Search Results - repurposed+drugs

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Incomplete Autophagy Induction for the Treatment of Cancer
SHORT DESCRIPTION This incomplete autophagy inducer triggers caspase-mediated apoptosis in cancer cells by inducing incomplete autophagy, leading to tumor reduction and improved survival. INVENTORS INVENTORS Maciej Lesniak* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery Jawad...
Published: 5/7/2026   |   Updated: 5/7/2026   |   Inventor(s):  
Keywords(s): Brain cancer, Breast cancer, Cancer/Oncology, Lung cancer, Melanoma, Repurposed Drugs, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Dual-Action Inhibition Strategy for KRAS and LKB1 Mutant NSCLC
NU 2023-113 INVENTORS Lillian Eichner (Feinberg School of Medicine, Department of Biochemistry and Molecular Genetics)* Reuben Shaw (Salk Institute) SHORT DESCRIPTION A dual drug combination to target KRAS and LKB1 mutant non–small cell lung cancer that results in superior efficacy by enhancing T cell recruitment and reducing tumor burden. BACKGROUND Lung...
Published: 4/29/2026   |   Updated: 4/29/2026   |   Inventor(s): Reuben Shaw
Keywords(s): Cancer/Oncology, Lung cancer, Repurposed Drugs, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma. INVENTORS Amy Heimberger* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery * Principal Investigator NU Tech ID: NU 2025-212 IP...
Published: 5/7/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
Use of HCV NS3/4A Protease Inhibitors as Therapeutics for COVID-19
RPI ID: 2021-001-401 Innovation Summary: A therapeutic composition combines multiple protein inhibitors to target SARS-CoV-2 replication pathways. The method leverages synergistic interactions between inhibitors to enhance antiviral efficacy. It includes formulations for systemic and localized delivery, and supports adaptation to emerging variants....
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Khushboo Bafna, Robert Krug, Aldolfo Garcia-Sastre, Kris White, Gaetano Montelione
Keywords(s): COVID19, COVID-19 antivirals, Hepatitis C viral protease inhibitors, Repurposed Drugs
Category(s): Biotechnology and the Life Sciences
Targeting IL-6 pathway to treat high risk myelodysplastic syndromes
NU 2022-093 INVENTORS Peng Ji* Kehan Ren Yang Mei SHORT DESCRIPTION A method of inhibiting progression of high-risk myelodysplastic syndrome (MDS) or low blast count acute myeloid leukemia (AML) using an inhibitor of IL6 signaling. BACKGROUND Approximately 20,000 people in the US are diagnosed with myelodysplastic syndrome (MDS) each year....
Published: 2/17/2026   |   Updated: 2/17/2026   |   Inventor(s):  
Keywords(s): AML - Acute myeloid leukemia, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
Targeted Therapy for Glioblastoma via Purine Metabolism Modulation
NU 2019-086 INVENTORS Atique Ahmed* Cheol Park Jack Shireman SHORT DESCRIPTION This technology introduces a targeted approach for glioblastoma treatment that modulates purine biosynthesis by targeting the ARL13B-IMPDH2 interaction using repurposed FDA-approved and internationally-used drugs. BACKGROUND Glioblastoma is an incurable, aggressive...
Published: 2/6/2026   |   Updated: 6/20/2025   |   Inventor(s):  
Keywords(s): AUTM26C1, BIAUTM1, Cancer/Oncology, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
Repurposing Bumetanide to Address Cognitive Deficits in Schizophrenia
NU 2019-067 INVENTORS Herbert Y. Meltzer SHORT DESCRIPTION Repurposing bumetaide to treat cognitive deficits in schizophrenia syndrome. ABSTRACT Cognitive deficits associated with schizophrenia syndrome are the components that contribute most to a low quality of life. While current pharmacological treatments have beneficial effects on treating...
Published: 12/16/2025   |   Updated: 5/30/2023   |   Inventor(s):  
Keywords(s): Neurologic disease, Neurology, PSD - Psychotic spectrum disorder, Repurposed Drugs, Schizophrenia, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics