Search Results - joseph+sodroski

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Improved CD-4 Mimetic Compounds HIV Treatment
Indoline core CD-4 mimetics are a HIV treatment that trick the virus into entering a vulnerable “open” conformation, allowing antibody-dependent cellular toxicity. Problem: HIV impacts 38 million individuals worldwide, many of whom are receiving treatment. A barrier to successful treatment is viral rebound after cessation of antiviral therapy....
Published: 6/25/2026   |   Updated: 6/25/2026   |   Inventor(s): Amos Smith, Christopher Fritschi, Joseph Sodroski
Keywords(s): HIV/AIDS, Infectious Disease, Small Molecule
Category(s): Technology Classifications > Therapeutics
Small-Molecule Therapeutic for Stabilizing HIV-1 Envelope Proteins to Increase Immune Response
Small-molecule inhibitor that prolongs exposure of HIV-1 to broadly neutralizing antibodies to suppress viral entry and infection Problem: The human immunodeficiency virus (HIV-1) infects human cells through binding of its envelope proteins to surface-expressed CD4 and CCR5 receptors. Broadly neutralizing antibodies can recognize the native, functional...
Published: 6/25/2026   |   Updated: 6/25/2026   |   Inventor(s): Amos Smith, Althea Lang, Joseph Sodroski
Keywords(s): Drug Target, HIV/AIDS, Immunology, Infectious Disease
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis