Search Results - yamin+li

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Utilize lipid nanoparticle-based CRISPR/Cas9 genome editing to delete the Pfkp gene for the treatment of head and neck cancer

This technology introduces a novel lipid nanoparticle-based CRISPR/Cas9 system designed to target the Pfkp gene for the effective treatment of head and neck cancer. Background: Head and neck cancer continues to pose a significant clinical challenge due to its aggressive nature and poor patient prognosis. A primary contributing factor is the overexpression...

Published: 6/22/2026 | Updated: 6/21/2026 | Inventor(s): Yamin Li

Keywords(s): cancer, cancer therapy, lipids, nanoparticle, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics and Vaccines

Lipid nanoparticles for lung-targeted mRNA delivery

This technology is a new lipid nanoparticle system that can safely, specifically, and efficiently deliver mRNA to a patient’s lungs. Background: Therapeutics that deliver mRNA to a patient’s lungs offer significant potential for treating a broad spectrum of lung diseases. However, specifically and efficiently delivering mRNA to lung tissue...

Published: 6/22/2026 | Updated: 6/21/2026 | Inventor(s): Yamin Li, David Popoola, Zhi Cao, Yuqin Men

Keywords(s): biomaterials, chemistry, drug delivery, gene therapy, nanoparticle drug delivery, RNA, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Pancreas-specific mRNA delivery enabled by sulfonium lipid nanoparticles

This technology presents a novel class of lipid nanoparticles engineered for targeted delivery of mRNA specifically to the pancreas following systemic administration. Background: Effective delivery of RNA therapeutics to specific organs remains a significant challenge in biomedical research. The pancreas, in particular, has been a difficult target...

Published: 6/12/2026 | Updated: 6/11/2026 | Inventor(s): Yamin Li, Yuqin Men

Keywords(s): mRNA, nanoparticle-enhanced delivery, nanoparticles, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery

A lung-targeting britannin-lipid nanoparticle formulation and use thereof

This technology is a novel lung-targeting britannin-lipid nanoparticle formulation designed to effectively treat acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) by inhibiting lung inflammation. Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe lung conditions characterized by intense...

Published: 6/12/2026 | Updated: 6/11/2026 | Inventor(s): Yamin Li, Qinghe Meng, Daping Fan

Keywords(s): acute lung injury, drug delivery, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery

Lung-targeting mRNA-lipid nanoparticles for the treatment of acute lung injury

This technology uses lung-targeting lipid nanoparticles to deliver IL-10 mRNA directly to the lungs, reducing inflammation and injury in conditions like acute lung injury and ARDS, while minimizing side effects and improving treatment effectiveness. Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe, life-threatening...

Published: 3/19/2026 | Updated: 3/19/2026 | Inventor(s): Yamin Li, Yuqin Men, Qinghe Meng, Robert Cooney

Keywords(s): anti-inflammatory therapeutic, drug delivery, lipids, mRNA, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare

Lipid nanoparticles for targeted delivery of therapeutic agents in acute lung injury

This technology uses lung-targeting lipid nanoparticles to deliver a combination of anti-inflammatory and immune-modulating drugs directly to the lungs, offering a more effective and targeted treatment for acute lung injury and acute respiratory distress syndrome. Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)...

Published: 4/2/2026 | Updated: 1/15/2026 | Inventor(s): Yamin Li, Yuqin Men, Robert Cooney, Qinghe Meng

Keywords(s): acute lung injury, anti-inflammatory therapeutic, drug delivery, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery

Sulfonium Lipid Nanoparticles for Intranasal mRNA Delivery to Lung Epithelial and Immune Cells

This technology uses specially designed sulfonium lipid nanoparticles to deliver mRNA directly to lung cells through the nose, offering a non-invasive, more effective and targeted treatment for pulmonary diseases like asthma and cystic fibrosis. Background: The field of pulmonary medicine faces significant challenges in the treatment of diseases...

Published: 6/3/2026 | Updated: 1/9/2026 | Inventor(s): Yamin Li, Yuqin Men

Keywords(s): active pharmaceutical ingredient, chemicals, drug delivery, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery

Transgenic Mouse Model for Marfan Syndrome Research

Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...

Published: 12/23/2025 | Updated: 12/23/2025 | Inventor(s): Li Li, Shichao Wu, Jiawei Zhao

Keywords(s):

Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic

Gene Editing for Head and Neck Cancer Treatment

Application Method for delivering gene-editing therapeutic in head and neck cancers. Key Benefits CRISPR/CAS9-based gene editing mechanism targeting novel disease-modifying gene. Liquid nanoparticle encapsulation permitting in vivo delivery. Market Summary Head and neck cancers (HNC) are the 7th most common global cancer, accounting for 3%...

Published: 5/22/2026 | Updated: 11/7/2025 | Inventor(s): Yong Teng, Yamin Li

Keywords(s): Drug Discovery, Drug Target Identification, Gene Therapy and Editing, Nanoparticle Drug Delivery, Oncology Treatments, Reagents, Biomaterials, and Plasmids

Category(s): TechPub Algolia > Therapeutics

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 6/17/2026 | Updated: 1/13/2022 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

Keywords(s):

Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

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