Search Results - juntao+luo

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CMT-3 nanoformulations for systemic and local administration for inflammation control
The technology introduces innovative telodendrimer nanoformulations of the anti-inflammatory agent CMT-3 that enhance its solubility and bioavailability for effective systemic and local inflammation control. Background: CMT-3 is a potent anti-inflammatory compound with promising therapeutic potential; however, its poor water solubility significantly...
Published: 6/22/2026   |   Updated: 6/21/2026   |   Inventor(s): Juntao Luo, Robert Cooney, Qinghe Meng, Xiaojing Wang, Dandan Guo, Gary Nieman
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
Mithramycin prodrug nanoformulations for improved disease treatment
This technology introduces a novel nano-formulation of Mithramycin A designed to improve cancer treatment effectiveness while significantly reducing associated liver toxicity. Background: Mithramycin A (MithA) is a potent inhibitor of RNA synthesis that binds to DNA and has demonstrated effectiveness against a specific oncogene found in Ewing sarcoma,...
Published: 6/22/2026   |   Updated: 6/21/2026   |   Inventor(s): Juntao Luo, Jason Horton, Dandan Guo, Mei Yun Lin
Keywords(s): cancer therapy, nanomedicine, targeted drug delivery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Design and Synthesis
Prodrug Nanoformulations of Amphotericin B conjugated Phenylboronic acid containing Telodendrimer Nanocarriers in Systemic Fungal Infections Treatment
This technology uses telodendrimer prodrugs combined with boronate chemistry to improve drug delivery and effectiveness. Background: The field of drug delivery has seen significant advancements over the past few decades, particularly in the development of targeted therapies that can improve the efficacy and safety profiles of pharmaceutical agents....
Published: 6/22/2026   |   Updated: 6/16/2026   |   Inventor(s): Juntao Luo, Dandan Guo, Changying Shi
Keywords(s): Technologies
Category(s): Technology Classifications > Drug Delivery, Campus > Upstate Medical University
Bioactive Telodendrimer Nanocarrier for Antibiotics Delivery and Immune Modulation
Novel telodendrimer nanoparticles have been developed to enhance the delivery and safety profile of the antibiotic Polymyxin B by improving its stability and reducing toxicity during treatment. Background: Polymyxin B (PMB) is a powerful antibiotic used to treat infections caused by Gram-negative bacteria, but its clinical application is limited...
Published: 6/12/2026   |   Updated: 6/12/2026   |   Inventor(s): Juntao Luo, Dandan Guo, Md Shanewaz Hossan, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
Development of novel liver-targeting glucocorticoid prodrugs
This technology presents novel liver-targeting glucocorticoid prodrugs designed to improve the treatment of inflammatory liver diseases and sepsis with enhanced efficacy and reduced systemic side effects. Background: Inflammatory liver diseases and sepsis represent significant clinical challenges due to their complex immune responses and the difficulty...
Published: 6/12/2026   |   Updated: 6/11/2026   |   Inventor(s): Hong Lu, Juntao Luo, Dandan Guo
Keywords(s): glucocorticoid, inflammatory liver disease, liver-selective, nanoparticle, prodrug, sepsis, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
Metal organic framework membranes for ion transport and separation
Background Ion-selective separation membranes play a critical role in applications such as water purification, energy storage, and chemical processing. These tech­nologies are essential for tackling global challenges like clean water scarcity, efficient energy utilization, and sustainable industrial processes. Traditional ion separation methods,...
Published: 5/12/2026   |   Updated: 12/3/2025   |   Inventor(s): Huacheng Zhang, Xingya Li, Huanting Wang, Jun Lu, Anita Hill, Benny Freeman
Keywords(s):  
Category(s): Physical sciences > Materials > Membranes
Engineered Telodendrimer Nanocarriers for Monomeric Amphotericin B Delivery
A nanocarrier platform for Amphotericin B that improves efficacy and reduces cost, while decreasing toxicity. Background: Systemic fungal infections are an increasingly prevalent health problem. The hydrophobic polyene antibiotic Amphotericin B (AmB) is the drug of choice for these life-threatening invasive fungal infections. Unfortunately, it produces...
Published: 1/29/2026   |   Updated: 5/13/2025   |   Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics and Vaccines
Injectable Nanogel for Immune Modulation Therapy
A platform for effective therapeutic delivery and immune modulation for effective and quick inflammation control in critical illness, including sepsis. Background: Immune modulation therapy is a type of immunotherapy that enhances the body’s immune regulation and homeostasis. This therapy has proved promising for the treatment of some types...
Published: 1/30/2026   |   Updated: 5/13/2025   |   Inventor(s): Juntao Luo, Xiaotian Ji, Changying Shi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
A Nanotrap to Improve Survival in Severe Sepsis by Attenuating Hyperinflammation Through Hemoperfusion
This optimized nanotrap therapy in combination with a moderate antibiotic treatment resulted in a 100% survival rate in severe septic mice. Background: The mortality rates in severe sepsis patients are 30‑41%. In the U.S. alone, 1.7 million people develop sepsis on a yearly basis. Effective therapies to prevent or treat the cytokine storm or septic...
Published: 1/30/2026   |   Updated: 5/13/2025   |   Inventor(s): Juntao Luo, Lili Wang, Changying Shi
Keywords(s):  
Category(s): Campus > Upstate Medical University, Technology Classifications > Nanotechnology
Customized Telodendrimer Nanocarriers for Targeted Drug Delivery for Disease Treatments
A suite of nanocarrier technologies that provide targeted drug delivery of hydrophobic and hydrophilic drugs to specific disease sites. Background: Delivery of therapeutic and diagnostic compounds is limited by the lack of efficient carriers to improve in vivo stability, selectivity as well as to reduce immunogenicity. Conventional nanocarrier design...
Published: 6/12/2026   |   Updated: 5/13/2025   |   Inventor(s): Juntao Luo, Dandan Guo, Changying Shi
Keywords(s): #SUNYresearch, affinity alkylating agent, autoimmune, autoimmune disease, bioactivity, biocompatible, biomaterials, chemical formulation, chemistry, cisplatin, combintorial conjugated dendrimer, dendritic drug delivery, drug delivery component, drug formulation, Featured, graft rejection, hydrophilic drug, hydrophobic drug, immune modulating, immunogenicity inflammation, inflammatory, inflammatory, inflammatory, inflammatory, inflammatory response, inflammatory response, intracellular delivery, methotrexate, moieties, nanocarriers, nanomedicine, nanoparticle, nanoparticle drug delivery, nanoparticle-enhanced delivery, nanotherapy, polyethylene glycol, polymyxin, targeted biologics delivery, targeted delivery, targeted drug delivery, targeted therapeutic delivery, targeting drug, Technologies, therapeutic drug, topoisomerase, vitamin E
Category(s): Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University
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