cells.BACKGROUNDHematopoietic stem cells (HSCs) have great therapeutic potential...
Published: 6/3/2026
|
Updated: 6/3/2026
|
Inventor(s):
Donald Kohn
,
Caroline Kuo
,
Zulema Romero Garcia
,
Roger Hollis
Keywords(s):
Drug Delivery
,
Gene Editing Systems
,
Gene Therapy
,
Life Science Research Tools
Category(s):
Platforms > Drug Delivery
,
Therapeutics >
Gene Therapy
And Editing
,
Life Science Research Tools
Epigenetic Gene Editing in Cardiomyopathy to Improve Heart Function
SHORT DESCRIPTION A precision cardiac gene‑regulation platform that deletes a MYH7 enhancer to shift ventricular myosin isoform balance toward faster α‑MHC and activates upstream MYH6 enhancers to increase MYH6 expression and improve contractility, creating a dual toolkit for disease‑modifying therapy in cardiomyopathy and heart failure. INVENTORS Elizabeth...
Published: 6/16/2026
|
Updated: 5/12/2026
|
Inventor(s):
Keywords(s):
BIO2026
,
Cardiology and Cardiovascular disease
,
Cardiomyopathy
,
Gene therapy
,
Regenerative medicine
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Precise, Efficient Delivery of mRNA Medicine to the Placenta
Using tiny lipid nanoparticles (LNPs) to improve mRNA medicine delivery and uptake in the placenta for healthier pregnancies Problem: The placenta is an important biological barrier that connects the mother and fetus while keeping their blood supplies separate, enabling nutrient and oxygen delivery and waste removal for healthy development. Abnormal...
Published: 5/8/2026
|
Updated: 5/8/2026
|
Inventor(s):
Michael Mitchell
,
Hannah Safford
,
Kelsey Swingle
,
Hannah Geisler
Keywords(s):
Bioengineering
,
Drug Delivery
,
Gene Therapy
,
Immunology
,
Immunotherapy
,
Women's Health
Category(s):
Technology Classifications > Therapeutics
Northwestern Startup: Syenex, Inc.
Northwestern Inventor: Joshua Leonard McCormick School of Engineering Chemical and Biological Engineering Syenex builds bioengineering technologies to unlock the future of human health. Leveraging the power of synthetic biology, we design scalable, precision-engineered components, empowering cell and
gene therapy
developers to cure disease and build...
Published: 6/22/2026
|
Updated: 5/5/2026
|
Inventor(s):
Keywords(s):
Biologic
,
Biomedical
,
Drug delivery
,
Gene therapy
,
Platform technology
,
Research tool
,
Startup with Northwestern IP
,
Synthetic biology
,
Therapeutics
,
Vector/Plasmid
Category(s):
Life Sciences > Biomarkers & Biomedical Research Tools
,
Life Sciences > Therapeutics
Precision
Gene Therapy
for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision
gene therapy
targeting endothelial dysfunction in specific organs. INVENTORS Youyang Zhao* Ann & Robert H Lurie Children's Hospital of Chicago * Principal Investigator NU...
Published: 6/16/2026
|
Updated: 4/27/2026
|
Inventor(s):
Keywords(s):
BIO2026
,
Cardiology and Cardiovascular disease
,
CMD - Cardiometabolic disease
,
CPD - Cardiopulmonary disease
,
Gene therapy
,
Pulmonary disease
,
Regenerative medicine
,
Targeted therapy
,
Therapeutics
,
Vascular disease
Category(s):
Life Sciences > Therapeutics
Device For Rapid, Tunable, And Scalable Generation Of Lipid Nanoparticle Formulations
Microfluidic device for generation of large, precisely-defined, diverse lipid nanoparticle libraries for screening LNP formulations. Problem: Lipid nanoparticles (LNPs) have broad applications such as delivery agents for gene editing cargo, immunotherapies, and many clinical applications. The structures of the lipid components of an LNP, their relative...
Published: 4/17/2026
|
Updated: 4/17/2026
|
Inventor(s):
Michael Mitchell
,
David Issadore
,
Andrew Hanna
Keywords(s):
Bioengineering
,
Drug Delivery
,
Gene Editing
,
Gene Therapy
,
Immunology
,
Immunotherapy
,
Microfluidics
,
Nanotechnology
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Hardware & Components
,
Technology Classifications > Robotics
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