Search Results - cardiovascular

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Durable cure for Pseudoxanthoma Elasticum: High-Efficiency, Precision-Targeted Gene Therapy
Lipid nanoparticles containing messenger RNA (mRNA-LNPs) encoding Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) base-editors that correct pseudoxanthoma elasticum-causing mutations. Problem: Pseudoxanthoma elasticum (PXE) is a genetic disorder affecting approximately 1 in 25,000 Americans. It is caused by loss-of-function mutations...
Published: 6/17/2026   |   Updated: 6/17/2026   |   Inventor(s): Xiao Wang, Hanbing Cao
Keywords(s): Bioengineering, Cardiovascular, Gene Editing, Gene Therapy, Genetic Disorders, Orphan Disease
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Targeted Delivery of Noble Gases via Microbubbles for Organ-Specific Therapeutic and Imaging Applications
Phospholipid encapsulation enables enhanced ultrasound contrast and localized delivery of therapeutic gases following hypoxic-ischemic injury. Problem: Noble gases such as xenon (Xe), Argon (Ar) and helium (He) are known to provide cardioprotective and neuroprotective effects in hypoxic-ischemic injuries, traumatic brain injury and post-cardiac arrest....
Published: 6/16/2026   |   Updated: 6/16/2026   |   Inventor(s): Rajarshi Chattaraj, Daeyeon Lee, Chandra Sandy Sehgal, Daniel Hammer
Keywords(s): Cardiovascular, Imaging Agents, Soft Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Imaging, Technology Classifications > Therapeutics
Methods and Compositions for Prevention and Mitigation of Radiation-Induced Cardiac Injury Using GLP-1 Receptor Agonists
This technology utilizes glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide, to prevent and treat radiation-induced cardiac injury, offering a novel medical approach to protect the heart from damages caused by ionizing radiation. Background: Radiation-induced heart disease (RIHD) is a serious complication arising from exposure...
Published: 6/22/2026   |   Updated: 6/12/2026   |   Inventor(s): Snehalata Pawar, Suresh Veeraperumal
Keywords(s): cardiovascular, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Cardiovascular Assist Device Improving Circulation In Patients With Congenital Heart Disease Undergoing The Fontan Procedure
Valveless pump device implanted during the Fontan surgical procedure in patients with single-ventricle congenital heart disease. Problem: The Fontan procedure is a lifesaving surgery for patients with single-ventricle congenital heart disease, where only one chamber of the heart is functional. The operation reroutes blood flow from the heart to the...
Published: 6/4/2026   |   Updated: 6/4/2026   |   Inventor(s): Cynthia Sung, Jordan Raney, Gabriel Unger, Saheli Patel, Benjamin Kozyak
Keywords(s): Bioengineering, Cardiovascular, Pulmonary, Soft Materials, Surgery
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Robotics
Interoceptomimetics: Dietary Supplements to Enhance Exercise Motivation and Performance
Enhancing exercise performance by modulating the activity of motivation-generating brain regions via stimulation of cannabinoid (CB1) receptors of the enteric nervous system. Problem: An increase in sedentary lifestyles driven by the modernization of society has led to a surge in several metabolic and neurological diseases worldwide. Although exercise...
Published: 4/30/2026   |   Updated: 4/30/2026   |   Inventor(s): Christoph Thaiss, John Nicholas Betley
Keywords(s): Aging, Cardiovascular, Healthcare IT, Microbiome, Neurology, Obesity Metabolic Disease and Diabetes, Regenerative Medicine, Small Molecule
Category(s): Technology Classifications > Food Science and Nutrition, Technology Classifications > Therapeutics
Novel Lipid Lowering, Anti-Atherosclerosis and Anti-Obesity Effects of Netrin-1 (UCLA Case No. 2019-728)
UCLA researchers in the Department of Anesthesiology have developed a novel and extremely robust lipid lowering, anti-atherosclerotic, and anti-obesity treatment with Netrin-1.BACKGROUND:Hyperlipidemia, an elevation of different forms of lipids in the bloodstream, is the most important risk factor for coronary heart disease, while causing many other...
