Search Results - microfluidics

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Microfluidic Intravital Window
­A self-contained device that facilitates simultaneous in vivo viewing and remotely controlled fluid delivery to the target tissue. Background: Research has led to a new understanding of how tumor microenvironment heterogeneity presents delivery barriers that hamper the effectiveness of cancer treatments. High-resolution imaging can identify,...
Published: 6/26/2026   |   Updated: 6/26/2026   |   Inventor(s): James Castracane, Logan Butt, Lauren Sfakis, Dave Entenberg, John Condeelis
Keywords(s): Microfluidics, Technologies
Category(s): Technology Classifications > Imaging, Campus > University at Albany
Image-Based Soft-Sensor Approach to Automate Microfluidic Control
Leveraging open-source AI platforms, this technology enables automated image-based detection, prediction, and control of microfluidic single bubble/droplet formation. Problem: Given the incorporation of microfluidic bubble/droplet generation in many applications of science and medicine, improving their high-quality throughout with minimal human intervention...
Published: 6/30/2026   |   Updated: 6/15/2026   |   Inventor(s): Daeyeon Lee, Owen Land, Warren Seider
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Imaging Agents, Microfluidics, Soft Materials, Software
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Diagnostics, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents, Technology Classifications > Robotics, Technology Classifications > Medical Devices
Device For Rapid, Tunable, And Scalable Generation Of Lipid Nanoparticle Formulations
Microfluidic device for generation of large, precisely-defined, diverse lipid nanoparticle libraries for screening LNP formulations. Problem: Lipid nanoparticles (LNPs) have broad applications such as delivery agents for gene editing cargo, immunotherapies, and many clinical applications. The structures of the lipid components of an LNP, their relative...
Published: 4/17/2026   |   Updated: 4/17/2026   |   Inventor(s): Michael Mitchell, David Issadore, Andrew Hanna
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Immunology, Immunotherapy, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Hardware & Components, Technology Classifications > Robotics
A Method for One-Step, Aqueous Phase Generation of Ultrasmall Inorganic Nanoparticles for Biomedical Applications.
A method to generate homogenous and stable inorganic nanoparticles (NPs) using a microfluidic device with two jet inlets. Problem: Inorganic nanoparticles have promise as contrast agents and therapeutics due to their high renal clearance and therefore low toxicity. However, they are limited by factors including complex synthesis routes with unfavorable...
Published: 1/21/2026   |   Updated: 1/20/2026   |   Inventor(s): David Cormode, Hyun (Michel) Koo, Nil Kanatha Pandey, Andrea Kian, Portia Maidment, Derick Rosario Berrios
Keywords(s): Microfluidics, Platform Technology, Radiology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
An Acoustic Device for Large Area Single Cell Trapping and Selective Release (Case No. 2025-047)
Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed an acoustic microfluidic platform that offers a cost-effective and practical approach for handling individual cells at the microscale. Background: Single-cell manipulation is essential for understanding cellular behavior, disease progression, and therapeutic...
Published: 1/13/2026   |   Updated: 1/13/2026   |   Inventor(s): Pei-Yu Chiou, Xiang Zhang
Keywords(s): acoustic microfluidics, acoustic potential wells, acoustics, cell proliferation, cell viability, Diagnostic Platform Technologies (E.G. Microfluidics), diagnostic platforms, Digital Microfluidics, disposable microfluidic platforms, high throughput, high throughput assays, high throughput testing, High-Content Screening, high-throughput cell handling, low-cost fabrication, MEMS, MEMS metasurface, micro-electromechanical systems (MEMS), Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, near-infrared laser, photolithography-free fabrication, research instrumentation, scalable platform, single cell analysis, single cell analysis and testing, Single cell data, single-cell handling, single-cell manipulation, single-cell resolution, single-cell trapping
Category(s): Chemical, Chemical > Chemical Processing & Manufacturing, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Life Science Research Tools, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods, Mechanical, Mechanical > Instrumentation, Platforms, Platforms > Diagnostic Platform Technologies
Closed-Loop Implantable System for Automated Opioid Overdose Detection and Reversal
NU 2019-073 INVENTORS John Rogers (Northwestern University)* Robert Gereau (Washington University, St Louis)* SHORT DESCRIPTION This wireless device, the size of a pacemaker, is implanted to monitor oxygen levels. Below a specific threshold, it sends an alert to warning notification on a mobile app, then automatically releases naloxone to prevent...
Published: 12/9/2025   |   Updated: 11/7/2025   |   Inventor(s):  
Keywords(s): Drug delivery, Electronics & Circuits, Medical device, Microfluidics
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
Ultrasensitive, High-Throughput, Single-Scale Detection of Extracellular Vesicles
An optofluidic platform to detect extracellular vesicles (EVs) at the single-particle level by parallelizing droplet generation and analysis of EVs. Problem: Extracellular vesicles (EVs) are lipid bound nanomaterials carrying various molecular cargo that can be representative of their cells of origin. EVs play a critical role in intercellular communication...
Published: 9/10/2025   |   Updated: 9/10/2025   |   Inventor(s): David Issadore, Zijian Yang
Keywords(s): Bioengineering, Microfluidics, Optics & Photonics , Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
LNP + Squeeze: Enhancing Chimeric Antigen Receptor T-Cell Generation via Mechanoporation and Lipid Nanoparticles
Synergistic combination of mechanoporation and lipid nanoparticle (LNP) based transfection for an efficient, non-viral method of gene transfer to generate CAR-T cell therapies. Problem: Chimeric antigen receptor (CAR)-T cell therapy has transformed cancer treatment by engineering patients' T cells to precisely target and eradicate cancer cells....
Published: 8/28/2025   |   Updated: 8/28/2025   |   Inventor(s): Jina Ko, Jianhua Lim
Keywords(s): Bioengineering, Cell Therapy, Gene Editing, Immunology, Immunoncology, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis
Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 10/20/2025   |   Updated: 7/29/2025   |   Inventor(s): Dino Di Carlo, Alyssa Arnheim, Michael Mellody, Yuta Nakagawa, Lily Shang
Keywords(s): Assay, B Cell, barcode, Bioassay, biological assays, Biomarker, biomarkers, Biomaterial, capping particles, CAR-T cell platform, CAR-T cell therapy, cavities, cavity-containing particles, Cell and tissue culture, cell encapsulation, cell engineering, cell imaging, cell mapping, cell sorting, cell type identification, cell-based therapy, centrifugation, confinement, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, Drug, Drug Delivery, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, Immunoassay, Immunoassay Sense (Molecular Biology), Microfluidics, Microfluidics And Mem's, Microfluidics Nanosphere, microparticles, moieties, Nanoparticle, single cell analysis, single cell analysis and testing, Single cell data, single-cell resolution, single-cell trapping
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Platforms
Micro-channels, Micro-mixers and Micro-reactors
Microreactor architectures for mixing, reactions, and/or heat exchange Background Microfluidic systems and micro-reactors have emerged as promising platforms for precise, small-scale fluid processing. Microfluidic systems offer reduced reagent use, enhanced control over reaction kinetics, and improved safety through process intensification. However,...
Published: 4/16/2026   |   Updated: 6/23/2025   |   Inventor(s): Richard Miller
Keywords(s): Advanced Technology and Manufacturing Inst. (ATAMI), Microfluidics
Category(s): Nanoscience & Microtechnologies, Engineering, Materials Science
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