Search Results - glucocorticoid

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Development of novel liver-targeting glucocorticoid prodrugs
This technology presents novel liver-targeting glucocorticoid prodrugs designed to improve the treatment of inflammatory liver diseases and sepsis with enhanced efficacy and reduced systemic side effects. Background: Inflammatory liver diseases and sepsis represent significant clinical challenges due to their complex immune responses and the difficulty...
Published: 6/12/2026   |   Updated: 6/11/2026   |   Inventor(s): Hong Lu, Juntao Luo, Dandan Guo
Keywords(s): glucocorticoid, inflammatory liver disease, liver-selective, nanoparticle, prodrug, sepsis, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
A novel synthetic constitutive-active glucocorticoid receptor
Introducing "superGR," a novel synthetic glucocorticoid receptor fusion protein designed to enhance glucocorticoid therapy by providing ligand-independent activation and improved gene regulation for inflammatory diseases. Background: Glucocorticoids are widely used to treat inflammatory conditions like severe alcoholic hepatitis and sepsis,...
Published: 3/9/2026   |   Updated: 2/19/2026   |   Inventor(s): Hong Lu, Conor Fahy
Keywords(s): gene therapy, glucocorticoid, inflammatory liver disease, lung injury, sepsis, synthetic materials, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
Human Phospho-Serine134 Glucocorticoid Receptor Polyclonal Antibody: Useful for the Characterization of Glucocorticoid Signaling Processes, e.g., in Cancer and Inflammation
The glucocorticoid receptor (GR) functions as a hormone-dependent transcription factor that is involved in the maintenance of basal and stress-related homeostasis. Serine 134 is a newly discovered phosphorylation target on the human glucocorticoid receptor that becomes phosphorylated during stress-activating conditions such as ultraviolet irradiation,...
Published: 10/28/2024   |   Updated: 12/6/2022   |   Inventor(s): John Cidlowski, Amy Beckley
Keywords(s): AC5XXX, ACXXXX, ANTIBODY, CANCER, Glucocorticoid, Glucocorticoid Receptor, Human, Phospho-Serine134, STRESS, Stress-mediated
Category(s): Collaboration Sought > Collaboration