Latest technologies from Canberra IP

Non-Invasive Molecular Diagnostic Platform for Multiple Sclerosis

dragos@northwestern.edu — Tue, 30 Jun 2026 20:57:11 GMT

SHORT DESCRIPTION
A non-invasive blood biomarker technology that analyzes plasma cfDNA methylation to diagnose multiple sclerosis, classify its subtypes, and predict disease progression.

INVENTORS

Yaping Liu* (Northwestern University)
Zongqi Xia* (University of Pittsburgh)

* Principal Investigator

NU Tech ID NU 2025-030

IP STATUS

US Patent Pending (Joint with University of Pittsburgh)

DEVELOPMENT STAGE

TRL-4: Prototype Validated in Lab: Key functions have been demonstrated in controlled laboratory settings using clinical datasets.

BACKGROUND
Multiple sclerosis (MS) is a chronic autoimmune disease caused by inflammatory demyelination of nerve fibers that results in damage to the central nervous system. MS is a highly heterogenous disease with diverse clinical courses, posing significant challenges for early diagnosis, subtype classification, and long-term prognostic prediction. Most individuals are initially diagnosed with Relapsing-Remitting MS (RRMS), defined by discrete episodes of acute neurological symptoms followed by partial or full recovery. Some individuals will subsequently transition to Secondary Progressive MS (SPMS) and a small subpopulation of patients develop Primary Progressive MS (PPMS) from the onset. Patients with progressive MS (PMS), including both PPMS and SPMS, experience worsening neurological impairment without discrete periods of relapse or remission. Timely diagnosis and subclassification is key for developing appropriate treatment plans, which may include disease-modifying therapies (DMTs) that have been approved to treat RRMS. Current diagnostic methods rely on magnetic resonance imaging and invasive cerebrospinal fluid (CSF) analysis, which can be costly, difficult to access, and uncomfortable for patients. Existing blood biomarkers do not fully capture the disease’s complex pathology, resulting in suboptimal treatment decisions. There remains a pressing need for non-invasive diagnostic tools to enable rapid and accurate MS classification and prognosis for personalized patient monitoring and treatment.

ABSTRACT
Northwestern and University of Pittsburgh researchers have developed a highly accurate molecular diagnostic platform that uses cell-free DNA (cfDNA) methylation profiles from patient plasma to identify current disease state and predict disease outcome. This technology utilizes whole-genome bisulfite sequencing (WGBS) of plasma cfDNA to identify specific epigenetic signatures that distinguish MS patients from healthy individuals, differentiate clinical subtypes, and stratify patients by disease severity. The system incorporates computational deconvolution using reference methylation atlases to perform tissue-of-origin (TOO) analysis, estimating the cellular sources of circulating cfDNA. Supervised machine learning classifiers trained on these epigenetic signatures and TOO features categorize disease states, while a linear mixed-effects model calculates a methylation-based prognostic risk score (MBPRS) from baseline methylation at specific prognostic regions to predict future disability progression. Initial validation of the diagnostic platform using clinical datasets shows superior performance compared to existing biomarkers such as neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP). The approach provides a single, comprehensive assay to non-invasively and simultaneously diagnose MS, stratify patients by severity, and accurately forecast long-term outcomes.

APPLICATIONS

Clinical diagnostics and disease management: Allows optimization of patient care through comprehensive, non-invasive diagnosis, MS subtype differentiation, and disease outcome prediction.
Clinical trial patient stratification: Enables accurate selection and stratification of MS patients by subtype and progression risk, ensuring more targeted and effective clinical trials for new therapies.
Therapeutic guidance: Assists in selecting appropriate disease-modifying therapies and provides monitoring tool to evaluate real-time efficacy of treatment.

ADVANTAGES

Minimally invasive: Relies on blood sample instead of MRI or cerebrospinal fluid analysis.
Enhanced diagnostic accuracy: Provides sensitive differentiation of MS subtypes.
Early detection: Enables timely and accurate disease subtype classification.
Cost-effective: Reduces diagnostic expenses compared to standard methods.

PUBLICATIONS

Fu H, Huang K, Zhu W, Zhang L, Bandaru R, Venkatesh S, Walker E, Wang L, Liu Y, Xia Z. Circulating cell-free DNA methylation profiles as noninvasive multiple sclerosis biomarkers: A proof-of-concept study. medRxiv [Preprint]. 2025 Jun 28:2025.02.14.25322180. doi: 10.1101/2025.02.14.25322180.

KEYWORDS
cfDNA methylation, multiple sclerosis, noninvasive diagnosis, blood biomarkers, machine learning, prognosis, neurodegeneration

MICROSCOPE INCLUDING INTERFEROMETER

heguangm@msu.edu — Tue, 30 Jun 2026 20:56:37 GMT

VALUE PROPOSITION

This technology lies in its ability to provide high-quality, 3D imaging of samples with significant surface offsets from a nominal plane, while maintaining spatial resolution. By employing a microscope with an interferometer and utilizing single-shot, polarization-sensitive detection this system offers advantages over conventional devices. These advantages include the elimination of vibration and drift, quick acquisition of interference patterns, and the ability to observe a variety of samples with ease. The use of phase-shifting interferometry ensures high-quality images, while the low-coherence light used minimizes speckles and interference not directly related to the sample.

DESCRIPTION OF TECHNOLOGY

This technology is a microscope system and method that utilizes an interferometer to provide high-quality, 3D imaging of samples with significant surface offsets from a nominal plane. The system employs a microscope with an interferometer, tilting a reference mirror and/or offsetting the sample from the centerline of an adjacent objective or telescope lens. A key feature of this system is the simultaneous detection of a fringe pattern with a phase-shift using light polarization in a single-shot. This approach utilizes an interferometer, with ability to eliminate vibration and drift, quick acquisition of interference patterns, and the ability to observe a variety of samples with ease. The system is particularly beneficial for measuring or imaging samples with complex surface shapes, such as steeply projecting pyramids, cylinders, or other polygons, and can achieve a spatial resolution of about 10 nm, with the potential to reach 0.3 nm with an atomically flat reference mirror.

BENEFITS

High-quality 3D imaging
Single-shot, polarization-sensitive detection
Elimination of speckles and interference
Minimized vibration and drift
Easy sample observation
Compatibility with short wavelength light

APPLICATIONS

Surface profiling
Thin film analysis
Microelectronics inspection
Material characterization
Biomedical research
Quality control

IP Status

US Patent Pending

LICENSING RIGHTS AVAILABLE

Full licensing rights available

Inventors: Marcos DANTUS and Sergei ANISHCHIK

Tech ID: TEC2022-0135

For more information about this technology,

Contact Jon Debling, Ph.D. at deblingj@msu.edu or +1-517-884-1653

Unobservable Re-authentication for Smartphones

ip@skysonginnovations.com — Tue, 30 Jun 2026 19:40:25 GMT

Smart phones are very popular and used by over seven billion people. Each day seven million dollars worth of cell phones is lost or stolen. Without an authentication device, personal data stored on the device can be used for identity theft or the phone can be used for unauthorized purposes. Most authentication systems authenticate a user only once when he logs in to the device. These systems require inputting a password to unlock the device and do not provide periodic re-authentication. Unfortunately, this allows an un-authorized user full access to the device until it is shut off. There is a need for a re-authentication system that is convenient to use. Most re-authentication systems that are currently available require a user to constantly input passwords inconveniencing the user.

Researchers at Arizona State University have developed an authentication system for handheld devices. Once a user is authenticated, the system continually re-authenticates to insure only authorized use of the device. The gestures used by each person to operate a handheld device are unique, like a fingerprint. The system monitors the way the keystrokes are done and the amount of pressure used in keystrokes and taps. The system saves information about the user’s gestures and uses that information as a standard for re-authentication. When an unauthorized user operates the device, the system detects a different user. Additional authentication is needed to reactivate the device. Re-authentication is invisible to users and causes no inconvenience.

Potential Applications

Cell phones
Note pads
Electronic tablets

Benefits and Advantages

Convenient – Re-authentication not noticeable to user
More Power – Constantly re-authenticates user
Retrofit – Works with existing handheld devices
Low Cost – No additional hardware needed

For more information about the inventor(s) and their research, please see
Dr. Guoliang Xue's directory webpage

Cross-Network Compatible Streaming Using Independent Filename-Indexed Video Segments

ip@skysonginnovations.com — Tue, 30 Jun 2026 19:24:01 GMT

Hypertext Transfer Protocol (HTTP) transfers information across the World Wide Web by routing packets of data from the web’s most available servers to a client, whose browser then builds a webpage (or streams media) from those packets. MPEG’s Dynamic Adaptive Streaming over HTTP (DASH), Apple’s HTTP Live Streaming, Microsoft Smooth Streaming, and Adobe’s HTTP Dynamic streaming, are all multimedia distribution protocols that help reduce buffering caused by intermittent HTTP data transfer. These protocols work by downloading the best available image quality that can be transferred before playback based upon the available bandwidth, while referencing a front-end list file containing metadata (data that describes other data) that serves as directions for where to find the data and how to assemble the video. These list files must be compatible with browsers, often requiring complex plugins and codecs that invite security vulnerabilities or have very limited cross-platform support. Additionally, current DASH players can only interact with video servers operating on TCP/IP protocol stacks, making them incompatible with non-TCP/IP networks such as WiFi, Bluetooth, and ZigBee used by wireless video sensors and camera-integrated consumer electronics.

Researchers at ASU have developed a method for generating, storing, and distributing video between dissimilar network protocols by using independently playable video segments whose filenames are uniquely indexed with identification and compilation information. The length of the segments can be adjusted from zero to thirty seconds and each segment contains all video formatting information needed for playback. The framework includes a media player build upon only the core elements of HTML5. The interim client-side storage of the HTML5 File System enables streaming from non-TCP/IP networks directly to the HTML5 canvas, transferring the CPU workload from a mobile sensor network to whatever client device is hosting the media player. Since the indexed filenames provide all the HTML5 video tags necessary for compiled playback, metadata list files are no longer required (but are still optional), eliminating the need for outside browser plugins or video codecs.

Potential Applications

Information-Centric Network Services/Streaming
Mobile Device Cameras
Multimedia Streaming/Playback
Wireless Video Sensor Networks

Benefits and Advantages

Efficient – Saves power and bandwidth by transferring CPU workload away from mobile network devices that have limited processing power.
Innovative – Permits streaming from non-TCP/IP networks such as WiFi, Bluetooth, and ZigBee.
Practical – Does not require a metadata list file as filenames provide the all the necessary indexing for playback.
Versatile
- Video can be any file format.
- Can be implemented via hardware or software.
Secure – Does not require any outside plugins or codecs.

For more information about the inventor(s) and their research, please see

Dr. Martin Reisslein's directory webpage

CONCEALING ALGORITHM LOGIC IN SECURE HOMOMORPHIC COMPUTATION

heguangm@msu.edu — Tue, 30 Jun 2026 19:20:01 GMT

VAlue proposition

This technology, PrivaCT, offers a significant value proposition in the realm of data privacy and security. By leveraging fully homomorphic encryption (FHE), PrivaCT enables computations to be performed on encrypted data without the need for decryption, thereby preserving data confidentiality. What sets PrivaCT apart is its innovative approach to protecting not just the data but also the functions applied to it. Traditional FHE methods often evaluate functions in cleartext, which can expose proprietary algorithms and make them vulnerable to side-channel attacks. PrivaCT addresses this by transforming private internal circuits into uniform external circuits, thereby eliminating any information about the underlying function. By offering a scalable and efficient solution for secure computation, PrivaCT establishes a new benchmark for privacy-preserving computation, making it an invaluable tool for industries that require robust data and algorithm confidentiality.

Description of Technology

The core innovation of PrivaCT lies in its ability to transform private internal circuits into uniform external circuits, effectively concealing the specifics of the underlying functions through a two-stage approximation process. This process involves using a universal function approximator to capture the function's behavior and then decomposing it into scalar components, each approximated by univariate methods. This strategy not only maintains high accuracy but also ensures a constant runtime, making PrivaCT highly efficient. This makes PrivaCT particularly valuable for industries such as healthcare, where the confidentiality of proprietary algorithms and personal data is paramount.

Benefits

Enhanced Data Privacy
Secure Algorithm Confidentiality
High Accuracy and Efficiency
Scalability
Broad Applicability
Resistance to Side-Channel Attacks
Constant Runtime

Applications

Healthcare Data Analysis
Financial Services
Cloud Computing
Supply Chain Management
Scientific Research
Government and Defense

IP Status

Patent Pending

LICENSING RIGHTS AVAILABLE

Full licensing rights available

INVENTORs: Vishnu Boddeti and Amina Bassit

Tech ID: TEC2025-0139

For more information about this technology,

A Model Based non-Invasive Physiological Data Acquisition Technique

ip@skysonginnovations.com — Tue, 30 Jun 2026 18:14:37 GMT

The most advanced Body Sensor Networks (BSNs) consist of wireless electronic sensors that are worn by patients and communicate wirelessly with a smartphone or computer. These sensors can be invasive or they must be put on every time a patient is monitored, which can be especially inconvenient for non-human patients. Currently, no non-invasive method of physiological monitoring exists that does not involve the application of electronic sensors to the skin.

Researchers at Arizona State University have developed a technique to sense physiological signals without installing sensors on a patient. When two people are in close proximity of each other, the electrocardiography (ECG) signal of one person may be coupled to the electroencephalography (EEG) signal of the other person. This non-invasive technique uses math modeling and electrical coupling to read an individual’s ECG through the EEG of whoever is conducting the monitoring.

Potential Applications

Healthcare/Veterinary Care
Biometric Security Systems
Haptics

Benefits and Advantages

Efficiency – Saves doctors and veterinarians the time of applying sensors to a patient and the cost of using multiple devices to monitor each patient.
Efficiency – Saves doctors and veterinarians the time of applying sensors to a patient and the cost of using multiple devices to monitor each patient.
Increased Protection – Additional safeguard when combined with other biometric security devices.

For more information about the inventor(s) and their research, please see
Dr. Sandeep Gupta's directory webpage

Dr. Ayan Banerjee's directory webpage

LookingGlass: Real-Time Contextual Mapping Tool for Tracking Population Movements and Their Drivers

ip@skysonginnovations.com — Tue, 30 Jun 2026 18:06:33 GMT

Current technology for monitoring social media will track frequencies of matching documents for simple, unorganized, keyword lists containing names of groups, individuals, practices, brands, and places. This has left a gap between what society thinks is understood from monitoring and what is actually understood in the complex systems that make up societies. Decision-making at the macro levels of social, political, cultural, and behavioral levels are left to make assumptions. It is also difficult to match individual followers, influencers, and groups to the macro level issues. This problem has made it very difficult to collect and understand data that may point to potential security threats to national interests from behaviors, attitudes, and identities.

Researchers at Arizona State University have developed a real-time, contextual analysis system that models complex socio-political situations that have a large degree of volatility and uncertainty. This innovation enables decision-makers to analyze cultures, attitudes, events, relationships and project potential outcomes. System users have the ability to understand the driving factors of behaviors in complex and dynamic environments by accounting for beliefs, goals, and intentions of influential state and non-state actors, as well as their leaders and followers. The system mines and organizes data to show the sizes and geographic footprints of social-media active groups, links and interactions between groups, lists, locations, and other demographic information about the group’s influential followers, group trends, and provides detailed information about the patterns of any geographic location, group, or individual.

Potential Applications

Detection of potential terrorist threats
Model religious and sectarian extremism and trends
Project anticipatory scenario development and strategic planning for regional instability
Track enemy combatants
Detecting financial fraud

Benefits and Advantages

Fast – Analyzes large amounts of data quickly
Better Decisions – Provides leaders with information and scenarios for potential outcomes to aid in decision-making
Saves Lives – Proactive system allows for rapid response and preemptive action.

For more information about the inventor(s) and their research, please see
Dr. Hasan Davulcu's directory webpage

Dr. Mark Woodward's directory webpage

Dr.Jieping Ye's directory webpage

Dr.Steven Corman's directory webpage

Micro-Miniaturized Passively Powered Wireless Telemetry

ip@skysonginnovations.com — Tue, 30 Jun 2026 17:32:10 GMT

Very small implantable wireless telemetry systems have the potential to become a tool for continuous in vivo biomonitoring, implant monitoring and drug delivery. Such minimally invasive devices may provide a practical way of continuously monitoring of brain and central nervous system function, thusly enabling continuous physiological and biomarker monitoring and supporting the development of man-machine interfaces. Conventional biopotential electrodes with implanted wires are often heavy, cumbersome, and limit a person's mobility. Electrodes that must pass through the skin to contact the brain or nervous system are sites of infection and injury when strained.

In an exciting development at ASU, Dr. Bruce Towe has invented a simple strategy to achieve wireless biotelemetry through the use of miniature semiconductor varactor parametric amplifiers. The device is excited with an external source of radio frequency signal which causes it to resonate and re-radiate a signal which allows the recovery of a biopotential signal, and does not require an internal power-source. This circuit has the advantage of small size, wide bandwidth, high sensitivity and does not rely on an internal power source.

Potential Applications

The market for biotelemetric devices is poised to grow rapidly, fueled by the need for miniature, implantable devices that can perform a variety of tasks:
- Monitoring heart, brain, nervous system functionality – electrical waveforms of these systems can be recorded through biotelemetry.
- Biochemical and biophysical sensors – Implantable microminiature sensors for pH, pressure, temperature, and osmolarity
- Implant diagnostics – status and device health monitoring of implanted devices (stents, catheters, bio-structural materials and devices).
- Drug delivery – wireless control of implanted drug-release devices

Benefits and Advantages

Small size – can be implanted with a syringe needle
No batteries – powered by external radio frequency
Wireless – no requirement for internal power source (smaller size, very long implant time, no explant required for battery replacement)
Possibility of multichannel, multifrequency operation - reduces quantity of implantable devices to achieve specific tasks
Wide bandwidth/high sensitivity – sensitive to microvolt level modulations, no preamplification necessary

NEURAL NETWORKS WITH HOMOMORPHIC ENCRYPTION

heguangm@msu.edu — Tue, 30 Jun 2026 16:16:16 GMT

VAlue proposition

Deployment of neural inference over encrypted data—using Fully Homomorphic Encryption (FHE) or Secure Multiparty Computation (MPC)—enables privacy-preserving computation crucial for sensitive applications in healthcare, biometrics, finance, and national security. However, encrypted neural inference has significant physical consequences: High power consumption, causing excessive energy use, increased heat, and additional cooling infrastructure. Large hardware footprints requiring increased physical space, server racks, and supporting facilities are needed. There is decreased hardware reliability and lifespan, due to intensive computational loads that accelerate hardware wear. These physical problems exponentially worsen when considering variations across cryptographic schemes, hardware platforms, and neural architectures.

Description of Technology

This technology is an automated optimization system that directly reduces physical resource usage by intelligently generating highly efficient encrypted inference implementations. It specifically achieves: Reduced energy usage by minimizing computational intensity through optimal selection of cryptographic parameters (e.g., bootstrapping frequency, polynomial approximations). Smaller physical footprints through hardware-optimized circuit designs, reducing the number of servers, processors, and related infrastructure needed. Improved hardware lifespan by significantly decreasing computational load and thermal stress on computing components, extending operational reliability.

Benefits

Automated cross-scheme optimization (e.g., CKKS, BGV, TFHE, SPDZ, GMW)
Hardware-aware automated optimization, reducing physical resources (CPUs, GPUs, FPGAs, ASICs)
Adaptive optimization to support emerging cryptographic, hardware, and neural innovations
Physical-resource-centric optimization framework

Applications

Healthcare
Biometrics
Finance
National Security
Cloud Computing

IP Status

Patent Pending

LICENSING RIGHTS AVAILABLE

Full licensing rights available

INVENTORs: Vishnu Boddeti and Wei Ao

Tech ID: TEC2025-0143

For more information about this technology,
contact Jon Debling PhD at deblingj@msu.edu or 1(517)884-1653

NOVEL CIRCULAR PEPTIDES FOR PROTEIN AGGREGATION DISEASES AND AGE-RELATED DISORDERS

tac79@drexel.edu — Tue, 30 Jun 2026 15:55:17 GMT

PAGE TITLE

Overview

PAGE SUMMARY

Developed by Dr. Timothy Cunningham at Drexel University, this innovation is a peptide‑based platform that activates Heat Shock Protein 70 (HSP70) to restore the body’s natural protein quality control systems.

The technology comprises a family of short, bioengineered peptides, most notably CHEC 9, CHEC 7, and the optimized cyclic variant cycloSKEc7 (cSKE7), derived from naturally occurring protein fragments that help regulate cellular stress responses. These peptides work by activating Heat Shock Protein 70 (HSP70), a key “protein quality control” factor in the body that identifies and repairs or removes damaged proteins. In many age related and metabolic conditions, proteins become chemically modified (for example, by excess blood sugar byproducts), causing them to misfold and clump into toxic aggregates known as amyloids that impair normal cell function. The CHEC peptides act as small molecule regulators of HSP70, enhancing its ability to break apart these aggregates and restore protein function.

Earlier versions of the Drexel inventor’s peptides demonstrated anti inflammatory and cell protective effects through this mechanism, while the next generation cSKE7 has been rationally redesigned to improve stability, solubility, and therapeutic practicality. In human plasma models of metabolic stress, these peptides have been shown to disperse existing protein aggregates, inhibit new aggregate formation at very low concentrations, and recover key enzymatic and antioxidant functions, ultimately reducing oxidative stress and inflammation. Together, these properties position this proof-of-concept platform as a novel approach to treating diseases driven by protein damage and aggregation, including metabolic disorders, neurodegenerative conditions, and aging related decline, by restoring the body’s natural protein maintenance systems rather than targeting a single disease pathway.

Supported by early stage preclinical studies in human plasma and related models, the technology is positioned for translational development in treating protein aggregation–driven diseases.

ADVANTAGES

TITLE:Key Advantages

First-in-class mechanism leveraging HSP70 stimulation to directly disperse amyloid and protein aggregates, addressing root causes of proteostasis failure.

Demonstrated nanomolar potency and specificity, enabling effective disaggregation activity at low therapeutic doses.

Capability to reduce oxidative stress and inflammatory markers concomitantly, thereby offering multi-modal therapeutic effects.

Enhanced chemical stability and improved aqueous solubility support formulation development and therapeutic applicability.

Derived from a human endogenous protein, which may support a low immunogenicity profile.

Preclinical studies support translational relevance and therapeutic viability across human plasma and neural models.

Problem Solved

TITLE:Problems Solved

Mitigates accumulation of toxic protein aggregates in blood and neural tissues that contribute to metabolic and neurodegenerative diseases.

Addresses oxidative stress and inflammatory cascades triggered by protein misfolding, which exacerbate cellular damage and disease progression.

Overcomes limitations of current treatments that primarily provide symptomatic relief without targeting aggregate clearance.

Offers a novel therapeutic approach to reduce complications associated with hyperglycemia and aging-related cellular decline.

Supports restoration of enzymatic function and redox balance impaired in metabolic disorder pathologies.

APPLICATIONS

TITLE: Market Applications

Therapeutic intervention in metabolic disorders such as diabetes by mitigating protein aggregation-associated complications.

Treatment of age-related diseases including Alzheimer's, Parkinson's, and other neurodegenerative conditions characterized by proteinopathy.

Life extension therapies aimed at enhancing healthy lifespan through improved systemic proteostasis and reduction of cellular stress markers.

Potential adjunctive treatment in oxidative stress-related organ dysfunctions affecting heart, brain, and other vital organs.

Potential use in clinical settings requiring modulation of inflammatory responses linked to protein aggregation and cellular senescence.

IP STATUS

Intellectual Property and Development Status

Patent pending, PCT application filed

This early stage innovation developed in the Drexel University College of Medicine is available for translational research, testing and licensing opportunities.

PUBLICATIONS

References

Pubinfo should be the citation for your publication. Publink is the full url linking to the publication online or a pdf.

Scientific Publication – “Peptide treatment of human plasma disrupts metabolic and age-related pathologies via heat shock protein 70”

Scientific Publication – “Anti-inflammatory peptide regulates the supply of heat shock protein 70 monomers: implications for aging and age-related disease”

Scientific Publication – “Heptamer Peptide Disassembles Native Amyloid in Human Plasma Through Heat Shock Protein 70”

Commercialization Opportunities
This early stage innovation developed in the Drexel University College of Medicine is available for translational research, testing and licensing opportunities.

----------------------------------------------

Contact Information

For intellectual property and licensing inquiries, please contact Dr. Robin Stears, Director of IP & Agreements, at rls457@drexel.edu or applied_innovation@drexel.edu.

Multiplexing, signal rechanneling and optical powered oscillator

heguangm@msu.edu — Tue, 30 Jun 2026 14:41:14 GMT

VALUE PROPOSITION

For Magnetic Resonance Imaging it is often desirable to measure electrophysical characteristics alongside MRI data. To do so, voltage sensors are employed. This technology is an RF powered voltage sensor which can be configurable to measure a variety of physical indicators with excellent resolution. The design minimizes interference with MRI operations.

DESCRIPTION OF TECHNOLOGY

The parametric resonator is a circular-shaped loop-gap resonator with a continuous center conductor to bridge its virtual grounds. As a result, the resonator has a butterfly resonance mode at a lower frequency and a circular resonance mode at a higher frequency. When a pumping signal is applied at approximately the sum frequency of these two modes, the resonator can oscillate at frequencies that are close to the resonance frequencies of individual modes. Once the pumping signal is determined by an external frequency synthesizer, it will also determine the sum of butterfly and circular oscillation frequencies. If the butterfly mode oscillation signal falls within the detection band of the MRI scanner, it can be detected by a standard MRI coil allowing sensor information to be recorded. This technology has a wireless oscillator that relies on ambient light, rather than Radio Frequency energy.

BENEFITS

Able to record very small changes in neuronal voltage.
Low MRI interference.

APPLICATIONS

Neural Imaging
MRI

IP Status

US Patent Pending

LICENSING RIGHTS AVAILABLE

Full licensing rights available

Inventor: Chunqi Qian

Tech ID: TEC2026-0093

For more information about this technology,

Contact Jon Debling, Ph.D. at deblingj@msu.edu or +1-517-884-1653

Safe and Highly Selective HDAC8 Inhibitors for Kidney Disease and Precision Therapies

lbricha@upenn.edu — Tue, 30 Jun 2026 13:21:49 GMT

HDAC8-targeting small molecules for kidney disease treatment with improved safety, selectivity, and therapeutic potential.
Problem:
Acute kidney injury (AKI) and focal segmental glomerulosclerosis (FSGS) affect millions of patients worldwide and can contribute to chronic kidney disease and end-stage renal failure, which only has a 5-year survival rate of 35-50%. Despite substantial disease burden, there are currently no FDA-approved therapies that directly target underlying molecular drivers of either condition. Existing treatment approaches primarily focus on symptom management and supportive care rather than halting disease progression. As a result, there remains a significant unmet need for therapies that address the root causes of kidney injury and dysfunction.
Solution:
Histone Deacetylase 8 (HDAC8) is a promising therapeutic target for kidney disease due to its role in regulating gene expression pathways associated with inflammation, fibrosis, and renal injury. Targeting HDAC8 can help address drivers of renal disease, slowing its progression. The inventors developed a class of HDAC8 inhibitors that exhibit potent inhibition with improved selectivity compared to conventional HDAC inhibitors.
Technology:
Most HDAC8 inhibitors rely on a hydroxamic acid (HA) zinc-binding group (ZBG) to target the enzyme’s catalytic zinc ion. The inventors developed compounds featuring a distinct ZBG from those used in existing HDAC inhibitor designs, enabling improved selectivity and reduced off-target activity. By leveraging additional interactions beyond the conventional binding pocket, these compounds exhibit potent and selective HDAC8 inhibition. The molecules’ synthesis involves a modular convergent approach that enables rapid generation and optimization of analogs. The resulting compounds achieve HDAC inhibition with half-maximal inhibitory concentration (IC50) values ranging from 0.007 to 50 μM.
Advantages:

Potent HDAC8 inhibition with lead compounds achieving IC50 values as low as 7 nM.
Modular convergent synthesis allowing for rapid generation and evaluation of new compound variants.
Replaces the traditional HA ZBG with an alternative design, reducing reliance on a motif often linked to safety and specificity concerns.
Dual-site engagement of both the catalytic region and a distinct HDAC8 binding pocket to improve target recognition compared to traditional inhibitors that rely solely on the conventional active-site interactions.

Stage of Development:

Preclinical Discovery

Modular design of the HDAC8 inhibitor small-molecule constructs. Left: schematic representation of the molecular architecture consisting of a cap, linker, and ZBG, and acetate release channel interacting domain. Right: representative chemical structure corresponding to each molecular domain.
Intellectual Property:

Provisional Filed

Reference Media:

Long, K et al. ACS Pharmacol. Transl. Sci., 2022 March 16; 5(4): 207
de Groh, ED et al.; J Am Soc Nephrol, 2010 May; 21(5): 794
Donna Huryn Lab
Neil Hukriede Lab

Desired Partnerships:

License
Co-development

Docket #26-11392

Aptamer-Based Molecular Recognition Platform for Targeted Diagnostics and Therapeutic Inhibition of the Pathological Tau Protein in Neurodegenerative Disorders

saradagen@ufl.edu — Mon, 29 Jun 2026 20:14:53 GMT

Enables Site-Specific Detection and Inhibition of Disease-Associated Tau Protein

This aptamer-based molecular recognition platform enables site-specific detection and inhibition of pathological tau protein in neurodegenerative disorders. Tau is a microtubule-associated protein enriched in neuronal axons within the central nervous system. Under normal physiological conditions, tau promotes the assembly and stabilization of microtubules, maintaining neuronal structure and intracellular transport. In several neurodegenerative conditions, tau becomes abnormally phosphorylated, causing it to dissociate from microtubules and aggregate within neurons, disrupting neuronal stability and contributing to neuronal death. Tau pathology is a defining feature of several neurological disorders, including Alzheimer's disease and chronic traumatic encephalopathy (CTE). In the United States, roughly 1.9 million new traumatic brain injury (TBI) cases occur annually, many triggering chronic tau aggregation and accelerate neurodegeneration. The global TBI-diagnostic market was valued at approximately $1.06 billion in 2024 and is projected to exceed $2.5 billion by 2031, reflecting growing demand for rapid and accurate neurological biomarker detection. Existing detecting platforms are costly and require large sample volumes, creating a clear opportunity for a low-cost, high-sensitivity aptamer solution.

Researchers at the University of Florida developed an aptamer platform for enabling the selective recognition of tau and its phosphorylated forms using short, structured DNA sequences engineered for high binding specificity. Aptamers offer several advantages over conventional antibodies, including smaller size, chemical stability, and the ability to be synthetically produced and modified. These properties make them versatile molecular tools for biomarker detection, imaging, and therapeutic targeting, positioning the tau-binding aptamer technology as a promising platform for developing next-generation diagnostics and treatments for tau-related neurological disorders.

Application

This aptamer-based molecular recognition platform can be used in the development of diagnostic assays and therapeutic strategies for detecting and targeting tau pathology associated with neurodegenerative diseases and traumatic brain injury

Advantages

Enables precise recognition of hyperphosphorylated tau variants, increasing diagnostic sensitivity to differentiate between healthy and pathological protein forms
Combines high-fidelity detection with potent inhibition, accelerating early disease detection and halting tau aggregation
Crosses the blood-brain barrier efficiently, delivering diagnostic or therapeutic molecules directly into the brain
Offers smaller sizes than antibodies, improving tissue diffusion
Reduces production cost, allowing chemical synthesis at scale

Technology

The platform uses high-affinity DNA aptamers to specifically target and bind to the tau protein at critical phosphoryl table sites, providing a versatile avenue for the detection and treatment of tauopathy-related neurodegenerative disorders. By enabling the precise recognition of pathological tau forms, the system facilitates early-stage diagnosis and real-time monitoring of disease progression. The platform is compatible with multiple biological matrices, including cerebrospinal fluid and blood, and supports diverse applications such as enzyme-linked aptamer-based assays (ELASA), molecular beacon-based sensing, and targeted therapeutic inhibition of tau aggregation. Designed for clinicians and researchers, this platform improves diagnostic sensitivity, enables the rapid evaluation of neurotoxic protein levels, and provides a programmable, non-immunogenic tool for arresting the progression of conditions like Alzheimer’s disease and CTE without the limitations of traditional antibody-based methods.

AI-Driven Clinical Decision Support System for Diabetes Management

ip@skysonginnovations.com — Mon, 29 Jun 2026 19:30:45 GMT

Invention Description

Type 1 diabetes (T1D) affects nearly 10 million people worldwide and occurs when the immune system destroys the pancreas's insulin-producing beta cells. Managing T1D is notoriously difficult, requiring constant glucose monitoring and precise insulin dosing. Even with advanced tools like continuous glucose monitors (CGMs) and automated insulin delivery (AID) systems, patients still struggle with dysglycemia and would benefit significantly from a deeper understanding of how to fine-tune their insulin doses for optimal blood sugar control.

Researchers at Arizona State University have developed an innovative clinical decision support system which integrates sensors, processors, data communication, and machine learning algorithms to assist clinicians in preventing hyperglycemia in T1D patients. By analyzing continuous glucose monitor and insulin pump data, it offers advanced analytics and simulations to suggest optimal insulin timing and dosage adjustments. This platform features predictive models which are all accessible via an intuitive portal for real-time data visualization and decision-making.

This technology is an AI-powered clinical decision support system designed to optimize diabetes management through actionable insights and advanced glucose control recommendations.

Potential Applications

Companies developing diabetes management software and medical devices
Hospitals and clinics managing type 1 diabetes patients
Endocrinologists and diabetes care specialists
Diabetes research centers and academic institutions
Integrated care platforms seeking AI-driven decision support tools

Benefits and Advantages

Provides actionable recommendations rather than just visualizing data
Utilizes AI-driven predictive models for accurate hyperglycemia forecasting
Enables clinicians to simulate and evaluate the effects of insulin and carbohydrate adjustments
Integrates continuous glucose and insulin data for personalized treatment plans
User-friendly portal streamlines clinical workflows and decision-making

Compiling Error-Corrected Quantum Circuits under Hardware Constraints

JianlingL@tla.arizona.edu — Mon, 29 Jun 2026 17:13:07 GMT

This technology is a method of finding the ideal hardware choices to execute a given quantum algorithm, by explicitly treating compilation within the framework of quantum error-correcting codes and logical operator equivalence in the special unitary group. Quantum hardware is noisy, and certain hardware combinations can be even more so. This technology introduces a systematic method to develop distinct, error-corrected circuits that are logically equivalent to circuits with connectivity or compilation problems.

Background:
Typically, connectivity problems in quantum hardware are addressed by incorporating qubit swap gates, which are expensive. This technology offers a different approach to reducing compilation errors by simply replacing poor-connectivity quantum circuits with logically equivalent circuits that adhere to hardware connectivity.

Applications:

Quantum computing
Quantum hardware
Error-corrected quantum circuits

Advantages:

Reduces cost
Systematic technique
Improving feasibility on constrained quantum hardware

EUV Lithography System Using Segmented Transmissive Projection Optics

JianlingL@tla.arizona.edu — Mon, 29 Jun 2026 17:11:17 GMT

This invention describes a system where extreme ultra-violet (EUV) radiation is patterned and projected onto a wafer using transmissive membrane optics while managing thermal absorption, membrane mechanical stability, and optical obscuration. This enables programmable or mask-based projection lithography using transmissive optical elements.

Background:
Advanced manufacturing increasingly operates at single digit nanometer scales, placing growing demands on imaging systems for resolution, alignment accuracy, throughput, and production time. Established projection designs are near their physical and economic limits, with added complexity causing increased sensitivity to heat, contamination, and mechanical instability. Material constraints and tight geometric requirements further limit design flexibility and weaken traditional scaling methods. Industry responses, such as higher numerical aperture optics, smaller exposure fields, and stricter environmental control, deliver incremental improvements but also raise system complexity and operating risk. To sustain further scaling, manufacturers are shifting toward projection architectures that divide the imaging task into smaller, independently optimized optical sections, reducing the dependence on a single monolithic.

Applications:

Diffractive Fresnel zone plate lenses
Vacuum-guiding metasurfaces
Effective-medium phase structures
Nanophotonics
EUV lithography

Advantages:

Improved manufacturability
Scalability to higher resolution
Reduces phase errors

Non-local EUV Metasurfaces and Reflective Non-local EUV Metalenses

JianlingL@tla.arizona.edu — Mon, 29 Jun 2026 17:10:28 GMT

This invention describes a planar reflective optical platform for extreme ultraviolet wavelengths based on guided-mode resonators in thin-film dielectric waveguides. The invention enables reflective wavefront control, focusing, and aberration correction through nonlocal metasurface physics. This eliminates the need for multilayer Bragg reflectors.

Background:
Extreme ultraviolet (EUV) optical systems often face fundamental challenges arising from material optical properties in this regime because nearly all solid materials exhibit refractive indices slightly below unity with significant absorption at EUV wavelengths. Current systems use Bragg reflector mirrors to achieve 70% reflectivity, but suffer from angular bandwidth limitations, fabrication complexity for focusing elements, and multi-element requirements to compensate for aberrations. There is a persistent need across the field for planar reflective EUV optical elements capable of achieving high numerical imaging and wavefront control without the need for curved multilayer mirror systems due to their complexity, costs, and scalability limitations.

Applications:

Advanced wavefront engineering
EUV imaging
EUV lithography

Advantages:

Reduced angular sensitivity
Single-element aberration correction
Robust
Scalable
Entirely planar structure

Integrated Optical Side-Channel Suppression Architecture for CMOS Devices

JianlingL@tla.arizona.edu — Mon, 29 Jun 2026 17:09:45 GMT

This invention addresses two separate physical leakage pathways in CMOS circuits: mid-infrared thermal emission and near-infrared photon emission. The invention integrates two mechanisms into standard back-end-of-line fabrication processes to provide a unified method for reducing optical side-channel vulnerability without altering the performance of the CMOS logic or requiring changes to front-end device structures.

Background:
Optical side channel attacks exploit unintentionally emitted radiation from integrated circuits to infer internal computational activity. One instance of these attacks occurs when thermal infrared imaging detects minute temperature variations on the chip surface, which reveal patterns that correlate with switching activity. Another instance of these attacks uses near-infrared photon emission produced by hot-carrier recombination during transistor switching. Weak emissions can escape through the backside of a thinned die and be recorded using NIR detectors, enabling spatially resolved observation of logic activity. Existing mitigation techniques focus on packaging-based shielding, chip-level opaque coatings, or algorithmic countermeasures such as randomization and noise injection. These approaches are often costly, limited ineffectiveness, or incompatible with high-performance system requirements.

Applications:

Counter-surveillance
Defense and aerospace
Secure microcontrollers (ATMs, Smartcards)
Payment card, authentication, and identity ecosystems

Advantages:

Protects the most vulnerable surface of a chip
Compatible with existing designs
Low-cost, manufacturable solution
Reduce optical side channel leakage without affecting CMOS logic performance

Methods for Differentiable Characterization of Materials

JianlingL@tla.arizona.edu — Mon, 29 Jun 2026 17:08:39 GMT

Differentiable Characterization of Materials is a software-based approach for analyzing materials microscopy data by converting discrete measurement data into continuous, queryable representations of a material. Instead of limiting analysis to fixed measurement points, this approach allows researchers to study material features across space and extract useful property information from microscopy signals. The technology may help researchers better understand composition, crystal orientation, stress, defects, boundaries, and other material features with greater flexibility than traditional grid-based analysis. It can support higher-resolution review of existing datasets, reduce storage needs by representing large datasets more compactly, and connect characterization data more directly with property prediction and physics-based materials models. This could make materials analysis faster, more informative, and easier to integrate into existing research and commercial microscopy workflows.

Background:
Materials researchers rely on microscopy and microanalysis tools to understand how a material’s structure affects its properties and performance. Current methods often collect data at fixed points or on fixed grids, which can limit how closely researchers can inspect areas between measurement points. These methods can also introduce noise when estimating gradients, boundaries, or other spatial changes in a material. Existing workflows often require separate steps for data collection, data processing, image segmentation, property extraction, and model-based analysis. This can make the process time-consuming and can cause information to be lost between steps. This technology creates a continuous representation of material data, allowing users to query, analyze, compress, and integrate microscopy data with material property models within a more unified software workflow.

Applications:

Materials characterization
Microscopy and microanalysis software
Electron backscatter diffraction analysis
Spectroscopy and diffraction data analysis
Materials informatics

Advantages:

Converts fixed-grid microscopy data into continuous, queryable material representations
Allows users to analyze material features between original measurement points
Supports cleaner extraction of gradients, boundaries, and spatial property changes
May reduce noise compared with traditional finite-difference analysis
Can compress large microscopy datasets for easier storage, sharing, and archiving

GRAPHENE NANORIBBON PHOTOVOLTAICS

heguangm@msu.edu — Mon, 29 Jun 2026 16:21:13 GMT

VAlue proposition

Graphene and graphene nanoribbons (GNRs) offer a compelling value proposition due to their exceptional properties, including high electrical conductivity, mechanical strength, thermal conductivity, and chemical stability. These unique characteristics enable graphene and GNRs to be utilized in a wide range of applications across various industries, such as electronics, energy storage, sensors, biomedical devices, and environmental remediation. By leveraging the potential of graphene and GNRs industries can develop innovative solutions that improve performance, efficiency, and sustainability.

Description of Technology

Graphene and graphene nanoribbons (GNRs) are emerging as promising materials for photovoltaic applications due to their exceptional electrical and mechanical properties, including high carrier mobilities, conductivity, Young's modulus, and tensile strength. By leveraging the tunable bandgap of GNRs, which can be controlled through their width, we have demonstrated the potential of GNRs as photoactive layers in photovoltaic devices. This technology utilizes nonoxidative alkyne benzannulation synthesis for precise GNR width control and fabricates photovoltaic cells that generate photocurrent across the solar spectrum, from the ultraviolet region to the near-infrared.

Benefits

Excellent electronic and mechanical properties
Tunable bandgap
High light absorption
Potential for thin film optoelectronic devices

Applications

Photovoltaics
Energy storage
Sensors
Flexible electronics

IP Status

US Patent Application 18/222,944

LICENSING RIGHTS AVAILABLE

Full licensing rights available

INVENTORs: Richard Lut, Mathew Bates, Ryan Malone and Wesley Chalifoux

Tech ID: TEC2023-0003

For more information about this technology,
contact Jon Debling PhD at deblingj@msu.edu or 1(517)884-1653

COMMUNICATION SYSTEM FOR WIRELESS NETWORKS

heguangm@msu.edu — Mon, 29 Jun 2026 16:02:18 GMT

VAlue proposition

A major drawback of Orthogonal Frequency Division Multiplexing (OFDM) is its high peak-to-average power ratio (PAPR), which causes nonlinear distortion, lower power efficiency and performance losses. An additional concern is fragility under hostile jamming attacks. By implementing a modified OFDM method the system effectively transforms the time domain signal into a frequency domain signal, adjusts the gain, and converts it back to the time domain while preserving the original bitstream. This approach addresses the PAPR issue by reducing the power amplification required for transmission, thereby minimizing nonlinear distortion, power inefficiency, and out-of-band frequency dispersion. Additionally, the system enhances resilience against jamming attacks by employing advanced signal processing techniques, ensuring reliable high-speed transmission. This technology is particularly beneficial for resource-constrained IoT networks, where power efficiency and robustness are critical factors for successful implementation.

Description of Technology

The technology described is an innovative communication system utilizing an Inverse Fast Fourier Transform (IFFT) -Relocated OFDM (IR-OFDM) approach, which effectively addresses the high peak-to-average power ratio (PAPR) and fragility issues commonly associated with traditional OFDM systems. By relocating the IFFT module from the transmitter to the receiver, the IR-OFDM system eliminates the PAPR barrier while maintaining the same spectral efficiency. Furthermore, the system incorporates a securely mechanism to enhance resilience against hostile jamming attacks, particularly disguised jamming where the interference is correlated with the authorized signal. This is achieved by integrating Advanced Encryption Standard (AES) into the IR-OFDM transceiver design, which introduces random or dynamic constellation, ensuring reliable performance under such adversarial conditions. The IR-OFDM and SP-IR-OFDM systems have potential for use in next-generation secure and energy-efficient high-speed communications, particularly in resource-constrained IoT networks.