Published: 3/26/2026   |   Updated: 3/26/2026   |   Inventor(s): Hua Cai
Keywords(s): Cardiovascular, Hematology, Therapeutics & Vaccines
Category(s): Therapeutics > Cardiovascular, Therapeutics > Hematology
Deep Learning-Enhanced Dual-Mode Multiplexed Optical Sensor for Point-Of-Care Diagnostics of Cardiovascular Diseases (Case No. 2026-178)
Summary: UCLA researchers in the Departments of Electrical and Computer Engineering and Bioengineering have developed a deep-learning-enhanced multiplexed optical biosensing platform that enables rapid, high sensitivity point-of-care quantification of multiple cardiac biomarkers for cardiovascular diagnostics. Background: Rapid and accessible cardiac...
Published: 3/24/2026   |   Updated: 3/24/2026   |   Inventor(s): Aydogan Ozcan, Dino Di Carlo, Gyeo-Re Han, Artem Goncharov, Merve Eryilmaz
Keywords(s): Biomarker, biomarkers, Cardiovascular, Cardiovascular Disease, cardiovascular diseases, cardiovascular monitoring, cardiovascular therapeutic solution, Deep Learning, Deep learning-based sensing, deep neural networks (DNN), neural network, neural networks, Optics, Point Of Care, point-of-care, point-of-care testing
Category(s): Electrical, Optics & Photonics, Diagnostic Markers, Medical Devices > Cardiac, Medical Devices
Mechanically Tunable Engineered Heart Tissue Platform
Next-generation engineered heart tissue platform that enables precise tuning of mechanical properties of microenvironment to study the structure, development, and function of cultured cells or human-derived cardiac tissues. Problem: Engineering heart tissue (EHT) platforms have the potential to study heart physiology, disease pathology, and therapeutic...
Published: 1/30/2026   |   Updated: 1/30/2026   |   Inventor(s): Kenneth Margulies, Benjamin Lee, Nesrine Bouhrira
Keywords(s): Bioengineering, Cardiovascular, Drug Target, Platform Technology
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Instant, Calibration-Free Blood-Flow Measurement With A Single Optical Snapshot
A single-frame, multi-exposure time optical method enabling accurate extraction of absolute speckle decorrelation time and optimized for recovery of absolute deep-tissue blood flow. Problem: Accurately recovering absolute speckle decorrelation time without the use of calibration or complex instrumentation is challenging. For the use case of monitoring...
Published: 1/8/2026   |   Updated: 1/8/2026   |   Inventor(s): Arjun Yodh, Wesley Baker, Joseph Majeski, Rodrigo Menezes Forti
Keywords(s): Bioengineering, Cardiovascular, Electronic Materials, Gastroenterology, Internet of Things, Nephrology and Urology, Neurology, Oncology, Ophthalmology, Optics & Photonics , Platform Technology, Surgery
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Diagnostics, Technology Classifications > Digital Health, Technology Classifications > Hardware & Components, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents, Technology Classifications > Medical Devices, Technology Classifications > Testing & Measurement
Phenotyping Single Ventricle Physiology Using Electronic Health Records (Case Nos. 2025-322 and 2025-323)
Summary: UCLA researchers have created a cutting-edge, automated phenotyping tool that harnesses electronic health records to enable rapid and precise identification of single ventricle physiology (SVP), especially in neonatal and pediatric populations. Background: Single ventricle physiology (SVP) is a rare heart condition that develops before birth...
Published: 1/6/2026   |   Updated: 12/18/2025   |   Inventor(s): Kim-Lien Nguyen, William Hsu, Hang Xu
Keywords(s): Algorithm, cardiac cycle, Cardiovascular, Cardiovascular Disease, cardiovascular diseases, cardiovascular monitoring, cardiovascular prediction, Computer-Aided Diagnosis, heart disease mitigation, heart support, medical automation technology, Medical Device, medical device cardiac monitoring, Medical diagnostics, Medical Guideline, non-invasive cardiac monitoring, Smart medical device, Software, Software & Algorithms, Software Development Tools
Category(s): Diagnostic Markers, Medical Devices, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems
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