Search Results - gene+therapy

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Multipronged Composite Protocol for High-Efficiency Deep Tissue RNA Delivery and Expression

An RNA transfection and protein expression approach comprising lipid nanoparticles, hyaluronic acid, and photostimulation Problem: As the field of cell modification has expanded, researchers have sought more effective methods for nucleic acid (NA) delivery into cells. RNA transfection is easier to facilitate and control than DNA transfection, making...

Published: 5/13/2026 | Updated: 5/13/2026 | Inventor(s): James Eberwine, Jai-Yoon Sul, Hyunbum Kim

Keywords(s): Cell Therapy, Gene Editing, Gene Therapy, Platform Technology, Protein/Peptide (Non-Antibody)

Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics

Epigenetic Gene Editing in Cardiomyopathy to Improve Heart Function

SHORT DESCRIPTION A precision cardiac gene‑regulation platform that deletes a MYH7 enhancer to shift ventricular myosin isoform balance toward faster α‑MHC and activates upstream MYH6 enhancers to increase MYH6 expression and improve contractility, creating a dual toolkit for disease‑modifying therapy in cardiomyopathy and heart failure. INVENTORS Elizabeth...

Published: 5/13/2026 | Updated: 5/12/2026 | Inventor(s):

Keywords(s): Cardiology and Cardiovascular disease, Cardiomyopathy, Gene therapy, Regenerative medicine, Therapeutics

Category(s): Life Sciences > Therapeutics

Precise, Efficient Delivery of mRNA Medicine to the Placenta

Using tiny lipid nanoparticles (LNPs) to improve mRNA medicine delivery and uptake in the placenta for healthier pregnancies Problem: The placenta is an important biological barrier that connects the mother and fetus while keeping their blood supplies separate, enabling nutrient and oxygen delivery and waste removal for healthy development. Abnormal...

Published: 5/8/2026 | Updated: 5/8/2026 | Inventor(s): Michael Mitchell, Hannah Safford, Kelsey Swingle, Hannah Geisler

Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Immunotherapy, Women's Health

Category(s): Technology Classifications > Therapeutics

Northwestern Startup: Syenex, Inc.

Northwestern Inventor: Joshua Leonard McCormick School of Engineering Chemical and Biological Engineering Syenex builds bioengineering technologies to unlock the future of human health. Leveraging the power of synthetic biology, we design scalable, precision-engineered components, empowering cell and gene therapy developers to cure disease and build...

Published: 5/5/2026 | Updated: 5/5/2026 | Inventor(s):

Keywords(s): Biologic, Biomedical, Drug delivery, Gene therapy, Platform technology, Research tool, Startup with Northwestern IP, Synthetic biology, Therapeutics, Vector/Plasmid

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Therapeutics

Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction

SHORT DESCRIPTION Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs. INVENTORS Youyang Zhao* Ann & Robert H Lurie Children's Hospital of Chicago * Principal Investigator NU...

Published: 5/8/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease

Category(s): Life Sciences > Therapeutics

Device For Rapid, Tunable, And Scalable Generation Of Lipid Nanoparticle Formulations

Microfluidic device for generation of large, precisely-defined, diverse lipid nanoparticle libraries for screening LNP formulations. Problem: Lipid nanoparticles (LNPs) have broad applications such as delivery agents for gene editing cargo, immunotherapies, and many clinical applications. The structures of the lipid components of an LNP, their relative...

Published: 4/17/2026 | Updated: 4/17/2026 | Inventor(s): Michael Mitchell, David Issadore, Andrew Hanna

Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Immunology, Immunotherapy, Microfluidics, Nanotechnology

Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Hardware & Components, Technology Classifications > Robotics

Pharmacological Treatment for Sleep Disorders Improving Sleep Quality & Architecture

Targeting Heat Shock Factor 1 (HSF1) via gene therapy or using pharmacological compounds targeting HSF1 (e.g. geranylgeranylacetone or macrocyclic peptides) can increase sleep stability, promote deeper sleep, reduce sleep fragmentation, and improve recovery from sleep loss. Problem: Millions of people worldwide suffer from disrupted sleep, whether due...

Published: 4/16/2026 | Updated: 4/14/2026 | Inventor(s): Akhilesh Basi Reddy, Shintaro Yamazaki

Keywords(s): Aging, Drug Target, Gene Therapy, Neurodegenerative Diseases, Protein/Peptide (Non-Antibody), Small Molecule, Women's Health

Category(s): Technology Classifications > Therapeutics

Noninvasive brain-specific inhibition of bone morphogenetic protein signaling for the prevention of tauopathy

NU2025-330 INVENTORS John Kessler* Justin Geier Chian-Yu Peng SHORT DESCRIPTION This invention uses a noninvasive gene therapy approach to prevent and treat tauopathies, such as Alzheimer's disease and frontotemporal dementia, by inhibiting bone morphogenetic protein (BMP) specifically within the central nervous system. BACKGROUND Tauopathies...

Published: 3/27/2026 | Updated: 3/26/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, Gene therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

β-Catenin agonists recapitulate the protective effects of genetic stabilization

This technology uses drugs that stabilize β-catenin to boost protective immune cells in the lungs, reducing damage from pulmonary hemorrhage and inflammatory lung diseases by activating a novel immunomodulatory pathway. Background: Pulmonary hemorrhage and other inflammatory lung diseases represent significant clinical challenges due to their...

Published: 4/22/2026 | Updated: 3/24/2026 | Inventor(s): Mobin Karimi

Keywords(s): gene coding, gene therapies, gene therapy, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering

A novel synthetic constitutive-active glucocorticoid receptor

Introducing "superGR," a novel synthetic glucocorticoid receptor fusion protein designed to enhance glucocorticoid therapy by providing ligand-independent activation and improved gene regulation for inflammatory diseases. Background: Glucocorticoids are widely used to treat inflammatory conditions like severe alcoholic hepatitis and sepsis,...

Published: 3/9/2026 | Updated: 2/19/2026 | Inventor(s): Hong Lu, Conor Fahy

Keywords(s): gene therapy, glucocorticoid, inflammatory liver disease, lung injury, sepsis, synthetic materials, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering

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