Search Results - nucleic+acids

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Antisense Oligonucleotides to Prevent Genetic Mis-Splicing for ALS/FTD Therapeutics
SHORT DESCRIPTION Antisense oligonucleotides (ASOs) that correct TDP‑43–dependent mis‑splicing of KCNQ2 thereby reducing neuronal hyperexcitability in ALS/FTD and related TDP‑43 proteinopathies. INVENTORS Evangelos Kiskinis* Northwestern University Feinberg School of Medicine, Department of Neurology Jonathan...
Published: 5/12/2026   |   Updated: 5/7/2026   |   Inventor(s):  
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, FTD - Frontotemporal Dementia, Neurodegenerative disease, Neurologic disease, Neurology, Nucleic Acids, Rare diseases, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
UNAFold® - Software suite for simulating and predictig nucleic acid folding, hybridization, and melting behavior
RPI ID: 2017-042 Innovation Summary: UNAFold® is a comprehensive software suite designed to simulate and predict nucleic acid folding, hybridization, and melting behavior using experimentally derived free energy parameters. It models secondary structures of single-stranded DNA or RNA, either individually or in pairs, under customizable temperature...
Published: 4/27/2026   |   Updated: 12/22/2025   |   Inventor(s): Nicholas Markham, Michael Zuker
Keywords(s): Bioinformatics, Biotechnology, Design, Diagnostics, discovery tool, DNA, healthcare, Human healthcare, modeling and simulation, molecular beacon, Molecular Biology, Molecular diagnostics, Nucleic acids, PCR primer, pharmaceutical, RNA, Software
Category(s): Biotechnology and the Life Sciences
Targeting the IFITM1/OVOL1 Axis for Treating Corneal Wounds
NU 2024-159 INVENTORS Han Peng* Robert Lavker SHORT DESCRIPTION This invention addresses corneal wound healing by providing methods and compositions to target the IFITM1/OVOL1 axis to modulate limbal epithelial stem cells (LESCs) and early transit amplifying cells (eTAs). BACKGROUND Maintaining corneal transparency and vision depends on...
Published: 5/11/2026   |   Updated: 11/10/2025   |   Inventor(s):  
Keywords(s): Gene therapy, Nucleic Acids, Ophthalmic disease, RNA - Ribonucleic Acid, Therapeutics
Category(s): Life Sciences > Therapeutics
ASOs targeted towards mis-spliced UNC13A
NU2022-200 INVENTORS Wanhao Chi Jonathan Watts Evangelos Kiskinis* BACKGROUND Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative that leads to 1 in 500 deaths in adults. There is no cure to stop or reverse ALS, thus there is a need to better understand its pathobiology and develop effective therapeutics. Northwestern...
Published: 4/13/2026   |   Updated: 10/17/2024   |   Inventor(s):  
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, FTD - Frontotemporal Dementia, Neurodegenerative disease, Neurology, Nucleic Acids, Rare diseases, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
2023-021 A Ferrobotic Swarm Technology for Accessible, Adaptable, and Automated Testing
Summary: UCLA Researchers in the Department of Electrical and Computer Engineering have developed an automated, algorithm-driven nucleic acid amplification test (NAAT) method that is easy to manufacture, distribute, and yields accurate results with reduced demand of testing reagents. Background: Major epidemics over the last two decades have emerged...
Published: 8/21/2025   |   Updated: 1/25/2023   |   Inventor(s): Dino Di Carlo, Sam Emaminejad, Haisong Lin, Wenzhuo Yu, Kiarash AmirMozafariSabet
Keywords(s): Algorithm, algorithm-based testing, automated testing, Automation, Cell Counting/Imaging, COVID-19, Ferrofluid, ferrorobotics, high throughput testing, Nanotechnology, nucleic acid amplification test (NAAT), Nucleic Acid Platform Systems, Nucleic Acids, polymerase chain reaction (PCR), pooling, Software & Algorithms, viral testing
Category(s): Software & Algorithms, Life Science Research Tools, Life Science Research Tools > Research Methods, Electrical > Electronics & Semiconductors, Diagnostic Markers, Life Science Research Tools > Cell Counting And Imaging, Platforms > Diagnostic Platform Technologies
2018-438 A DNA CONSTRUCT FOR TARGETING THERAPEUTIC MOLECULES TO DISEASED TISSUE BY IMMUNE CELLS
INTRODUCTION:UCLA researchers in the Departments of Integrative Biology & Physiology and Pathology & Laboratory Medicine have developed a novel construct for targeting therapeutic biological molecules specifically to diseased tissue, using immune cells as a delivery system. BACKGROUND:Drug delivery is the process of administering a pharmaceutical...
Published: 7/17/2025   |   Updated: 12/6/2021   |   Inventor(s):  
Keywords(s): Drug Delivery, Nucleic Acid Platform Systems, Nucleic Acids, Therapeutics & Vaccines
Category(s): Platforms > Drug Delivery > Nucleic Acid Platform Systems, Platforms > Drug Delivery > Nucleic Acids
2019-863 METHODS CONCERNING ONGOING TREATMENT FOR CANCER
UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have developed a novel biomarker detection method for circulating blood cell-free RNA. BACKGROUND: Approximately 39% of men and women will be diagnosed with cancer at some point during their lifetimes. Circulating tumor cell-free DNA (cfDNA) is being increasingly used...
Published: 7/31/2025   |   Updated: 11/4/2020   |   Inventor(s): Matteo Pellegrini, Eri Srivatsan
Keywords(s): Diagnostic Markers & Platforms, Life Science Research Tools, Nucleic Acid Platform Systems, Nucleic Acids, Oncology
Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Diagnostic Markers, Platforms > Drug Delivery > Nucleic Acids
SHARPR-MPRA (Systematic High-Resolution Activation and Repression Profiling with Reporter-Tiling Massively Parallel Reporter Assay) - UCLA Case No. 2017-224
SHARPR-MPRA (Systematic High-Resolution Activation And Repression Profiling With Reporter-Tiling Massively Parallel Reporter Assay)SUMMARYUCLA researchers in the Department of Biological Chemistry have developed a method to screen hundreds to thousands of genes to identify their regulatory functions.BACKGROUNDGenetic reporter assays are used to uncover...
Published: 7/17/2025   |   Updated: 9/6/2019   |   Inventor(s): Jason Ernst, Manolis Kellis
Keywords(s): Life Science Research Tools, Nucleic Acid Platform Systems, Nucleic Acids, Research Methods
Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools, Platforms > Drug Delivery > Nucleic Acids, Platforms > Drug Delivery > Nucleic Acid Platform Systems
Scalable Lipid Bilayer Microfluidics for High-Throughput Gene Editing (UCLA Case No. 2018-437)
Scalable Lipid Bilayer Microfluidics for High-Throughput Gene EditingSUMMARYResearchers led by Paul Weiss from the Department of Chemistry and Pediatrics at UCLA have created a new microfluidic device for high-throughput gene editing of cells.BACKGROUNDGene editing has many potential applications, allowing for the modification of immune cells to target...
Published: 7/17/2025   |   Updated: 8/28/2019   |   Inventor(s): Jason Belling, Paul Weiss, Steven Jonas, Joshua Jackman, Nam-Joon Cho
Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, General Device Coatings, Life Science Research Tools, Medical Devices and Materials, Microfluidics And Mem's, Nucleic Acids, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Medical Devices > Coatings, Platforms > Drug Delivery, Therapeutics, Therapeutics > Gene Therapy And Editing, Platforms > Drug Delivery > Nucleic Acids
Improvement To Retroviral Vectors Containing The Human Ubiquitin C Promoter
SummaryUCLA researchers in the Department of Molecular Biology have developed a lentiviral vector, “pCCLc-roUBC”, containing the cellular promoter from the human ubiquitin C gene (UBC), to improve transgene expression in retroviral vectors.BackgroundGene delivery into human cells is a promising way to correct or protect against genetic alterations...
Published: 2/19/2026   |   Updated: 8/28/2019   |   Inventor(s): Donald Kohn
Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Nucleic Acid Platform Systems, Nucleic Acids, Therapeutics & Vaccines
Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics, Therapeutics > Gene Therapy And Editing, Platforms > Drug Delivery > Nucleic Acids
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