Search Results - cardiology+and+cardiovascular+disease

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Epigenetic Gene Editing in Cardiomyopathy to Improve Heart Function
SHORT DESCRIPTION A precision cardiac gene‑regulation platform that deletes a MYH7 enhancer to shift ventricular myosin isoform balance toward faster α‑MHC and activates upstream MYH6 enhancers to increase MYH6 expression and improve contractility, creating a dual toolkit for disease‑modifying therapy in cardiomyopathy and heart failure. INVENTORS Elizabeth...
Published: 5/13/2026   |   Updated: 5/12/2026   |   Inventor(s):  
Keywords(s): Cardiology and Cardiovascular disease, Cardiomyopathy, Gene therapy, Regenerative medicine, Therapeutics
Category(s): Life Sciences > Therapeutics
Targeted Nanofiber Therapy for Atherosclerosis – Enhanced Plaque Regression via Precise Drug Delivery
SHORT DESCRIPTION Nanofiber-based drug delivery system that targets atherosclerotic plaque and delivers a therapeutic agent locally to induce plaque regression for management of cardiovascular disease. INVENTORS Samuel Stupp* Weinberg College of Arts and Sciences, Department of Chemistry * Principal Investigator NU...
Published: 4/30/2026   |   Updated: 4/30/2026   |   Inventor(s):  
Keywords(s): Cardiology and Cardiovascular disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction
SHORT DESCRIPTION Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs. INVENTORS Youyang Zhao* Ann & Robert H Lurie Children's Hospital of Chicago * Principal Investigator NU...
Published: 5/8/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease
Category(s): Life Sciences > Therapeutics
Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2016-137, NU 2018-176, NU 2019-179, NU 2023-007, NU 2024-250, NU 2025-038) INVENTORS Richard Silverman Weinberg College of Arts and Sciences, Department of Chemistry SHORT DESCRIPTION Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression...
Published: 4/30/2026   |   Updated: 4/1/2026   |   Inventor(s):  
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, AUTM26C1, BIAUTM1, Cancer/Oncology, Cardiology and Cardiovascular disease, Immunodeficiency, Immunology, Immunotherapy, Melanoma, Neurodegenerative disease, Neuroinflammation, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Retinoic Acid Agonists for Attenuation of Doxorubicin-Induced Cardiotoxicity
SHORT DESCRIPTION A method for preventing cardiotoxicity in patients undergoing anthracycline-based chemotherapy using retinoic acid receptor gamma (RARG) agonists. INVENTORS Paul W Burridge*, PhD Associate Professor, Pharmacology, Northwestern University Feinberg School of Medicine * Principal Investigator NU...
Published: 2/6/2026   |   Updated: 2/6/2026   |   Inventor(s):  
Keywords(s): Cancer Treatment, Cancer/Oncology, Cardiology and Cardiovascular disease, Chemotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Identification of Atrial Fibrillation Progression via Integrated Electrogram and Imaging Analysis
NU 2023-222 INVENTORS Markus Rottmann* SHORT DESCRIPTION This invention integrates advanced analysis of atrial fibrillation electrograms and T1/T2 imaging to identify the progression state of AF. It offers clinicians a predictive tool to tailor treatment strategies and improve patient management. BACKGROUND Atrial fibrillation shows distinct...
Published: 12/9/2025   |   Updated: 10/28/2025   |   Inventor(s):  
Keywords(s): Cardiology and Cardiovascular disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
Morphology Recurrence Analysis for the Characterization of Atrial Fibrillation Electrograms
INVENTORS Jeffrey Goldberger* David Gordon Jason Ng SHORT DESCRIPTION This technique uses modified recurrence analysis on electrogram data to identify patient-specific arrhythmia drivers. It supports precise, tailored ablation mapping for atrial fibrillation. BACKGROUND Traditional atrial fibrillation mapping struggles with dynamic, variable...
Published: 12/9/2025   |   Updated: 10/21/2025   |   Inventor(s):  
Keywords(s): Analysis, Biomedical, Cardiology and Cardiovascular disease, Computer software, Devices, Electrophysiology, Health IT, Medical device
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Automated Echocardiographic Detection of Cardiac Amyloidosis: The Septal Reflectivity Ratio
NU2023-056 INVENTORS Sanjiv Shah* Vinesh Appadurai Mayank Kansal Akhil Narang Brody Slostad James Thomas SHORT DESCRIPTION A first-of-its-kind diagnostic tool that automates the analysis of echocardiographic images to calculate the septal reflectivity ratio, enabling precise differentiation between cardiac amyloidosis subtypes. BACKGROUND Conventional...
Published: 11/6/2025   |   Updated: 6/18/2025   |   Inventor(s): Mayank Kansal
Keywords(s): Cardiology and Cardiovascular disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Transparent Arterial Layer Separation in Cardiac Angiography with Self-Supervised Deep Learning
NU 2023-092 INVENTORS Sameer Ansari* Donald Cantrell* Leon Cho Syed Hasib Akhter Faruqui Chaochao Zhou SHORT DESCRIPTION This technology provides cardiac angiography with markedly enhanced visualization of the vasculature by leveraging self-supervised deep neural network-based background subtraction algorithms. BACKGROUND Cardiac angiography relies...
Published: 11/6/2025   |   Updated: 5/12/2025   |   Inventor(s):  
Keywords(s): Cardiology and Cardiovascular disease, Image/Signal processing
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Wireless, Implantable Catheter-type Oximeter Designed for Cardiac Oxygen Saturation
LUNU 2020-226 INVENTORS John Rogers* Wei Lu Joseph Forbess Zhi-Dong Ge SHORT DESCRIPTION This technology introduces a wireless, miniaturized, implantable catheter-type oximeter designed to offer real-time monitoring of intravascular oxygen levels for post-cardiothoracic surgery care. BACKGROUND Accurate, real-time monitoring of intravascular oxygen...
Published: 11/6/2025   |   Updated: 5/7/2025   |   Inventor(s):  
Keywords(s): Biomedical, Cardiology and Cardiovascular disease, Devices, Diagnostics, Medical device, Optics, Sensors, Wireless
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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