Search Results - brain+cancer

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Incomplete Autophagy Induction for the Treatment of Cancer

SHORT DESCRIPTION This incomplete autophagy inducer triggers caspase-mediated apoptosis in cancer cells by inducing incomplete autophagy, leading to tumor reduction and improved survival. INVENTORS INVENTORS Maciej Lesniak* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery Jawad...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Brain cancer, Breast cancer, Cancer/Oncology, Lung cancer, Melanoma, Repurposed Drugs, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Inhibitors of MNK Kinase for Targeted Cancer and CNS Therapeutics

NU 2015-098 (NU 2015-098, NU 2018-036, NU 2025-036) INVENTORS Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)* SHORT DESCRIPTION MNK kinase inhibitors that reduce cancer cell viability and proliferation and penetrates the brain for potential treatment of glioblastoma and CNS disorders. BACKGROUND Leukemia and brain...

Published: 5/13/2026 | Updated: 4/29/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, AML - Acute myeloid leukemia, ASD - Autism Spectrum Disorder, Bladder cancer, Brain cancer, Breast cancer, Cancer/Oncology, CNS - Central Nervous System, Colon cancer, Lung cancer, Neurodegenerative disease, Pancreatic cancer, Prostate cancer, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment

SHORT DESCRIPTION Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma. INVENTORS Amy Heimberger* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery * Principal Investigator NU Tech ID: NU 2025-212 IP...

Published: 5/7/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools

Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy

NU 2025-160 INVENTORS Jason Miska* Feinberg School of Medicine, Department of Neurological Surgery Peng Zhang* Feinberg School of Medicine, Department of Neurological Surgery SHORT DESCRIPTION Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM. BACKGROUND Glioblastoma...

Published: 4/16/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): Adjunct therapy, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Therapeutics

Category(s): Life Sciences > Therapeutics

SEC61 Complex as a Novel Therapeutic Target to Enhance Immunotherapy Response in Glioblastoma

NU 2023-011 INVENTORS Irina Balyasnikova* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery Joseph Duffy SHORT DESCRIPTION A targeted therapeutic approach that inhibits the SEC61 complex to enhance responses to immunotherapy in glioblastoma. BACKGROUND Glioblastoma (GBM) is the most aggressive primary...

Published: 4/14/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): Brain cancer, Cancer/Oncology, Immunotherapy, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Bi-specific Lipid Nanoparticles for Boosting Antitumor Immunity in Glioblastoma

SHORT DESCRIPTION A bispecific lipid nanoparticle that bridges tumor-associated myeloid cells (TAMCs) and glioma cells by dual checkpoint blockade and simultaneously reprograms TAMCs into antitumor effectors via targeted delivery of a STING agonist. INVENTORS Maciej Lesniak* Northwestern University Feinberg School of Medicine,...

Published: 4/30/2026 | Updated: 4/14/2026 | Inventor(s):

Keywords(s): Brain cancer, Cancer/Oncology, Drug delivery, Immunotherapy, Nanoparticle, Nanotechnology, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Targeting EGFR Co-Amplified Long-Noncoding RNA for Glioblastoma Treatment

NU 2025-335 INVENTORS Shi-Yuan Cheng* Xiaozhou Yu Bo Hu Runxin Wu Xiao Song SHORT DESCRIPTION This invention provides compositions and methods for inhibiting ELDR and HELDR, two long non-coding RNAs (lncRNAs) that are frequently co-amplified in glioblastoma (GBM) with the epidermal growth factor receptor (EGFR) gene, and which drive tumorigenesis...

Published: 3/30/2026 | Updated: 3/30/2026 | Inventor(s):

Keywords(s): Brain cancer, Cancer Treatment, Cancer/Oncology, Therapeutics

Category(s): Life Sciences > Therapeutics

Covalent ATG4B Inhibitors for Treatment of Cancer

NU 2025-186 INVENTORS Karl Scheidt* Weinberg College of Arts and Sciences, Department of Chemistry Claire Trudeau Shiyuan Cheng SHORT DESCRIPTION The invention introduces a novel class of peptidyl covalent reversible ketoamide inhibitors designed to target the cysteine protease ATG4B. BACKGROUND Glioblastoma (GBM) is an aggressive...

Published: 5/13/2026 | Updated: 10/28/2025 | Inventor(s):

Keywords(s): Autophagy, Brain cancer, Cancer/Oncology, GBM - Glioblastoma, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Bioelectric Neuromodulation Methods for Hematopoiesis Regulation During Chemotherapy (Case No. 2020-382)

Summary: UCLA researchers in the Department of Bioengineering have developed an electrical neuromodulation method to accelerate recovery from deleterious chemotherapy side effects to improve patient outcome. Background: Chemotherapy works by targeting and killing fast-growing cancer cells using anti-cancer drugs. However, because these drugs lack...

Published: 4/29/2026 | Updated: 8/21/2025 | Inventor(s): Wentai Liu

Keywords(s): algorithmic cancer detection, Bladder Cancer, blood cancers, Brain cancer, Breast Cancer, Cancer, cancer antigen, cancer detection, Cancer Immunotherapy, cancer inhibition, cancer metabolism, Cancer stem cells, cancer target, castration resistant prostate cancer, Chemotherapy, head and neck cancer, lympathic cancers, lymphatic cancer, Mesenchymal Stem Cell Derived Cancer Cells, Neuromodulation, non-small cell lung cancer, Orthotopic cancer models, Pancreatic cancer, prostate cancer, small cell cancer, small cell lung cancer, small cell prostate cancer

Category(s): Medical Devices, Medical Devices > Neural Stimulation, Chemical, Electrical, Therapeutics, Therapeutics > Oncology

Anti-CD73 Monoclonal Antibody for Enhanced Cancer Immunotherapy

NU 2020-207 INVENTORS Bin Zhang* Siqi Chen Jie Fan SHORT DESCRIPTION This invention comprises novel anti-CD73 monoclonal antibody compositions that recognize and inhibit mouse and human CD73. BACKGROUND CD73, an ecto-enzyme associated with adenosine metabolism, is an emerging immune checkpoint that promotes tumor progression...

Published: 5/13/2026 | Updated: 1/30/2025 | Inventor(s):

Keywords(s): Brain cancer, Breast cancer, Cancer/Oncology, Colon cancer, Gastric cancer, Immunotherapy, Lung cancer, Ovarian cancer, Pancreatic cancer, Therapeutics

Category(s): Life Sciences > Therapeutics

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