Search Results - bioengineering

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clampFISH 2.0: Fast, Cost-Effective RNA Detection Using Potent Fluorescent Probes
Molecular diagnostic using clamping fluorescent probes to amplify RNA detection signal of single-cell assay Problem: The molecular diagnostics market is expected to reach $13 billion by 2024, including cancer detection, blood screening, histology assays, tests for transplant compatibility, and inherited and infectious diseases (The World Market for...
Published: 6/29/2026   |   Updated: 6/26/2026   |   Inventor(s): Arjun Raj, Ian Dardani, Benjamin Emert, Sara Rouhanifard
Keywords(s): Bioengineering, Infectious Disease, Nanotechnology, Oncology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Diagnostics
An Implantable Device for Restoring Muscle Function in Nerve or Muscle Impairment
A neuroprosthetic implant that uses existing nerve or muscle signals to replace damaged muscle and restores movement Problem: While prosthetics often replace entire limbs, smaller nerve or muscle injuries are common, severely impact daily life, and have limited treatment options. Facial paralysis is one example, where nerve damage causes muscle weakness,...
Published: 6/26/2026   |   Updated: 6/25/2026   |   Inventor(s): Niv Milbar, Cynthia Sung, Flavia Vitale, Gabriel Unger, Raghav Garg
Keywords(s): Bioengineering, Neurodegenerative Diseases, Neurology, Surgery
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Robotics
Procedure for Pre-Clinical Continuous EEG/ECG Monitoring
This technology introduces a novel surgical procedure, custom implant, and wiring harness for continuous electroencephalogram (EEG) and electrocardiogram (ECG) monitoring in conscious unrestrained animals. The animal is chronically implanted with subdermal electrodes and connected to a durable wiring system to capture high-quality physiological data....
Published: 6/29/2026   |   Updated: 6/24/2026   |   Inventor(s): David Auerbach, Kyle Wagner, Laura Williams
Keywords(s): animal models, animal studies, bioengineering, biomedical science, biosensor, electrocardiogram, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Diagnostics
Durable cure for Pseudoxanthoma Elasticum: High-Efficiency, Precision-Targeted Gene Therapy
Lipid nanoparticles containing messenger RNA (mRNA-LNPs) encoding Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) base-editors that correct pseudoxanthoma elasticum-causing mutations. Problem: Pseudoxanthoma elasticum (PXE) is a genetic disorder affecting approximately 1 in 25,000 Americans. It is caused by loss-of-function mutations...
Published: 6/17/2026   |   Updated: 6/17/2026   |   Inventor(s): Xiao Wang, Hanbing Cao
Keywords(s): Bioengineering, Cardiovascular, Gene Editing, Gene Therapy, Genetic Disorders, Orphan Disease
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
A Fast And Cost-Effective Method For Early Cancer Detection
A quick and inexpensive method to detect cancer early by exponentially amplifying rare and scarce cancer mutations. Problem: Early cancer detection is challenging due to the low levels of cancer-indicating mutant DNA compared to healthy, wild-type DNA. The background noise from the substantial amounts of healthy DNA overwhelms mutant signals. Some...
Published: 6/12/2026   |   Updated: 6/12/2026   |   Inventor(s): Haim Bau, Jinzhao Song, Junman Chen
Keywords(s): Bioengineering, Gene Editing, Gene Therapy, Oncology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents
Fast, On-Demand Manufacturing of Room Temperature-Stable RNA
A method enabling facile synthesis and purification of RNA in a stable format that does not require cold chain distribution. Problem: The cold storage conditions required in the distribution of RNA-based therapies presents a major roadblock toward expanding the utility of these medicines. RNA is susceptible to degradation in aqueous environment and...
Published: 6/11/2026   |   Updated: 6/11/2026   |   Inventor(s): Daeyeon Lee, Kathleen Stebe, Masoud Soroush, Dimitrios Papavassiliou
Keywords(s): Bioengineering, COVID-19, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Microfluidic Lung Chip For Development Modeling
A microfluidic lung chip applies controlled mechanical forces to hydrogel-embedded lung cells or organoids to model lung development in vitro. Problem: Developing lung tissues experiences dynamic mechanical forces during organogenesis. How these forces influence later-stage lung development remains poorly understood. Existing models have not adequately...
Published: 6/10/2026   |   Updated: 6/10/2026   |   Inventor(s): Sunghee Estelle Park, Barry Cooperman
Keywords(s): Bioengineering, Pulmonary
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents
Cardiovascular Assist Device Improving Circulation In Patients With Congenital Heart Disease Undergoing The Fontan Procedure
Valveless pump device implanted during the Fontan surgical procedure in patients with single-ventricle congenital heart disease. Problem: The Fontan procedure is a lifesaving surgery for patients with single-ventricle congenital heart disease, where only one chamber of the heart is functional. The operation reroutes blood flow from the heart to the...
Published: 6/4/2026   |   Updated: 6/4/2026   |   Inventor(s): Cynthia Sung, Jordan Raney, Gabriel Unger, Saheli Patel, Benjamin Kozyak
Keywords(s): Bioengineering, Cardiovascular, Pulmonary, Soft Materials, Surgery
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Robotics
Blood-Brain Barrier and Neurovascular Unit-on-a-Chip Device
A microfluidic chip that models blood-brain barrier biology using brain vascular and supporting cells, with optional neural progenitors and controlled agent exposure and mechanical stretching capabilities. Tech Title: Technology: Technology: The chip includes a bottom region with a center channel adjacent to at least one side channel, and an upper...
Published: 6/5/2026   |   Updated: 5/29/2026   |   Inventor(s): Sezin Aday Aydin, Dongeun (dan) Huh
Keywords(s): Bioengineering, Drug Delivery
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents
Ultrafast, Sensitive, And Long-Lasting Bioelectrochemical Transistors
Supramolecular crown ethers and fluorinated polymers enable the formation of high ionic conductivity, water-impermeable artificial ion channels for bioelectronic transistor applications. Problem: Organic electrochemical transistors (OECTs) are central to bioelectronics by enabling sensitive amplification of weak biological signals through ionic-electronic...
Published: 5/28/2026   |   Updated: 5/28/2026   |   Inventor(s): Yuanwen Jiang, Yuhui Wang
Keywords(s): Bioengineering, Electronic Materials, Nanotechnology, Neurodegenerative Diseases, Neurology, Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Hardware & Components, Technology Classifications > Materials, Technology Classifications > Medical Devices
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