Benefits

High spectral efficiency
Simple receiver design
Resilience to multipath propagation
Reduced peak-to-average power ratio
Enhanced security:
Compatibility with IoT networks
Lower computational complexity
Bandwidth efficiency

Applications

Wireless communication networks
Optical communication systems
Underwater communication systems
Iot networks
Satellite communication
Radar systems

IP Status

US Patent12,309.019

LICENSING RIGHTS AVAILABLE

Full licensing rights available

INVENTORs: Tongtong Li and Jian Ren

Tech ID: TEC2022-0018

For more information about this technology,
contact Jon Debling PhD at deblingj@msu.edu or 1(517)884-1653

Methods for Low-Overhead, Fault-Tolerant CNOT Operations.

techtransfer@buffalo.edu — Mon, 29 Jun 2026 16:02:09 GMT

Methods for Low-Overhead, Fault-Tolerant CNOT Operations between two Non-Nearest Neighboring Logical Qubits

Background:

The term Noisy Intermediate-Scale Quantum (NISQ) has been used to describe the current state of quantum computing technology because (1) qubits are highly error prone; and (2) the number of qubits in a single (monolithic) Quantum Processing Unit (QPU) are limited. In order to build a quantum computer useful for practical scientific and engineering applications, we need to improve the fault-tolerance performance and increase the number of qubits. This has led to an increased interest in quantum error correction (QEC) and distributed quantum computing (DQC).

Technology Overview:

This University at Buffalo technology addresses current limitations in quantum computing resulting from the high rate of error and limited qubit composition of current quantum computing syst0ems. Specifically, this method can act as a backbone for performing fault-tolerant logical operations in a Distributed Quantum computing (DQC) system using only one pair of entangled physical qubits during CNOT operation.

https://buffalo.technologypublisher.com/files/sites/7761_in-part_image.jpg

vchalup, https://stock.adobe.com/uk/234578887, stock.adobe.com

Advantages:

This method can be applied to any CSS code, which makes it more versatile than the specific variants.
The method has constant space overhead as it only requires one ancilla Bell Pair.
On top of requiring only one Bell pair established or routed, the proposed method will reduce the total number of physical CNOT operations on the physical qubits of A and B, respectively, from N down to possibly a very small number n < N

Application:

Quantum Computing
Lab (material testing/characterization.)

Intellectual Property Summary:

United States Provisional Patent Application 64/054,327 filed April 30, 2026.

Stage of Development:

TRL 3

Licensing Status:

Available for licensing or collaboration.

Additively Manufactured MEMS Lorentz Force Magnetometer Device/ Devices Array and 3D printed Magnetostrictive MEMS Magnetometer Device/ Devices Array

cabrigo@usf.edu — Mon, 29 Jun 2026 15:33:29 GMT

Advantages

Cuts production costs and speeds up prototyping compared to traditional semiconductor manufacturing methods.
Unlocks complex three-dimensional sensor shapes that conventional fabrication techniques simply cannot produce.
Delivers precise, customizable magnetic sensing that measures flux density from any direction.
Enables smaller, simpler packaging by avoiding the bulky optics used in competing sensors.

Summary

Magnetic field sensors quietly power everything from phone compasses to automotive steering systems, with growing demand from medical diagnostics, robotics, and quantum computing. Yet manufacturers face a costly bottleneck: traditional semiconductor fabrication is slow, expensive, and locks devices into flat, two-dimensional designs. The market urgently needs sensors that are miniaturized, sensitive, affordable, and adaptable to space constrained, three-dimensional systems, a need current methods simply cannot satisfy.

This technology combines 3D printing with piezoelectric MEMS resonators, replacing the bulky optical readouts found in other 3D printed sensors with compact piezoelectric transduction. The result is a sensor that is easier to miniaturize and package while remaining simple and affordable to manufacture. Because additive manufacturing builds layered structures directly, it enables complex, non-planar geometries that conventional fabrication cannot achieve, offering a scalable, customizable alternative to existing Hall effect or SQUID sensors for demanding automotive, medical, and quantum applications.

Simulated mode shapes and resonant frequencies of the proposed devices with Si and traditional method.

Desired Partnerships

License
Sponsored Research
Co-Development

Additively Manufactured/ 3D Printed Resonant MEMS Device and a Resonant MEMS Array

cabrigo@usf.edu — Mon, 29 Jun 2026 15:27:49 GMT

Advantages

Enables complex 3D device shapes impossible through traditional flat manufacturing methods
Supports diverse materials for flexible integration across many substrate types
Cuts development time and costs by removing expensive fabrication tooling needs
Boosts performance and signal clarity through smarter resonator design features

Summary

As electronics evolve toward wearable and flexible formats, MEMS resonators face a critical design bottleneck. Conventional manufacturing locks devices into flat, two-dimensional shapes using costly tooling and a narrow range of silicon-based materials. This rigidity blocks the three-dimensional architectures, exotic materials, and conformal designs that next generation applications urgently require.

This technology applies additive manufacturing to build resonant MEMS devices layer by layer, combining electrodes, piezoelectric material, and structural elements on rigid or flexible substrates. By moving beyond subtractive fabrication, it unlocks complex 3D geometries, broader material choices, and faster prototyping. Built in features like modified anchors and reflectors boost performance, while easy array printing strengthens signal quality, offering real advantages for telecommunications, defense, and healthcare partners.

Desired Partnerships

License
Sponsored Research
Co-Development

SIGMA DELTA QUANTIZATION FOR IMAGES

heguangm@msu.edu — Sat, 27 Jun 2026 21:51:41 GMT

VAlue proposition

The value proposition of this technology lies in its innovative approach to image quantization using Sigma Delta quantization. By segmenting pixel values into columns and quantizing each column as a whole using Sigma Delta modulation, the technique minimizes accumulated quantization error, thereby enhancing the reconstruction quality of the image. Furthermore, the 2D generalization of Sigma Delta modulation allows for a more comprehensive quantization process. This technology not only improves the efficiency of digital signal processing by reducing the information conversion rate but also ensures the reconstruction quality is maintained. Its practicality is further enhanced by the ability to operate in an online manner, making it suitable for real-time applications. The simplicity of the mathematical operations involved, particularly the preference for addition and subtraction over multiplication and division, makes it feasible for implementation in analog hardware.

Description of Technology

This technology introduces a novel method for image quantization through the application of Sigma Delta quantization. By segmenting pixel values into columns and quantizing each column as a whole using Sigma Delta modulation, the technique effectively minimizes accumulated quantization error, thereby enhancing the overall reconstruction quality of the image. The 2D generalization of Sigma Delta modulation further refines this process, allowing for a more comprehensive quantization approach. This method not only improves the efficiency of digital signal processing by reducing the information conversion rate but also ensures that the reconstruction quality is maintained. Its practicality is further enhanced by the ability to operate in an online manner, making it suitable for real-time applications. The simplicity of the mathematical operations involved, particularly the preference for addition and subtraction over multiplication and division, makes it feasible for implementation in analog hardware.

Benefits

Enhanced Image Quality
Efficient Digital Signal Processing
Real-Time Application Suitability
Simplicity in Implementation
Analog Hardware Compatibility

Applications

Digital image processing
Audio signal processing
Video compression
Medical imaging
Optical character recognition
Wireless communication
Sensor systems

IP Status

US Patent11,818,479

LICENSING RIGHTS AVAILABLE

Full licensing rights available

INVENTORs: Rongrong Wang and He Lyu

Tech ID: TEC2020-0142

For more information about this technology,
contact Jon Debling PhD at deblingj@msu.edu or 1(517)884-1653

clampFISH 2.0: Fast, Cost-Effective RNA Detection Using Potent Fluorescent Probes

lbricha@upenn.edu — Fri, 26 Jun 2026 20:32:49 GMT

Molecular diagnostic using clamping fluorescent probes to amplify RNA detection signal of single-cell assay
Problem:
The molecular diagnostics market is expected to reach $13 billion by 2024, including cancer detection, blood screening, histology assays, tests for transplant compatibility, and inherited and infectious diseases (The World Market for Molecular Diagnostics, 8th Edition, 2019.) RNA detection is a type of molecular diagnosis that is estimated to make up $800 million by 2024, but it is limited by low signal.
Solution:
To improve RNA detection, clampFISH physically “clamps” the traditional probes onto the target RNA using common, efficient click-chemistry. The clamped probe attracts many fluorescent amplifier probes, increasing the signal. Its high cost hinders this first clampFISH version. The new clampFISH 2.0 obtains 400-fold signal amplification for detecting RNA while also reducing cost, increasing specificity, and shortening the protocol.
Technology:
clampFISH 2.0 utilizes redesigned, smaller clamping probes to bind target RNA. The new design is modular, requiring only one custom chemical modification. These improvements reduce the cost of probe production significantly. The new design also improves selectivity, shortening washing steps and overall protocol time.

Microscopy images showing a sharper readout with an gene expression example; here the example gene is AXL, which encodes the cell surface receptor tyrosine kinase. Using a faster protocol, clampFISH 2.0 provides a clearer picture (right panel) versus a common alternative for RNA detection (left panel- labelled smFISH for single molecule fluorescence in situ hybridization).
Advantages:

Provides 400X amplification of signal for detecting RNA molecules on a cell-by-cell basis as compared to traditional fluorescent probes
Shorter nucleotide probes (90nt versus 140-142nt in first clampFISH version) reduce protocol cost and increase signal specificity
Protocol time is significantly reduced compared to the first clampFISH version
RNA and DNA detection can be overlaid

Stage of Development:

Bench Prototype

Intellectual Property:

US Patent Pending

Reference Media:

Dardani, I et al.; Nat Methods 2022 Oct 24; 19: 1403
Rouhanifard et al. Nat Biotechnol, 2018 Nov 12; 37: 84 Correction Filed 2019

Desired Partnerships:

License
Co-development

Docket #20-9229

LINEARIZATION TECHNIQUES FOR WIRELESS DIGITAL TRANSMITTERS

heguangm@msu.edu — Fri, 26 Jun 2026 20:19:36 GMT

VAlue proposition

There is demand for compact, power-efficient, and low-cost wireless communication solutions, particularly in mobile and wearable systems and fifth-generation (5G) cellular communications. High-density integration, low power consumption, and improved linearity are crucial for meeting the requirements of high data rates, wide bandwidth, and high spectral efficiency. The use of digital transmitters or digital power amplifiers (DPA) with an array of small unit PA cells controlled by a digital code word offers significant advantages over conventional analog transmitter architectures, including reduced power consumption, smaller form factor, and enhanced performance at various output power levels. This technology for achieving enhanced linearity in digital transmitters ensures high-quality wireless communication performance while maintaining power efficiency and compact design.

Description of Technology

This technology introduces an innovative digital transmitter architecture that leverages a digital signal processor and a switched capacitor circuit to achieve enhanced linearity and power efficiency. The switched capacitor circuit comprises a plurality of unit cells arranged in parallel, each consisting of a capacitor coupled to either a drive voltage or a reference voltage via a switch implemented by two transistors. By temporally shifting the control signals applied to the transistors, the switching resistance is minimized, resulting in improved linearity. The circuit is partitioned into two subsets of unit cells, with one subset being switched between the drive voltage and reference voltage based on a control signal, while the other subset remains unswitched. This design enables the digital transmitter to deliver high-quality wireless communication performance while maintaining a compact form factor and low power consumption, making it suitable for various applications such as mobile and wearable systems, as well as fifth-generation (5G) cellular communications.

Benefits

Enhanced Linearity
Power Efficiency
Compact Form Factor
High-Quality Wireless Communication
Versatility

Applications

Mobile and cellular communications
Wireless audio devices
Internet of things
Automotive industry
Consumer electronics

IP Status

US Patent11,424,770

LICENSING RIGHTS AVAILABLE

Full licensing rights available

INVENTORs: Sangmin Yoo and Si-Wook Yoo

Tech ID: TEC2020-0094

For more information about this technology,
contact Jon Debling PhD at deblingj@msu.edu or 1(517)884-1653

Microfluidic Intravital Window

IEA@rfsuny.org — Fri, 26 Jun 2026 19:30:43 GMT

A self-contained device that facilitates simultaneous in vivo viewing and remotely controlled fluid delivery to the target tissue.

Background:
Research has led to a new understanding of how tumor microenvironment heterogeneity presents delivery barriers that hamper the effectiveness of cancer treatments. High-resolution imaging can identify, localize, and quantify heterogeneity in the tumor microenvironment, in vivo, and reveal cell-cell interactions and mechanisms that cannot be observed using fixed tissue, i.e., tissue samples, which have been cross-linked in paraformaldehyde (PFA) and then, stained for selected antibodies to allow for imaging by microscopy. Such in vivo imaging can inform the controlled release of therapeutics to the target tissue.

Technology Overview:
This invention relates to devices for in vivo viewing of target tissue, and, more particularly, to a microfluidic intravital window which provides both high-resolution in vivo imaging over extended time periods and remotely controlled release of fluids into the target tissue, e.g., controlled release of factors into a tumor microenvironment.

The microfluidic fluid source and delivery system is self-contained and completely located within the intravital imaging window. The device includes at least one preloaded fluid reservoir, at least one fluid port in fluidic communication with both the at least one preloaded fluid reservoir and the target tissue, and at least one light activated fluid flow control device situated between the at least one preloaded fluid reservoir and at least one fluid port, to facilitate simultaneous in vivo viewing and remotely controlled fluid delivery to the target tissue.

The invention is remotely activated, dynamically controllable, efficient and versatile in application, and readily fabricated using soft lithography processes.

https://suny.technologypublisher.com/files/sites/16-04-0142.jpeg

Advantages:
•   Provides the ability to visualize, identify and manipulate specific cell types and their dynamics while they are resident in the living tissue at both the primary and various secondary sites.
•   Efficient and versatile in application. (combining multiple reagents reduces the number of total tests)
•   Information content increases more than geometrically with the number of parameters.
•   Subset identification can be combined with intracellular metabolic measurements.
•   Readily fabricated using soft lithography processes.

Intellectual Property Summary: Patented
US10117990B2 US10117990B2 - Microfluidic intravital window

Licensing Status:
This technology is available for licensing.

Thin-Film-Glass Organic Electro-Optic Modulator for Ultra-High-Speed and Energy-Efficient Optical Interconnects

JianlingL@tla.arizona.edu — Fri, 26 Jun 2026 17:51:12 GMT

This invention is a type of ultra-high-speed electro-optic modulator (>100GHz) that integrates nonlinear optical polymers with thin film waveguides to allow for high-bandwidth modulation with low drive voltage. These devices could offer a practical replacement for silicon nitride or thin-film lithium niobate modulators. Unlike conventional silicon and coherent method based on lithium niobate modulators, which depend heavily on digital signal processing (DSP), this platform can reduce DSP load through its intrinsic high-bandwidth operation. By reducing DSP-related power consumption, this technology enables higher GPU density, lower cooling requirements, and improved overall data center efficiency.

Background:
AI data centers and high-performance computing systems are increasingly constrained not by compute capability, but by power consumption and thermal limits. Current optical interconnect solutions rely on DSP-intensive architectures, which introduce significant energy overhead, heat generation, and system complexity. This technology addresses these limitations by enabling direct, high-bandwidth modulation that reduces dependence on DSP, leading to improved system efficiency and scalability.

Applications:

Data-center optical interconnects
Co-packaged optics
High-speed optical transceivers

Advantages:

Ultra-high-speed operation (>100 GHz class)
Reduced DSP dependency and lower system power
Improved thermal performance and cooling efficiency
Higher GPU density enabled within fixed power budgets
Architectural simplification of optical interconnect systems
Low operating voltage
Smaller footprint
Enables a new class of optical interconnect architectures beyond conventional silicon and lithium niobate (LoNbO₃) platforms

Interferometric Reflectance Confocal Microscope for Label-Free Imaging of Dynamic Sub-Cellular Activities

JianlingL@tla.arizona.edu — Fri, 26 Jun 2026 17:03:26 GMT

This invention describes the design of an interferometric reflectance confocal microscope that can achieve label-free imaging of dynamic sub-cellular activities through the use of intensity temporal fluctuation analysis in conjunction with a confocal microscopy approach and interference detection. The microscope can be used widely in biology laboratories and by pharmaceutical companies for basic research, drug development, and personalized medicine.

Background:
Fluorescent agents are commonly used to visualize sub cellular activities in microscopy. The staining process, however, is labor intensive and time consuming, which makes it difficult to observe live samples over extended periods. In addition, repeated staining can disrupt normal biological processes. This creates a need for imaging devices capable of visualizing dynamic sub cellular activities in organoids and other human tissues without the use of exogenous fluorescent agents.

Applications:

Biology laboratories
Pharmaceutical companies
Personalized medicine
Drug development
Microscopy

Advantages:

Visualization of sub-cellular activities
Label-free
Improved throughput, accuracy, and reproducibility of experimental observations
- Reduce the number of organoids that need to be cultured
- Test multiple drug conditions
Low-cost compared to current label-free microscope methods
Improved sensitivity in axial metabolic motion
Enables longitudinal monitoring

Mechagenic Energy System: An “Electrochemical Stomach” for Continuously Powering Robots and Aircraft

lbricha@upenn.edu — Fri, 26 Jun 2026 14:42:46 GMT

An electrochemical system for continuously powering robots through the ingestion of energy-dense organic molecules, utilizing a new electrolyte that enables the maximization of material performance. This system also provides a method for recycling and reusing the materials used in the stomach.
Problem:
The electrification of existing battery-powered systems is hampered by the significant time required for charging and recovery. Due to this inherent limitation, robots and electric vehicles have restricted operational time; overcoming these constraints requires a substantial increase in energy and power density. Conversion reaction battery systems that use lithium-sulfur (Li-S) and Li-air can meet the energy demand aspect, but are difficult to recharge or recover, making them uneconomical. For example, the mass-produced rechargeable batteries have energy densities below 250 Wh kg-1, while short-range all-electric aircraft typically require 750 to 2,000 Wh kg-1. These factors contribute to the increased cost of these vehicles, and consequently, handling the energy needs remains a significant challenge throughout their lifetime.
Solution:
An energy system composed of a converter, a catholyte, and an anode, where the catholyte and anode can be replenished, recovered, and “recharged” for re-use. The method could serve as an alternate strategy that would (a) increase energy density and (2) permit exchange of energy storage to prolong the use time.
Technology:
The inventors developed an electrochemical system that can help rapidly regain energy and power density by ingesting liquids or solids. The solution pairs redox-active organic small molecules stored in a liquid catholyte, such as dimethyl trisulfide (CH3S3CH3), with metal anodes in a refillable electrochemical cell (also referred to as a stomach). This catholyte system could provide continuous energy and meet higher energy and power density demands. To achieve a high current output of 193.5 A kgstomach-1, a current collector is designed, and the catholyte composition is altered to prompt the CH3S3CH3 transport and prevent electrode polarization. Experiments demonstrate that a 43.7 Ah electrochemical cell (stomach) with CH3S3CH3 and Li could achieve an energy density of 918.7 Wh kgstomach-1 and provide power for 23.4 hours in a 24-hour period with 5 refills of catholyte. Unlike fuels in engines and fuel cells, the catholyte and Li are recyclable with electrical input and can be reused in this system.
Advantages:

This technology can be employed in systems that require a higher energy density.
This invention could help quickly replenish energy availability in rechargeable systems.
The catholyte and Lithium utilized in this system can be recycled with electrical input and reused in the system.
The Li-specific recycling efficiency of 99.98% (lab demonstrated) is a solid advantage.
For robot and aircraft applications, the system could be cost-efficient than the existing rechargeable batteries and gasoline-based power systems.

Stage of Development:

Prototype

The figure (A) shows the illustration of a stomach-powered robot dog that ingests energy-dense organic small molecules and converts chemical energy into electricity. Figure B depicts the structure of the proposed electrochemical cell with a carbon collector, a porous polymer separator, a Li metal anode, and the case. The plot shown in Figure C is the discharge curves of the electrochemical cell using constant and pulsed current modes.
Intellectual Property:

US Patent Pending

Reference Media:

Pikul Research Group
State Key Laboratory of Molecular Engineering of Polymers, Fudan University

Desired Partnerships:

License
Co-development

Docket # 23-10332

Mobile Urban Air Temperature Shelter with Variable-Speed Ventilation for Multi-Modal Thermal Sensing on Vehicles

IEA@rfsuny.org — Fri, 26 Jun 2026 13:57:07 GMT

This invention is a compact, insulated, vehicle-mounted shelter with sensors and a variable-speed fan that accurately measures urban air temperature and moisture at human scale, syncing data with GPS to enable precise, hyperlocal urban climate mapping.

Background:
Urban meteorology is a rapidly evolving field that seeks to understand the complex interactions between built environments and atmospheric conditions, particularly at the microscale. Accurate, high-resolution measurements of air temperature and humidity are essential for applications such as urban climate research, public health assessments (e.g., heat stress analysis), and the development of smart city infrastructure. Traditional weather stations, typically designed for stationary deployment in open areas, are not well-suited for capturing the rapid spatial variability of temperature and moisture that characterizes urban landscapes. As cities continue to grow and experience more frequent extreme heat events, there is an increasing need for technologies that can provide reliable, hyperlocal environmental data, especially in densely populated or vulnerable neighborhoods. Current approaches to mobile urban climate monitoring, such as mounting sensors on vehicles, face significant limitations. Most vehicle-mounted probes lack controlled airflow, leading to inconsistent sampling that fails to accurately represent human-scale exposure scenarios. Additionally, these systems often do not integrate real-time GPS data, making it difficult to synchronize environmental measurements with specific locations or transit events (e.g., bus stops). The absence of standardized methods for hyperlocal data collection means that existing datasets are often sparse, inconsistent, or subject to errors from heat conduction, spatial averaging, and environmental contamination. Volunteer-based mobile data collection efforts, while valuable, tend to be irregular and lack the reproducibility required for scientific or policy applications. As a result, there remains a critical gap in the ability to obtain reliable, reproducible, and location-specific urban meteorological data using current mobile sensing technologies.

Technology Overview:
The described technology is a compact, vehicle-mounted shelter designed for precise urban air temperature and moisture measurement at the microscale. Measuring approximately 10x10 cm with an internal volume of less than 1 liter, the shelter is constructed from 3D-printed ABS plastic or anodized aluminum and painted white to maximize solar reflectivity. Its louvered vents, protected by mesh filters, allow for passive ventilation while shielding the sensors from rain and debris. The base is insulated with foam to prevent heat transfer from the vehicle, ensuring accurate readings. Inside, a variable-speed, battery-powered axial fan simulates three airflow scenarios—standing, walking, and bicycling—by drawing external air through the shelter at controlled rates. A fast-response thermistor and a high-accuracy moisture sensor are centrally mounted to capture real-time environmental data. The system is managed by a Raspberry Pi Zero, which integrates GPS for location tagging, records timestamped sensor data, and uploads this information to the cloud via Bluetooth or Wi-Fi. Sensor activation and ventilation modes are triggered at vehicle stops, ensuring consistent and reproducible sampling. This solution is differentiated by its ability to deliver hyperlocal, human-scale environmental data in urban settings, overcoming the limitations of both stationary weather stations and traditional mobile probes. Unlike stationary shelters, which cannot capture the rapid spatial variability of urban microclimates, or mobile sensors that suffer from heat contamination and lack airflow control, this technology uses active, variable-speed ventilation to mimic real-world human exposure scenarios. The integration of GPS and automated data logging enables precise synchronization with vehicle routes and stop locations, providing granular, reproducible datasets essential for urban climate research, health impact assessments, and smart city applications. Its compact, insulated, and robust design ensures reliable operation in challenging urban environments, establishing a new standard for high-resolution, mobile meteorological sensing.

https://suny.technologypublisher.com/files/sites/adobestock_269208204.jpeg
Photo for reference only, not a depiction of the invention.

Advantages:
•   Enables accurate, hyperlocal urban air temperature and moisture measurements with high spatial resolution.
•   Simulates human-scale airflow conditions (standing, walking, bicycling) for realistic environmental sensing.
•   Compact, insulated design minimizes heat conduction from vehicles, reducing measurement errors.
•   Integrates GPS for synchronized, location-specific data collection along vehicle routes.
•   Automated data logging and cloud synchronization facilitate real-time monitoring and analysis.
•   Protects sensors from rain and debris with louvered vents and mesh filters, ensuring durability.
•   Supports scalable deployment on public transit vehicles for comprehensive urban climate mapping.

Applications:
•   Urban heat island mapping
•   Public health heat risk assessment
•   Smart city microclimate monitoring
•   Hyperlocal weather data services
•   Optimized urban transit routing

Intellectual Property Summary:
Patent Pending

Stage of Development:
TRL 2

Licensing Status:
This technology is available for licensing.

A Low Swelling, Pressure-Free Method for Producing of Lithium Metal Anodes

lbricha@upenn.edu — Fri, 26 Jun 2026 13:50:58 GMT

A 3D gyroid polymer microlattice enables new type of lithium-metal batteries by reducing non-unifrom Li etching in lithium metal anodes.
Problem:
Lithium (Li) metal pouch cells represent the future of lithium-metal batteries due to their thinness and high capacity. But one caveat has held back these cells: significant volume increases after cycling mitigate the benefits of lithium anodes. During Li deposition, Li tends to nucleate randomly and causes the formation of voids in the electrodes. Those voids lead to nonuniform Li etching during cycling, and eventually, dramatic swelling. To suppress swelling, many studies have exerted high pressure to stabilize Li deposition, which is impractical for most applications.
Solution:
3D-printed polymer gyroid is used as a scaffold to control molecular interaction between Li, polymer, and the liquid electrolyte. This geometric, mechanical, and chemical control avoids applying high pressure to suppress swelling while maintaining the thinness of Li pouch cells.
Technology:
To achieve high-rate, swelling-free, and pressure-free Li anodes, the polymer is coated with amines, a functional group that binds to Li+ and facilitates Li+ ion transport. A small overpotential distributes the flowing metal throughout the hollow polymer, resulting in voids-free Li growth. By coating the polymer with -SO2F- groups they react with Li+ and form a protective solid electrolyte interphase (SEI) at the polymer-Li-electrolyte triple-phase. This layer of protection stabilizes Li deposition under pressure-free conditions.
Advantages:

Pressure- and swelling-free fabrication of Li metal pouch cells
A 3D polymer gyroid features a high Li volume fraction, high Li-polymer contact area, mechanical robustness, and manufacturability
Surface F- functional group helps form protecting LiF interphase
A 308 Wh kg-1/2.1 Ah Li pouch cell achieves 80.2% capacity retention over 226 cycles with less than 7% swelling
With 2.6-fold excess Li, the pouch cell can achieve 860 cycles with 80.1% retention in capacity
With 5-fold excess Li, the cell can achieve an 1180-cycle life with 74.1% retention in capacity

Stage of Development:

Concept
Proof of Concept

A. Traditional high-swelling and high-pressure Li deposition. B. The low-swelling and low-pressure Li deposition method used in the disclosure. C. Pressure-free operation of Li metal pouch cells. D. Schematic illustration of the 3D printing process to make the gyroid, and further functional group modifications.
Intellectual Property:

US Patent Pending

Reference Media:

Johnson, AC et al. J. Power Sources, 2022 Jun 1; 532: 231359.

Desired Partnerships:

License
Co-development

Docket #23-10161

Top Discharge IRG Bio-Crude Oil Production

IEA@rfsuny.org — Fri, 26 Jun 2026 13:46:16 GMT

The Top Discharge IRG Bio-Crude Oil Production technology introduces a simplified and efficient method for producing bio-crude oil by condensing oil vapors in inclined piping while maintaining elevated temperatures to prevent water condensation.

Background:
Traditional bio-crude oil production methods involve complex systems with multiple components such as bottom discharge syngas piping, quencher vessels, scrubber systems, and gas blowers. These components increase the complexity, operational difficulties, and costs associated with the process. While exploring improvements under a project funded by the U.S. Office of Naval Research, a novel approach was discovered that streamlines these processes for better efficiency and economic viability.

Technology Overview:
The Top Discharge IRG Bio-Crude Oil Production method innovates by using inclined piping to condense oil vapors while maintaining the temperature above 250°F. This temperature control is critical as it prevents the formation of water condensate, which can complicate the recovery process and degrade product quality. By doing so, the technology eliminates the need for several conventional components such as bottom discharge syngas piping, quencher vessels, scrubber systems, and gas blowers. This significantly simplifies the overall system design, reduces maintenance and operational costs, and increases reliability. The innovation builds upon and modifies existing intellectual property related to inclined rotary gasification processes but introduces a more streamlined vapor condensation technique. Its design leverages the natural thermal properties and gravity within the inclined piping system to optimize bio-crude recovery directly from gasification vapors. Overall, this technology's value proposition lies in its ability to reduce complexity while improving efficiency and cost-effectiveness in bio-crude oil production, making it a valuable advancement in sustainable fuel technologies.

https://suny.technologypublisher.com/files/sites/adobestock_881949394.jpeg
Photo for reference only, not a depiction of the invention.

Advantages:
•   Eliminates multiple complex components such as syngas piping, quenchers, scrubbers, and blowers, reducing system complexity and maintenance.
•   Maintains operational temperature above 250°F to prevent water condensation, ensuring higher quality bio-crude output.
•   Enhances efficiency by simplifying the vapor condensation process within inclined piping.
•   Lowers production costs and operational overhead through a streamlined process design.
•   Improves system reliability by reducing the number of mechanical parts subject to failure.

Applications:
•   Bio-crude oil production facilities seeking cost-effective and efficient processes.
•   Renewable energy projects focused on sustainable fuel generation via gasification.
•   Government and military research initiatives looking to optimize biofuel production technologies.
•   Industrial operations aiming to replace or enhance existing bio-crude vapor condensation systems.

Intellectual Property Summary:
Patent pending

Stage of Development:
TRL 4

Licensing Status:
Technology available for licensing

Spectrum Sharing via Collaborative RFI Cancellation for Radio Astronomy

IEA@rfsuny.org — Fri, 26 Jun 2026 13:34:59 GMT

This technology enables radio telescopes to remove interference from cellular networks by sharing and analyzing signal patterns, allowing them to filter out unwanted noise and preserve clear astronomical data without losing valuable information.

Background:
Radio astronomy is a field dedicated to observing and analyzing naturally occurring radio emissions from celestial objects, providing invaluable insights into the universe’s origins, structure, and evolution. As radio telescopes become increasingly sensitive, they are able to detect extremely faint signals from distant cosmic sources. However, the rapid expansion of terrestrial wireless communication systems—such as cellular networks, Wi-Fi, and satellite communications—has led to a dramatic increase in radio frequency interference (RFI) within the frequency bands that are also crucial for astronomical research. This growing overlap poses a significant threat to the ability of radio astronomers to collect clean, uncontaminated data, making effective RFI mitigation strategies essential for the continued advancement of astrophysical discoveries. Current approaches to RFI mitigation at radio telescopes primarily rely on local sensing and filtering techniques, such as time-frequency excision, adaptive filtering, and spatial nulling. These methods often assume that the subspaces occupied by RFI and astronomical signals are orthogonal, an assumption that breaks down in the presence of complex, time-varying interference like that generated by modern cellular networks. Furthermore, traditional techniques typically operate without direct knowledge of the RFI source characteristics, limiting their effectiveness against dynamic and spectrally diverse interference. As a result, these methods frequently lead to the loss of valuable astronomical data, reduced sensitivity, and the inadvertent removal of weak cosmic signals. The inability to adapt to rapidly changing RFI environments and the lack of collaboration between communication networks and observatories highlight the urgent need for more sophisticated, cooperative, and adaptive RFI mitigation solutions.

Technology Overview:
This technology is a collaborative method for mitigating radio frequency interference (RFI) at radio telescopes by leveraging information from cellular networks. It operates by first characterizing the RFI at the cellular base station using the Karhunen–Loeve Transform (KLT), which provides a compact and adaptive eigenspace representation of the interference. This eigenspace is then transmitted to the radio telescope, where the incoming composite signal—containing both astronomical data and RFI—is similarly decomposed. The telescope projects its eigenspace onto a subspace orthogonal to the RFI eigenspace, effectively nullifying the interference and enabling the reconstruction of a clean astronomical signal. This method is robust to time-varying RFI, does not require continuous synchronization between the base station and telescope, and is adaptable to various frequency bands and interference types. Experimental results show it can remove up to 89.04% of RFI power, significantly enhancing the quality of astronomical observations. What differentiates this technology is its collaborative spectrum sharing approach, which contrasts sharply with traditional RFI mitigation methods that rely solely on local sensing at the telescope. By characterizing RFI at its source—where the interference is strongest and least affected by propagation effects—the method provides a more accurate and dynamic representation of the interference. This enables more effective cancellation, especially in challenging environments like the sub-6 GHz bands heavily used by commercial networks. The use of KLT/SSA allows the system to adapt to the non-stationary nature of modern RFI, outperforming static Fourier-based techniques. Additionally, the approach minimizes the loss of astronomical data by reducing the need for data excision, which is a common but blunt tool in traditional RFI mitigation. The method's adaptability, high RFI removal rate, and potential for integration with existing infrastructure make it a significant advancement in protecting the integrity of radio astronomical observations amidst growing spectrum congestion.

https://suny.technologypublisher.com/files/sites/adobestock_1774145818.jpeg
Photo for reference only, not a depiction of the invention.

Advantages:
•   Significantly reduces radio frequency interference (RFI) from cellular networks, improving the quality of astronomical observations by removing up to 89.04% of RFI power.
•   Enables dynamic adaptation to time-varying RFI conditions across different frequency bands and RFI types.
•   Utilizes collaborative spectrum sharing between cellular base stations and radio telescopes for more accurate RFI characterization and cancellation.
•   Does not require continuous synchronization between the RFI source and the telescope, enhancing operational flexibility.
•   Preserves the integrity of astronomical signals by projecting out RFI components without excessive data excision or sensitivity loss.
•   Employs advanced eigenspace decomposition techniques (Karhunen–Loeve Transform) for precise RFI modeling and cancellation.
•   Offers superior performance compared to traditional telescope-based RFI mitigation methods by characterizing interference at its origin.
•   Supports potential integration with existing cellular and satellite communication infrastructures, promoting cooperative spectrum management.

Applications:
•   Radio astronomy data quality enhancement
•   Collaborative spectrum sharing management
•   Cellular network interference mitigation
•   Satellite communication RFI suppression

Stage of Development:
TRL 3

Licensing Status:
This technology is available for licensing.

Engineered TFPI-2 KD1 Peptide Therapeutics for Control of Excessive Bleeding (UCLA Case Nos. 2019-981, 2012-611, 2006-064)

marketing@tdg.ucla.edu — Fri, 26 Jun 2026 00:13:08 GMT

UCLA researchers in the School of Medicine have developed engineered peptide therapeutics based on the tissue factor pathway inhibitor-2 (TFPI-2) Kunitz domain 1 (KD1), which can serve as potent inhibitors of fibrinolysis to control excessive bleeding.

BACKGROUND: Excessive bleeding remains a major unmet need in hematology, surgery, trauma care, and other settings in which fibrin clots are broken down too quickly. Fibrinolysis, the physiological degradation of fibrin clots, is primarily driven by plasmin. Uncontrolled plasmin activity can cause hyperfibrinolysis and clinically significant blood loss during cardiac bypass surgery, trauma, thrombolytic therapy, organ transplantation, and orthopedic surgery. Existing antifibrinolytic agents lack high affinity and specificity, necessitating high doses which can lead to side effects and organ toxicity. The use of aprotinin, a potent plasmin inhibitor, has been limited by safety concerns associated with off-target protease inhibition of kallikrein. Therefore, there is a strong need for more potent, selective, and well-tolerated antifibrinolytic agents to stabilize clots and reduce blood loss.

INNOVATION: UCLA researchers led by Dr. Paul Bajaj have engineered related mutant peptides from human TFPI-2 KD1, a naturally derived plasmin inhibitor. They have conducted biochemical and clotting studies to show that selected variants improve plasmin inhibition and clot strength relative to wild type KD1. Furthermore, in vivo studies in mice indicate that these engineered peptides reduce blood loss and outperform wild type KD1 and current antifibrinolytic. Notably, these engineered peptides are strong inhibitors of plasmin while showing minimal inhibition of kallikrein, a potentially important selectivity advantage. In vivo studies also showed no renal toxicity or immune reactions in response to these peptides. Thus, this technology can serve as a targeted hematology therapeutic for safe and effective management of excessive bleeding.

POTENTIAL APPLICATIONS:

Prevention and treatment of excessive bleeding associated with surgery
Management of hyperfibrinolysis
Trauma/hemorrhage control
Clot stabilization in high risk procedures (e.g. transplantation)

ADVANTAGES:

Potent antifibrinolytic activity and reduced blood loss
High plasmin selectivity with minimal kallikrein inhibition
No renal toxicity or detectable immune response

DEVELOPMENT-TO-DATE: The engineered peptides have been validated by biochemical, clotting, and in vivo mouse studies.

Related Papers (from the inventors only):

Bajaj MS, Ogueli GI, Kumar Y, Vadivel K, Lawson G, Shanker S, Schmidt AE, Bajaj SP. Engineering kunitz domain 1 (KD1) of human tissue factor pathway inhibitor-2 to selectively inhibit fibrinolysis: properties of KD1-L17R variant. J Biol Chem. 2011 Feb 11;286(6):4329-40. doi: 10.1074/jbc.M110.191163. Epub 2010 Nov 29. PMID: 21115497; PMCID: PMC3039392.
Kumar Y, Vadivel K, Schmidt AE, Ogueli GI, Ponnuraj SM, Rannulu N, Loo JA, Bajaj MS, Bajaj SP. Decoy plasminogen receptor containing a selective Kunitz-inhibitory domain. Biochemistry. 2014 Jan 28;53(3):505-17. doi: 10.1021/bi401584b. Epub 2014 Jan 13. PMID: 24383758; PMCID: PMC3985851.
Vadivel K, Kumar Y, Ogueli GI, Ponnuraj SM, Wongkongkathep P, Loo JA, Bajaj MS, Bajaj SP. S2'-subsite variations between human and mouse enzymes (plasmin, factor XIa, kallikrein) elucidate inhibition differences by tissue factor pathway inhibitor -2 domain1-wild-type, Leu17Arg-mutant and aprotinin. J Thromb Haemost. 2016 Dec;14(12):2509-2523. doi: 10.1111/jth.13538. Epub 2016 Nov 19. PMID: 27797450; PMCID: PMC5504414.
Vadivel, K., Zaiss, A. K., Kumar, Y., Fabian, F. M., Ismail, A. E. A., Arbing, M. A., Buchholz, W. G., Velander, W. H., & Bajaj, S. P. (2020). Enhanced Antifibrinolytic Efficacy of a Plasmin-Specific Kunitz-Inhibitor (60-Residue Y11T/L17R with C-Terminal IEK) of Human Tissue Factor Pathway Inhibitor Type-2 Domain1. Journal of Clinical Medicine, 9(11), 3684. https://doi.org/10.3390/jcm9113684

Keywords: Tissue factor pathway inhibitor-2, TFPI-2, Kunitz domain 1, KD1, mutant polypeptide, plasmin inhibitor, protease inhibitor, antifibrinolytic, fibrin clot, blood loss, thrombolytic therapy, organ transplantation, orthopedic surgery, anti-cancer, hemorrhage, hyperfibrinolysis, engineered peptide, trauma

An Implantable Device for Restoring Muscle Function in Nerve or Muscle Impairment

lbricha@upenn.edu — Thu, 25 Jun 2026 20:53:47 GMT

A neuroprosthetic implant that uses existing nerve or muscle signals to replace damaged muscle and restores movement
Problem:
While prosthetics often replace entire limbs, smaller nerve or muscle injuries are common, severely impact daily life, and have limited treatment options. Facial paralysis is one example, where nerve damage causes muscle weakness, asymmetry, and loss of expression. Restoring a natural smile requires two complex surgeries using donor nerves and muscles, leading to scars, long recovery, and inconsistent outcomes. Alternative nerve stimulation approaches are also limited, as target muscles may be damaged or missing and electrodes can be unstable. There is a clear need for a more reliable, less invasive solution that restores muscle function without relying on damaged anatomy.
Solution:
The inventors developed an off-the-shelf neuroprosthetic implant that replaces damaged muscle and restores function without relying on weakened or missing facial structures. Only one operation is needed for this device. During implantation, the surgeon measures the needed dimensions, accesses the opposite-side facial nerve and muscles, and implants the electrode, graft, and battery to enable controlled, functional movement.
Technology:
The inventors developed a neuroprosthetic implant consisting of several components: a sensor or electrode, a power source, and a multi-stable graft. Starting from the patient thinking about a motor function, the signal travels from the brain to the sensor, which then communicates the signal to the power source, a biocompatible battery, after adequate processing. The power source will then transmit an electrical current to the reactive portion of the implanted graft. The graft is constructed of FDA-approved biocompatible materials capable of multiple stable configurations. Upon activation, the graft will then contract or relax via power source signal.
Advantages:

Obviates the need for a complex, multi-stage surgical procedure and other donor sites
Lowered risk of unintended injury to important facial structures by avoiding dissection of facial blood vessels
Holds potential to solve any singular nerve/muscle group injury in the body with known dimensions and adequate power

Stage of Development:

Concept

Schematic of the Invented Device for its Primary Application in Restoring Facial Movement
Intellectual Property:

Provisional Filed

Reference Media:

Sung Robotics Lab

Desired Partnerships:

License
Co-development

Docket #22-9777

Improved CD-4 Mimetic Compounds HIV Treatment

lbricha@upenn.edu — Thu, 25 Jun 2026 20:14:31 GMT

Indoline core CD-4 mimetics are a HIV treatment that trick the virus into entering a vulnerable “open” conformation, allowing antibody-dependent cellular toxicity.
Problem:
HIV impacts 38 million individuals worldwide, many of whom are receiving treatment. A barrier to successful treatment is viral rebound after cessation of antiviral therapy. To infect a cell, HIV normally fuses with the target cell by using a trimeric surface glycoprotein to bind to the CD4 receptor on T cells. This binding interaction requires the surface glycoprotein to enter an “open state.” HIV hides from the body’s immune system by traveling in a protected “closed” conformation, only transitioning to a vulnerable “open” state when it is ready to infect a cell. These features make it difficult to stop viral entry, recognize the virus before it binds to a cell, and clear infected cells.
Solution:
Promoting this open state outside of when the virus is entering the cell allows for immune system recognition and clearance of the virus. CD-4 mimetics bind to viral surface glycoprotein, mimicking the interaction between the virus and the endogenous CD-4 receptor. This triggers a premature and stable conformational change to the open state. In this state, the virus can’t interact with a real CD-4 receptor, and thus can’t enter cells. Further, the stabilized open conformation makes the virus vulnerable to detection from the immune system. Infected cells can then be recognized by antibodies and removed by the immune system.
Technology:
Guided by molecular-resolution structures of a CD-4 mimetic bound to the HIV viral particle, the inventors developed improved indoline scaffold CD-4 mimetics that exploit a hydrophobic cavity in HIV glycoprotein. These improvements better stabilize the open conformation of the HIV glycoprotein, leading to a 30-fold increase in inhibition of viral entry, improved host antibody recognition, and improved removal of infected cells.
Advantages:

30-fold improvement in viral entry inhibition
Readily synthesized from commercially available materials
Low micromolar IC50 for difficult to neutralize HIV strains
7-fold enhancement in antibody recognition
15% increase in antibody-mediated cellular toxicity

Stage of Development:

Target Identified
Preclinical Discovery

Normalized IC50 values against viral infection for indoline CD-4 mimetic compounds compared to previous lead compound, BNM-III-170.
Intellectual Property:

US Patent Pending

Reference Media:

Fritschi, C et al., Proc Natl Acad Sci, 2023 Mar 28; 120(13): e2222073120
Chaplain, C et al., ACS Med Chem Lett, 2022 Dec 6; 14(1): 51
Jette, C et al., Nat Commun, 2021 Mar 29; 12(1): 1950

Desired Partnerships:

License
Co-development

Docket: 22-10040

Magnet powder and sintered magnet of strontium and barium M-type modified hexagonal ferrite

IEA@rfsuny.org — Thu, 25 Jun 2026 19:19:18 GMT

This technology uses a special magnet powder made from strontium and barium hexagonal ferrite to create strong, durable sintered magnets.

Background:
The field of permanent magnets plays a crucial role in a wide range of modern technologies, including electric motors, generators, loudspeakers, and various electronic devices. Among the different types of permanent magnets, ferrite magnets are particularly valued for their low cost, chemical stability, and resistance to demagnetization. Strontium and barium hexaferrites, which possess a hexagonal crystal structure, are commonly used due to their favorable magnetic properties and abundance of raw materials. As industries increasingly demand more efficient and compact devices, there is a growing need for magnets that offer higher magnetic performance without significantly increasing costs or compromising stability. Despite their widespread use, conventional strontium and barium hexaferrite magnets face several limitations. Traditional manufacturing processes often result in magnets with suboptimal magnetic properties, such as lower coercivity and remanence, which restrict their effectiveness in high-performance applications. Additionally, the particle size and morphology of the magnet powder can be difficult to control, leading to inconsistencies in the final product. Current approaches also struggle to enhance the intrinsic magnetic properties of these materials without resorting to expensive or complex processing techniques. These challenges highlight the need for improved methods to produce ferrite magnets with superior and more consistent magnetic characteristics.

Technology Overview:
This technology centers on the development of magnet powder and sintered magnets composed of strontium and barium m-type modified hexagonal ferrite. The material is engineered by precisely adjusting the ratios of strontium and barium within the hexagonal ferrite crystal structure, resulting in a magnet powder that can be compacted and sintered into robust, high-performance magnets. These magnets exhibit strong magnetic properties, excellent thermal stability, and resistance to demagnetization, making them suitable for a wide range of industrial and consumer applications. The process allows for the production of magnets in various shapes and sizes, offering flexibility for integration into electric motors, sensors, loudspeakers, and other electronic devices. What sets this technology apart is its innovative modification of the traditional hexagonal ferrite composition. By incorporating both strontium and barium in controlled proportions, the resulting magnetic material achieves a superior balance of magnetic strength and durability compared to conventional ferrite magnets. This dual-element approach enhances the intrinsic coercivity and remanence, leading to improved performance in demanding environments. Additionally, the sintering process ensures a dense, uniform microstructure, which further boosts the magnet's reliability and longevity. The combination of material science advancements and manufacturing precision makes this solution highly differentiated in the field of permanent magnets.

https://suny.technologypublisher.com/files/sites/adobestock_290850858.jpeg
Photo for reference only, not a depiction of the invention.

Advantages:
•   Enhanced magnetic properties due to m-type modified hexagonal ferrite composition
•   Improved performance in magnetic applications using strontium and barium ferrites
•   Potential for high thermal stability and corrosion resistance
•   Cost-effective production through powder and sintering processes
•   Versatility for use in various electronic and industrial devices

Applications:
•   Electric motor manufacturing
•   Loudspeaker production
•   Magnetic sensor devices
•   Magnetic separation equipment
•   Magnetic data storage

Intellectual Property Summary:
Know-how based

Stage of Development:
TRL 2

Licensing Status:
This technology is available for licensing.

IMPLEMENTING FLEXIBLE, CONTENT-ADAPTIVE DEEP LEARNING NEURAL NETWORKS

heguangm@msu.edu — Thu, 25 Jun 2026 18:29:52 GMT

VAlue proposition

The value of this technology lies in its ability to create input-adaptive neural networks that dynamically adjust their computational complexity based on the characteristics of input data, such as video frames, while maintaining high accuracy. This adaptability allows for significant reductions in computational demand and power consumption, making it particularly suitable for resource-constrained mobile devices like smartphones, drones, and augmented reality headsets. By employing an early exit mechanism that is automatically determined, the system can efficiently process video data with minimal latency and energy usage, addressing the critical need for high-throughput, low-latency, and low-energy on-device video stream analytics. This technology not only enhances the efficiency of deep neural networks in mobile applications but also provides a scalable solution that minimizes memory footprint and computational overhead, thereby enabling a wide range of continuous mobile vision applications in real-time scenarios.

Description of Technology

The technology involves the development and implementation of Deep Neural Networks (DNNs) with flexible size and dynamic early exit strategies, specifically tailored for processing video data in mobile devices. This system employs an input-adaptive neural network that adjusts computational demand based on context characteristics such as computational resource availability, power resource availability, user settings, or characteristics of the input data units. The neural network architecture includes an early exit mechanism, which is determined through an automated process, allowing for reduced computational demand and power consumption while maintaining accuracy. The system can be applied to various tasks, including video processing, where it processes input data units (e.g., image frames) and outputs results, adjusting computational and energy requirements based on resource demand indications such as frame rate or real-time computational resource availability. Additionally, the technology provides methods for generating input-adaptive DNNs by assessing filter importance, determining early exit architectures, and optimizing accuracy-resource tradeoffs for specific devices. Furthermore, it outlines a system for modifying existing neural networks by adding early exit branches and determining confidence thresholds for early exits, enhancing the adaptability and efficiency of neural network processing in diverse applications.

Benefits

Energy Efficiency
Reduced Latency
Scalability
High Accuracy
Resource Optimization
Continuous Processing

Applications

Real-time video surveillance
Autonomous vehicles
Augmented reality and virtual reality
Smartphones and mobile devices
Healthcare monitoring
Gaming

IP Status

US Patent12,346,818

LICENSING RIGHTS AVAILABLE

Full licensing rights available

INVENTORs: Mi Zhang, Biyi Fang and Xiao Zeng

Tech ID: TEC2020-0001

For more information about this technology,
contact Jon Debling PhD at deblingj@msu.edu or 1(517)884-1653

MICROSCALE GAS BREAKDOWN DEVICE AND PROCESS

heguangm@msu.edu — Thu, 25 Jun 2026 18:03:03 GMT

VAlue proposition

The microscale gas breakdown device that includes a cathode, an anode, and an engineered surface structure (e.g. protrusion) on the electrode is proposed. The breakdown characteristics of the device can be adjusted with flexibility by engineered surface morphology. By employing the engineered surface on the electrode, the breakdown characteristics transit from long-gap behavior at low pressure to short-gap behavior at high pressure, keeping the breakdown voltage relatively constant for a wide range of pressure or gap distance. The engineered electrode can be used to design gas breakdown devices with controlled breakdown voltage across many orders in pressure and gap size, which may be used in microscale device applications, including micro-switches and microchips.

Description of Technology

The microscale gas breakdown device is designed to control and manipulate electrical discharges at small scale. It consists of two primary surfaces that are separated by a defined gap distance. This gap is where the electrical breakdown occurs, allowing for the generation of controlled plasma or other phenomena dependent on the pressure conditions (high or low) surrounding the device. The device operates by applying either a current or a voltage across the two surfaces using a dedicated current source or voltage source. This electrical input triggers a discharge. The length and characteristics of the discharge paths are influenced by the perturbation's dimensions, which are based on the expected pressure environment surrounding the device. This design ensures that the device can adapt its discharge behavior dynamically, making it highly versatile for various applications. Its ability to operate efficiently under varying pressure conditions, combined with its low power consumption and high precision, makes it an attractive solution. The design provides a highly efficient, adaptable, and versatile solution for managing electrical discharges in a microscale environment with ability to dynamically respond to pressure variations.

Benefits

High Precision and Control
Adaptability to Pressure Conditions
Low Power Consumption
Compact Size

Applications

Micro-electro-mechanical systems (MEMS)
Micro-switches
Microchip devices.

IP Status

US Patent11,371,960

LICENSING RIGHTS AVAILABLE

Full licensing rights available

INVENTORs: Yangyang Fu, Peng Zhang and John Verboncoeur

Tech ID: TEC2019-0006

For more information about this technology,
contact Jon Debling PhD at deblingj@msu.edu or 1(517)884-1653

LINEARITY ENHANCEMENT FOR DIGITAL WIRELESS TRANSMITTERS AND DIGITAL POWER AMPLIFIERS

heguangm@msu.edu — Thu, 25 Jun 2026 17:19:41 GMT

VAlue proposition

Digital transmitters and digital power amplifiers are an active area with the advance of CMOS technology. Energy-efficient transmitters are critical for many applications that employ MIMO, multiband, and multi-standard transceivers because of multiple transmitters being adopted in a single chip or system. A very linear transmitter with wide bandwidth is also desired as is reduced chip area and high data throughput. This technology offers a comprehensive solution for enhancing the performance of digital wireless transmitters. It addresses key challenges such as energy efficiency, linearity, and bandwidth, making it a valuable advancement for the development of next-generation wireless communication systems.

Description of Technology

The technology described is a method for correcting phase distortion in a digital wireless transmitter. This technique involves several steps. The process begins with the reception of a Radio Frequency (RF) signal in the analog domain. This is achieved through a digital-to-RF modulator, which converts digital data into an RF signal. The received RF signal is then amplitude modulated in accordance with a digital input code. The next step involves introducing a delay in the signal path traversed by the RF signal. The duration of this delay is determined by the value of the digital input code. The purpose of this delay is to substantially cancel out the phase distortion that may have been introduced by the digital wireless transmitter. The primary application of this technology is in digital wireless communication systems where phase distortion can affect the quality and reliability of the transmitted data. By correcting this distortion, the system can maintain higher data integrity and improve overall performance. The specific areas of applicability may vary depending on the exact implementation and design of the digital wireless transmitter system.

Benefits

Energy Efficiency
Improved Linearity
Wide Bandwidth
Reduced Chip Area
High Data Throughput

Applications

5g networks
Internet of things
Wireless communication systems
Wireless audio and video streaming
Wireless sensor networks
Medical devices
Automotive industry
Broadcasting equipment
Wireless sensor networks for agriculture
Consumer electronics
Space communication

IP Status

US Patent10,666,306

LICENSING RIGHTS AVAILABLE

Full licensing rights available

INVENTORs: Sangmin Yoo and Si-Wook Yoo

Tech ID: TEC2019-0040

For more information about this technology,
contact Jon Debling PhD at deblingj@msu.edu or 1(517)884-1653

Self-Assembling Nanolattices with Superior Tensile Strength That are Scalable and Free of Cracks

lbricha@upenn.edu — Thu, 25 Jun 2026 16:49:12 GMT

Elimination of cracks in self-assembly using a wet template and positively charged particles produces relatively large-area nanolattices with enhanced tensile strength.
Problem:
Nanolattice fabrication is currently dominated by 3D-printing that employs 2-photon polymerization. However, structures made in this fashion feature imperfections which lead to tensile strength that is well below theoretical limits. Additionally, the 2-photon method can take upwards of 16 times longer than methods using self-assembly. Current self-assembly methods suffer from concentrated areas of stress from cracks which result from a dry template producing evaporation step.
Solution:
To ameliorate the problems of a dry-template creation step, and avoid producing face centered cubic lattices from spherical nanoparticles with intrinsic cracking, the inventors use glycerol and dispersion polymerization of positively charged particles to ensure simultaneously that nanolattices are crack-free and that electro-deposition of metal occurred.
Technology:
To produce nanolattices, a conductive material is placed in colloidal suspension and then heated. The subsequent evaporation is energetically favorable to the formation of face-centered cubic lattices, which act as a template. A nanolattice is then impressed onto the opal via electrodeposition of nickel, and the underlying template is removed (see Figure). The inventors avoid the negative tendency of nickel to concentrate in template cracks, by including glycerol during evaporation. Through the addition of this low vapor pressure alcohol and positively charged particles to the electrodeposition medium, nickel can adhere seamlessly onto the template.
Advantages:

Order of magnitude improvements in ultimate tensile strength over other porous metals
Smaller volumes with higher load capability
Self-assembly method improves scalability and speed over 3D-printing options
20,000x increase in crack-free area compared to other methods of self-assembly
Significant potential to improve nanolattice application in high-power density batteries, heat and mass exchangers plus selective infiltration membranes

Stage of Development:

Proof of Concept

Conventional method of self-assembly (a and c) compared to glycerol facilitated self-assembly of template and positive particle-based metal electrodeposition to produce nanolattices that are crack-free (d and e).
Intellectual Property:

US Patent Pending

Reference Media:

Jiang, Z et al., Langmuir 2020 Jul 7; 3 (26): 7315

Desired Partnerships:

License
Co-development

Docket #21-9735

Small-Molecule Therapeutic for Stabilizing HIV-1 Envelope Proteins to Increase Immune Response

lbricha@upenn.edu — Thu, 25 Jun 2026 15:30:24 GMT

Small-molecule inhibitor that prolongs exposure of HIV-1 to broadly neutralizing antibodies to suppress viral entry and infection
Problem:
The human immunodeficiency virus (HIV-1) infects human cells through binding of its envelope proteins to surface-expressed CD4 and CCR5 receptors. Broadly neutralizing antibodies can recognize the native, functional shape of envelope to suppress infection. However, interactions between the envelope proteins and CD4 receptors trigger conformational changes of envelope. The host immune system cannot recognize these conformations of HIV-1 envelope and fail to suppress viral entry and infection.
Solution:
The therapeutic is a chemical analogue of a small-molecule viral entry inhibitor, BMS-806. These chemicals stabilize the HIV-1 envelope protein in its native, functional shape, and thus, blocking any conformational changes. This allows broadly neutralizing antibodies to bind and neutralize the HIV-1 spike proteins. The inhibitory effect of the therapeutic is reversible upon removal.
Technology:
Inhibition of HIV infection is based on a benzoyl ring. The therapeutics were modified with either azide or diazirine groups at the opposite side of BMS-806 to stabilize the interaction between the benzoyl group and HIV-1 envelope protein. The therapeutic also depends on an intact binding cavity within HIV-1 envelope proteins, suggesting they inhibit viral infection by blocking this site.
Advantages:

Long-acting and stabilize HIV-1 envelope protein in its native, functional shape for at least 21 days after a single application
Maintain or enhance binding of most broadly neutralizing antibodies to native, functional shape of HIV-1 envelope protein

Stage of Development:

Preclinical Discovery

The percent of drug-bound HIV-1 Env protein as a function of time. Existing viral entry inhibitors, BMS-806 and BMS-529 are compared to analogues . Two of the six analogues remain bound to Env protein after three weeks. In addition, nearly all analogues perform better than BMS-806 or BMS-529.
Intellectual Property:

US Patent Pending
EP Patent Pending

Reference Media:

Zou, S et al. J. Virol., 2020 May 4, 94(10): e00148-20

Desired Partnerships:

License
Co-development

Docket #20-9154

ROOM TEMPERATURE QUANTUM PROCESSOR BASED ON ON-CHIP ARRAYS OF SINGLE-ION QUDITS ENABLED BY MATERIALS SCIENCE AND ENGINEERING

IEA@rfsuny.org — Thu, 25 Jun 2026 14:37:34 GMT

This technology is a scalable, on-chip quantum sensor using single-erbium ion qubits in silicon-based nanopillars, enabling high-performance, room-temperature quantum sensing and communication, compatible with standard semiconductor manufacturing and suitable for aerospace and photonic integrated circuits.

Background:
Quantum sensing and quantum photonics represent rapidly advancing fields with the potential to revolutionize precision measurement, secure communication, and information processing. At the heart of these technologies are quantum devices that leverage the unique properties of quantum bits (qubits), such as superposition and entanglement, to achieve sensitivities and functionalities far beyond classical systems. There is a growing demand for quantum sensors that are not only highly sensitive and accurate but also practical for real-world deployment, particularly in sectors like aerospace, telecommunications, and defense. The ability to integrate quantum devices with photonic integrated circuits (PICs) and to fabricate them using scalable, foundry-compatible processes is essential for transitioning quantum technologies from laboratory demonstrations to widespread commercial and industrial use. Despite significant progress, current approaches to quantum sensing and photonic integration face substantial limitations. Most quantum devices require operation at extremely low temperatures—often below 3 K—and in high-vacuum environments, making them bulky, energy-intensive, and unsuitable for many practical applications, especially where size, weight, and power (SWaP) constraints are critical. Additionally, existing single-photon emitters (SPEs) at telecom wavelengths, which are vital for quantum networking and distributed sensing, are not robust or scalable enough for integration into large-scale systems. These challenges hinder the deployment of quantum sensors in real-world environments and limit their compatibility with standard semiconductor manufacturing processes, thereby restricting their potential impact across industries.

