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Transcription Factors in B cells as Targets for Therapeutic Modulation in SLE
This technology introduces a novel therapeutic approach for systemic lupus erythematosus (SLE) by modulating specific transcription factors in B cells to restore immune tolerance and prevent autoimmunity. Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of harmful autoantibodies from self-reactive...
Published: 6/29/2026   |   Updated: 6/24/2026   |   Inventor(s): