Search Results - targeted+therapy

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Compositions and Methods for Enhanced Mitochondrial Delivery for Regenerative Therapies

SHORT DESCRIPTION A novel peptide coating process that improves mitochondrial cell uptake, preserves function, and enables targeted delivery for cardiovascular and regenerative therapies. NU Tech ID NU 2025-055 INVENTORS Bin Jiang* Northwestern University Feinberg School of Medicine, Department of Surgery (Vascular...

Published: 6/18/2026 | Updated: 6/18/2026 | Inventor(s):

Keywords(s): BIO2026, Cardiology and Cardiovascular disease, MI - Myocardial Infarction, Neurodegenerative disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease, Vascular repair

Category(s): Life Sciences > Therapeutics

Inhibitors of TRIP8b for Novel Mood Disorder Therapeutics

SHORT DESCRIPTION Novel inhibitors that disrupt TRIP8b-HCN binding to offer an alternative antidepressant mechanism for treatment of mood disorders. INVENTORS Gary Schiltz* Weinberg College of Arts and Sciences, Department of Chemistry Dane Chetkovich Ye Han Iredia Iyamu Kyle Lyman *...

Published: 6/17/2026 | Updated: 6/17/2026 | Inventor(s):

Keywords(s): Antidepressant, BIO2026, Depression, Mood disorder, Neurologic disease, Neurology, Psychiatric disorder, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Protein Degraders of NSD2 for Targeted Treatment of Head and Neck Cancers

SHORT DESCRIPTION Targeted protein degraders that selectively eliminate NSD2 for improved treatment of head and neck cancers. INVENTORS Gary Schiltz* Weinberg College of Arts and Sciences, Department of Chemistry Yanis Boumber * Principal Investigator NU Tech ID: NU 2023-140 IP STATUS U.S....

Published: 6/16/2026 | Updated: 6/16/2026 | Inventor(s):

Keywords(s): BIO2026, Cancer/Oncology, Head and neck cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders

NU 2016-137B INVENTORS Richard Silverman Weinberg College of Arts and Sciences, Department of Chemistry SHORT DESCRIPTION Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression of nNOS (e.g., gliomas, ovarian cancer) as well as neurodegenerative...

Published: 6/17/2026 | Updated: 6/16/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, ALS - Amyotrophic Lateral Sclerosis, AUTM26C1, BIAUTM1, BIO2026, Cancer/Oncology, HD - Huntington's Disease, Melanoma, Neurodegenerative disease, Neuroinflammation, Neurologic disease, nNOS, PD - Parkinson's Disease, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Biomimetic HDL Nanoparticles for Treatment of Cancer, Immune and Inflammatory Disorders, and Cardiovascular Disease

SHORT DESCRIPTION Self-assembling biomimetic high-density lipoprotein nanoparticle (HDL NP) platform technology with a soft organic core, designed to more closely replicate key functional properties of mature human HDL for therapeutic use in cardiovascular disease, cancer, and inflammatory/immune disorders. INVENTORS Colby Thaxton* Northwestern...

Published: 6/16/2026 | Updated: 6/16/2026 | Inventor(s):

Keywords(s): Atherosclerosis, Autoimmune disease, BIO2026, Breast cancer, Cancer/Oncology, Cardiology and Cardiovascular disease, Gene therapy, Immunology, Immunotherapy, Inflammation, Nanomaterials, Nanoparticle, Nanotechnology, Nucleic Acids, Platform technology, Prostate cancer, Research tool, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics

Retargetable and Metabolically Tunable CAR Cell Platforms for Durable, Antigen‑Specific Cancer Therapy

SHORT DESCRIPTION A modular immunotherapy platform that combines hapten‑redirectable chimeric antigen receptor (CAR) constructs with itaconate‑programmed, memory‑like immune cells to deliver safer, more durable, and tunable antigen‑specific responses across hematologic and solid tumors. NU TECH ID NU 2023-021, NU 2024-077 INVENTORS Ashima...

Published: 6/10/2026 | Updated: 6/10/2026 | Inventor(s):

Keywords(s): Autoimmune disease, Cancer Treatment, Cancer/Oncology, Cell therapy, Immunology, Immunotherapy, Inflammation, Leukemia, Lymphoma, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Novel Aminotransferase Inhibitor Platform for the Treatment of Cancer and Neurological Disorders

SHORT DESCRIPTION Novel Aminotransferase Mechanism-Based Inhibitor (MBI) Platform Targeting OAT and GABA-AT as Novel Treatments for Cancer and Neurological Disorders. INVENTORS Richard Silverman* Weinberg College of Arts and Sciences, Department of Chemistry * Principal Investigator DEVELOPMENT...

Published: 6/17/2026 | Updated: 6/1/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, BIO2026, Cancer/Oncology, CNS - Central Nervous System, Colon cancer, Epilepsy, Gastric cancer, Liver cancer, Lung cancer, Neurodegenerative disease, Neurologic disease, Neurology, Pancreatic cancer, PD - Parkinson's Disease, Psychiatric disorder, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Fatty-Acid Modified Cytotoxins and Peptides for Improved Efficacy, Safety, and Dosing Flexibility

SHORT DESCRIPTION A suite of four complementary technologies for a long-chain fatty‑acid–guided drug delivery platform to achieve superior therapeutic outcomes with reduced toxicity across both oncology and critical care applications. INVENTORS Nathan Gianneschi*, and others Weinberg College of Arts and Sciences,...

Published: 6/2/2026 | Updated: 6/1/2026 | Inventor(s):

Keywords(s): Adjunct therapy, BIO2026, Biologic, Breast cancer, Cancer/Oncology, Chemotherapy, Colon cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Piperacillin for Targeted Lyme Disease Treatment

SHORT DESCRIPTION For infectious disease clinicians, this piperacillin-based therapeutic approach targets Lyme disease by inhibiting bacterial cell wall synthesis to reduce disease progression. INVENTORS INVENTORS Brandon Jutras* Northwestern University Feinberg School of Medicine, Department of Microbiology-Immunology ...

Published: 6/3/2026 | Updated: 5/18/2026 | Inventor(s):

Keywords(s): Infectious disease, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Antisense Oligonucleotides to Prevent Genetic Mis-Splicing for ALS/FTD Therapeutics

SHORT DESCRIPTION Antisense oligonucleotides (ASOs) that correct TDP‑43–dependent mis‑splicing of KCNQ2 thereby reducing neuronal hyperexcitability in ALS/FTD and related TDP‑43 proteinopathies. INVENTORS Evangelos Kiskinis* Northwestern University Feinberg School of Medicine, Department of Neurology Jonathan...

Published: 6/16/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): ALS - Amyotrophic Lateral Sclerosis, BIO2026, FTD - Frontotemporal Dementia, Neurodegenerative disease, Neurologic disease, Neurology, Nucleic Acids, Rare diseases, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

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