Technology Overview:
This technology is an on-chip quantum sensor platform that leverages arrays of individually addressable single-erbium ion qubits embedded within silicon-based hollow nanopillars. Utilizing advanced nanofabrication and materials engineering, the platform is fully compatible with standard semiconductor foundry processes, enabling scalable and cost-effective production. These quantum devices exhibit exceptional performance at room temperature, unattainable with current technologies. The quantum devices exhibit coherent operation in the telecom C-band with record-long optical quantum coherence exceeding 500 μs. Furthermore, another unique quantum functionality of the device is its ability to enable fast, high-contrast (>96%) coherent optical readout in the visible range (e.g., 518 nm) without an optical cavity. Together, these results establish a comprehensive telecom- and CMOS-compatible engineering strategy, enabled by materials science and engineering, that overcomes the ubiquitous challenge of maintaining quantum coherence under ambient conditions, enabling operation at temperatures more than 900-times higher than those required by current cryogenic quantum systems. Additionally, its design allows seamless integration with photonic integrated circuits (PICs). The platform is engineered to minimize size, weight, and power consumption, making it particularly well-suited for aerospace and other applications where these factors are critical. What differentiates this technology is its unique combination of scalability, operational practicality, and high performance. Unlike traditional quantum devices that require extreme cryogenic conditions and are often incompatible with large-scale manufacturing, this solution supports room-temperature operation and is fabricated using industry-standard processes. The use of single-erbium ion qubits in silicon-based hollow nanopillars not only enables telecom-wavelength operation—crucial for quantum networking and distributed sensing—but also achieves high readout fidelity and narrow optical linewidths. This makes the platform a plug-and-play solution for real-world deployment, overcoming longstanding barriers to the adoption of quantum sensors in demanding environments such as aerospace. Its compatibility with photonic integrated circuits further positions it as a foundational technology for the next generation of quantum communication and sensing networks. Furthermore, the devices pave the way for advanced telecom QIS technologies that could potentially extend the range of practical applications in quantum sensing and imaging for biomedical applications, and in quantum sensing and reference systems (clock synchronization, distributed computation) for a future Quantum Internet of Things.

https://suny.technologypublisher.com/files/sites/adobestock_1486219683.jpeg
Photo for reference only, not a depiction of the invention.

Advantages:
•   Enables room temperature operation of quantum sensors, eliminating the need for extreme cryogenic cooling.
•   Compatible with foundry-based semiconductor fabrication processes for scalable, large-scale production.
•   Demonstrates record-long optical coherence times in the telecom C-band, exceeding 500 μs at ambient conditions, a performance previously limited to vacuum conditions at temperatures over 900 times lower.
•   Provides high readout contrast (>96%) and narrow single-ion optical linewidths (<90 MHz) in the telecom C-band for precise quantum sensing and communication.
•   Integrates seamlessly with photonic integrated circuits, facilitating compact and efficient quantum photonic devices.
•   Reduces size, weight, and power (SWaP) requirements, making it ideal for aerospace and other demanding applications.
•   Supports operation at ambient conditions (e.g., room temperature operation), enhancing practicality and robustness in real-world environments.
•   Offers plug-and-play, individually addressable quantum sensor arrays for versatile deployment in quantum networking and distributed sensing.

Applications:
•   Quantum networking for secure communications
•   Distributed quantum sensing arrays
•   Aerospace navigation and sensing systems
•   Photonic integrated circuit quantum sensors
•   Telecom-band quantum key distribution

Intellectual Property Summary:
Patent pending.

Stage of Development:
Inquire for more informaion

Licensing Status:
This technology is available for licensing.

Single Use Minimally Invasive Orthopedic Bone Biopsy and Graft Introduction Tray

IEA@rfsuny.org — Thu, 25 Jun 2026 14:19:59 GMT

The Single Use Minimally Invasive Orthopedic Bone Biopsy and Graft Introduction Tool Tray is an all-inclusive, innovative tool tray designed to improve the efficiency and effectiveness of orthopedic macro biopsies through a safe, secure, controlled minimally invasive approach even through normal intact cortical bone.

Background:
Orthopedic surgeons performing bone biopsies have faced challenges with existing tools that are often outdated, reusable, and inefficient compared to those used in other medical specialties like interventional radiology to obtain much smaller samples and hematology/oncology for bone marrow aspiration. These limitations have driven the need for a new solution that streamlines the biopsy process while maintaining minimally invasive techniques, ultimately improving patient safety, outcomes and surgical efficiency.

Technology Overview:
This technology introduces a single-use tray specifically designed for orthopedic bone biopsy and graft introduction. Unlike current reusable instruments, the tray is fully self-contained, providing all necessary components in one sterile package, which reduces preparation time and potential contamination risks. A key novel feature is the inclusion of a bur guide, which ensures precise control during the biopsy procedure, facilitating the controlled milling of a longitudinal channel in the bone rather than creation of a simple drill hole with less access to a sizable sample as is used in current interventional radiology bone biopsies, enhancing accuracy and safety. The design focuses on simplifying the biopsy process by integrating tools thoughtfully optimized for macro biopsies performed by orthopedic surgeons. This innovation eliminates the need to adapt tools from other disciplines, offering a purpose-built solution that addresses both clinical and operational needs in orthopedic surgery.

https://suny.technologypublisher.com/files/sites/adobestock_498816675.jpeg
Photo for reference only, not a depiction of the invention.

Advantages:
•   Single-use design reduces infection risk and eliminates the need for sterilization.
•   All-inclusive tray streamlines surgical preparation and reduces instrument clutter.
•   Incorporation of a bur guide ensures enhanced precision during biopsy procedures.
•   Capability of biopsy portal stabilization with pins ensures efficient access to the created biopsy channel.
•   Includes tools for bone graft introduction after biopsy.
•   Specifically designed for orthopedic surgeons, improving procedural effectiveness over generic tools.
•   Minimally invasive approach promotes faster patient recovery and less postoperative discomfort.
•   Avoids case delays due to contaminated reusable equipment.
•   Eliminates need for resharpening and maintenance of reusable equipment
•   Eliminates inefficiencies associated with outdated reusable instruments.

Applications:
•   Orthopedic surgical procedures requiring bone biopsy sampling.
•   Introduction of bone graft materials during minimally invasive orthopedic treatments.
•   Clinical environments prioritizing sterile, single-use surgical kits to reduce infection risks.
•   Hospitals and surgical centers seeking specialized instrumentation tailored to orthopedic macro biopsies.

Intellectual Property Summary:
Patent Pending

Stage of Development:
TRL 2

Licensing Status:
This technology is available for licensing.

Infrared-Based Drying Method in Lithium-Ion Battery Electrodes

ip@skysonginnovations.com — Wed, 24 Jun 2026 19:23:43 GMT

Invention Description

Conventional electrode drying processes act as a massive bottleneck in lithium-ion battery (LIB) manufacturing. Current processes typically rely on large convection ovens followed by vacuum post-drying to remove residual solvent and moisture. These steps are energy-intensive, require a large factory footprint, and add complexity to electrode production. In addition, conventional drying provides limited control over the polymeric binder structure, even though binder crystallinity, phase behavior, and distribution strongly influence electrode adhesion, internal resistance, and long-term electrochemical stability.

Researchers at Arizona State University have developed an infrared-based drying process to improve the manufacturing process of cathodes for lithium-ion batteries. In this approach, IR drying rapidly heats the coated cathode surface in a controlled manner, enabling effective solvent and moisture removal while simplifying the conventional drying sequence that typically requires an additional vacuum post-drying step. Beyond process simplification, the IR drying condition can also regulate the crystallinity and phase behavior of polymeric binders, which are critical to electrode adhesion, internal resistance, and long-term electrochemical stability. Among tested methods, IR-Post drying demonstrated superior mechanical adhesion, efficient solvent removal, and lower internal resistance, which lead to enhanced rate performance and stable capacity retention over extensive cycling.

This infrared drying technology contributes to superior electrode mechanical integrity, efficiency and electrochemical performance in battery cells.

Potential Applications

Lithium-ion battery manufacturers seeking energy-efficient production methods
Electric vehicle battery producers targeting higher performance and durability
Energy storage system providers focused on cost-effective and scalable electrode fabrication
Battery research and development facilities optimizing cathode materials
Roll-to-roll electrode manufacturing lines requiring compact and high-throughput drying technologies

Benefits and Advantages

Significant reduction in energy consumption during drying
Shorter processing times with direct electrode surface heating
Improved mechanical adhesion and structural stability of cathodes
Enhanced electrochemical performance with lower internal resistance
Optimized binder crystallinity contributing to mechanical and electrochemical improvements

For more information about this opportunity, please see

Nguyen et al – ACS Appl. Energy Mater.- 2026

“Alex Takes Care of a Lake”: A Children’s book about Aquatic Invasive Species

christopher.perkins@rutgers.edu — Wed, 24 Jun 2026 18:02:44 GMT

Invention Summary:

"Alex Takes Care of a Lake" is a creative work designed, written and illustrated by Joanne Diglio, a local children’s author, illustrator and teacher, and Pat Rector, a county Environmental and Resource Management Agent.

Synopsis

One day a curious boy named Alex is kayaking on a lake when he comes across a water chestnut, an aquatic invasive species. After learning about the harm aquatic invasive species cause nature, he decides to help take care of the environment.

Details

This creative work is one that educates children about the harm aquatic invasive species cause nature, how they are detrimental to a well-balanced ecosystem and how they can be managed.

This is the story of a curious boy who goes kayaking with his dad and asks questions, teaches about aquatic invasive species, ecology of lakes and the environment. The curious boy learns what he can do to help and takes action.

Beautiful watercolor illustrations are included with the text.

Advantages:

“Alex Takes Care of a Lake” is an easy to understand, fun way to teach children about ecology, lakes and specifically about aquatic invasive species and the harm they cause nature.

The book also covers plants such as water chestnuts and water lettuce; lake systems, zones and ecosystems and New Jersey Lake Hopatcong State Park.

Intellectual Property & Development Status:

Available through license or distribution agreement

License This Technology

Research & Education License
$0.00

Customizable implantable testicular prosthetics

IEA@rfsuny.org — Wed, 24 Jun 2026 17:20:22 GMT

This innovation introduces a customizable implantable testicular prosthesis with an adjustable size, enabling precise fit and improved surgical outcomes.

Background:
Existing testicular prosthetics are typically available as either pre-sized balloon-type implants or solid silicone models. These fixed-size options often present challenges during surgery, as incorrect sizing can lead to discomfort, poor aesthetic results, or the need for additional procedures. Manual trimming of prosthetics is time-consuming and may not always yield an optimal shape or fit. This highlights a clear need for a prosthetic option that offers intraoperative size adjustment without compromising structural integrity.

Technology Overview:
The newly developed technology is a “nested” solid silicone testicular prosthesis featuring multiple peelable layers, allowing surgeons to adjust the implant size directly during the operation. Unlike traditional balloons filled with fluid or solid prostheses fixed in size, this design provides a modular approach whereby layers of silicone can be selectively removed to tailor the prosthesis to the patient's anatomical needs. This innovation streamlines surgical procedures by eliminating the guesswork associated with sizing and minimizes the need for manual modifications, which can be inconsistent and labor-intensive. The prosthesis maintains the durability and natural feel of solid silicone while introducing a novel method for dimensional customization. Surgeons can achieve a better cosmetic match and enhanced patient comfort, leading to higher satisfaction rates. Additionally, by reducing operative time and complexity, this technology has the potential to improve overall clinical efficiency and reduce healthcare costs.

https://suny.technologypublisher.com/files/sites/adobestock_150608240.jpeg
Photo for reference only, not a depiction of the invention.

Advantages:
•   Adjustable size via peelable silicone layers allows precise fit tailored during surgery.
•   Retains the natural texture and durability of solid silicone materials.
•   Streamlines surgical workflow by eliminating manual trimming and reduces operative time.
•   Enhances patient comfort and cosmetic outcomes with a customizable approach.
•   Reduces need for repeat surgeries related to size mismatches or poor fit.

Applications:
•   Implantation during orchiectomy procedures for patients requiring testicular prosthetics.
•   Use in reconstructive surgeries following trauma, cancer, or congenital absence of testicles.
•   Clinical settings where customized and efficient implant fitting is critical.
•   Potential adoption in urology and plastic surgery practices focusing on genitourinary restoration.

Intellectual Property Summary:
Patent Pending

Stage of Development:
TRL 4

Licensing Status:
This technology is available for licensing.

Build a Case-A Cold Case Simulator

IEA@rfsuny.org — Wed, 24 Jun 2026 17:05:35 GMT

"Build a Case - A Cold Case Simulator" is an innovative card game designed to realistically replicate the investigative process of solving cold cases in a safe and educational environment.

Background:
Investigating cold cases can be an engaging educational tool, but the graphic and sensitive nature of real cases often limits their use in classroom or training settings. There is a need for a less explicit yet immersive method to expose learners to the complexities of cold case investigations without encountering inappropriate content or necessitating access to confidential material. This gap inspired the development of a simulation game that balances educational value with accessibility and replayability.

Technology Overview:
The Build a Case simulator is a card-based game that mimics the step-by-step process of working on unsolved criminal cases. Players navigate through various investigative elements represented by cards, piecing together information and clues to progress toward solving the case. This approach enables immersive learning through active participation rather than passive observation. The game is carefully designed to avoid the use of real or graphic case details, making it suitable for educational institutions and group discussions. Its key novelty lies in combining the complexity of a cold case investigation with a simplified, engaging format that encourages critical thinking and collaboration. The system offers high replay value due to varied scenarios and card combinations, supporting both entertainment and facilitated learning experiences. Moreover, as the invention does not rely on third-party intellectual property, it provides a flexible platform for educators and facilitators to implement without legal concerns. Educators and facilitators can also use the cards as discussion points to link to well-known or current cases to deepen understanding of the complexities involved in these cases, as appropriate for the audience.

https://suny.technologypublisher.com/files/sites/adobestock_440720303.jpeg
Photo for reference only, not a depiction of the invention.

Advantages:
•   Safe and appropriate alternative to real cold case materials, preserving sensitivity while promoting engagement.
•   Highly replayable with multiple scenarios and outcomes, keeping users continually challenged.
•   Encourages active learning, critical thinking, and teamwork through interactive gameplay.
•   No reliance on existing intellectual property, enabling ease of distribution and customization.
•   Suitable for both entertainment and structured educational settings, increasing versatility.

Applications:
•   Use in schools and universities as a pedagogical tool for criminal justice, forensic science, and psychology courses.
•   Facilitated group discussions or workshops centered on problem-solving and investigative methods.
•   Informal entertainment for players interested in mystery and detective-style games.
•   Professional training environments seeking a non-sensitive method for practicing investigative teamwork and reasoning skills.

Intellectual Property Summary:
Patent Pending

Stage of Development:
TRL 3

Licensing Status:
This technology is available for licensing.