Search Results - donna+huryn

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Safe and Highly Selective HDAC8 Inhibitors for Kidney Disease and Precision Therapies
HDAC8-targeting small molecules for kidney disease treatment with improved safety, selectivity, and therapeutic potential. Problem: Acute kidney injury (AKI) and focal segmental glomerulosclerosis (FSGS) affect millions of patients worldwide and can contribute to chronic kidney disease and end-stage renal failure, which only has a 5-year survival rate...
Published: 6/30/2026   |   Updated: 6/30/2026   |   Inventor(s): Donna Huryn, Neil Hukriede
Keywords(s): Drug Target, Nephrology and Urology, Small Molecule
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Novel Inhibitors of Ferroptosis
Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...
Published: 8/1/2025   |   Updated: 5/12/2023   |   Inventor(s): Robert Wilson, Maria Cotticelli, Shujuan Xia, Donna Huryn, Amos Smith, Taehee Lee, Roberto Forestieri
Keywords(s): Neurodegenerative Diseases
Category(s): Technology Classifications > Therapeutics
Up-regulators of utrophin expression for the treatment of muscular dystrophy
Small molecules targeting utrophin mRNA untranslated regions overcome post-transcriptional repression Problem: Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disorder that affects approximately 1 in 3500 males worldwide. DMD is caused by mutations in the DMD gene that lead to severe reduction or loss of dystrophin protein. Without...
Published: 8/1/2025   |   Updated: 4/28/2020   |   Inventor(s): Tejvir Khurana, Donna Huryn
Keywords(s): Drug Target, Genetic Disorders
Category(s): Technology Classifications > Therapeutics
A novel isostere to replace the carboxylic acid functional group in pharmaceuticals and other compounds
Cycloalkyl-dione derivatives with improved pharmacokinetic and toxicological properties for drug design Problem: Isosteric replacement of a specific group of atoms with a moiety with similar physicochemical properties is a strategy employed by medicinal chemists to improve the properties of biologically active compounds. For example, carboxylic...
Published: 12/12/2025   |   Updated: 3/19/2020   |   Inventor(s): Amos Smith, Donna Huryn, Carlo Ballatore, Virginia Lee, John Trojanowski
Keywords(s):  
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials