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Search Results - amos+smith
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Improved CD-4 Mimetic Compounds HIV Treatment
Indoline core CD-4 mimetics are a HIV treatment that trick the virus into entering a vulnerable “open” conformation, allowing antibody-dependent cellular toxicity. Problem: HIV impacts 38 million individuals worldwide, many of whom are receiving treatment. A barrier to successful treatment is viral rebound after cessation of antiviral therapy....
Published: 6/25/2026
|
Updated: 6/25/2026
|
Inventor(s):
Amos Smith
,
Christopher Fritschi
,
Joseph Sodroski
Keywords(s):
HIV/AIDS
,
Infectious Disease
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Small-Molecule Therapeutic for Stabilizing HIV-1 Envelope Proteins to Increase Immune Response
Small-molecule inhibitor that prolongs exposure of HIV-1 to broadly neutralizing antibodies to suppress viral entry and infection Problem: The human immunodeficiency virus (HIV-1) infects human cells through binding of its envelope proteins to surface-expressed CD4 and CCR5 receptors. Broadly neutralizing antibodies can recognize the native, functional...
Published: 6/25/2026
|
Updated: 6/25/2026
|
Inventor(s):
Amos Smith
,
Althea Lang
,
Joseph Sodroski
Keywords(s):
Drug Target
,
HIV/AIDS
,
Immunology
,
Infectious Disease
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Chemical Processes and Synthesis
Small Molecules That Expose HIV Env Sites To Trigger Targeted Immune Killing
This technology uses small molecules to bind HIV Env on infected cells, expose hidden sites, and trigger ADCC, enabling the immune system to kill cells that current therapies cannot reach. By improving antibody recognition and reducing infectious virus production, it provides a complementary approach that directly targets infected cells rather than...
Published: 12/1/2025
|
Updated: 12/1/2025
|
Inventor(s):
Amos Smith
,
Melissa Grenier-Davies
,
Andres Finzi
,
Jean-Philippe Chapleau
,
Shilei Ding
Keywords(s):
HIV/AIDS
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
A Potent HIV Treatment with Low Toxicity
A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells. Problem: 37 million people worldwide currently live with HIV and an estimated 2-3 million new infections occur annually. While antiretroviral therapies do exist for those with the disease, therapy interruption leads to the re-emergence of...
Published: 11/11/2025
|
Updated: 10/30/2025
|
Inventor(s):
Amos Smith
,
Xuchen Zhao
,
Tyler Higgins
,
Andres Finzi
,
Shilei Ding
,
Daniel Lee
,
Marzena Pazgier
,
Dung Nguyen
,
William Tolbert
Keywords(s):
Drug Target
,
HIV/AIDS
,
Small Molecule
,
Soft Materials
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Therapeutics
A Difluoromethylene Linchpin/Synthon For Creating With High Diasteroselectivity
Diverse difluoromethylene scaffolds via novel, organodifluorine synthons. Problem: Organofluorine compounds are used in numerous applications across society, including in refrigerants, pharmaceutical ingredients, and agrochemicals. Most current methods to incorporate fluorine atoms into organic compounds use monovalent synthons, which only permit...
Published: 9/26/2025
|
Updated: 10/3/2024
|
Inventor(s):
Amos Smith
,
Kevin O'Brien
,
Jonathan Nadraws
Keywords(s):
Category(s):
Technology Classifications > Chemical Processes and Synthesis
Novel Inhibitors of Ferroptosis
Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...
Published: 8/1/2025
|
Updated: 5/12/2023
|
Inventor(s):
Robert Wilson
,
Maria Cotticelli
,
Shujuan Xia
,
Donna Huryn
,
Amos Smith
,
Taehee Lee
,
Roberto Forestieri
Keywords(s):
Neurodegenerative Diseases
Category(s):
Technology Classifications > Therapeutics
Novel Pyrimidine Derivatives to Treat Alzheimer’s Disease
Brain penetrating compounds as promising therapeutics for treatment of neurodegenerative disorders. Problem: An estimated 6.2 million Americans live with Alzheimer’s Disease (AD), and this number is projected to reach over 13 million by 2050 with societal costs expected to rise to $1.1 trillion. A key feature of AD-affected brain tissue is the...
Published: 8/21/2025
|
Updated: 3/16/2021
|
Inventor(s):
Kurt Brunden
,
Carlo Ballatore
,
Amos Smith
,
Virginia Lee
,
John Trojanowski
Keywords(s):
Aging
,
Neurodegenerative Diseases
,
Neurology
,
Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Therapeutics
Reusable silicon-based cross-coupling agents for the production of natural products, pharmaceuticals, and other organic materials
Cross-coupling reactions without the generation of waste products Problem: Catalytic carbon-carbon bond formation based on cross-coupling reactions (CCRs) plays a central role in the production of natural products, pharmaceuticals, agrochemicals, and organic materials. Coupling reactions with organometallic reagents and organic halides facilitate...
Published: 12/12/2025
|
Updated: 3/20/2020
|
Inventor(s):
Amos Smith
Keywords(s):
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Materials
CD4 mimetic small molecule inhibitors of HIV-1 entry
Therapeutic development for HIV-1 infection and prevention of transmission Problem: A global pandemic of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) persists, with about 34 million people worldwide currently infected and 2.5 million people newly infected with the virus annually. Inhibition of the initial HIV...
Published: 9/26/2025
|
Updated: 3/19/2020
|
Inventor(s):
Amos Smith
Keywords(s):
HIV/AIDS
,
Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Therapeutics
A novel isostere to replace the carboxylic acid functional group in pharmaceuticals and other compounds
Cycloalkyl-dione derivatives with improved pharmacokinetic and toxicological properties for drug design Problem: Isosteric replacement of a specific group of atoms with a moiety with similar physicochemical properties is a strategy employed by medicinal chemists to improve the properties of biologically active compounds. For example, carboxylic...
Published: 12/12/2025
|
Updated: 3/19/2020
|
Inventor(s):
Amos Smith
,
Donna Huryn
,
Carlo Ballatore
,
Virginia Lee
,
John Trojanowski
Keywords(s):
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Materials
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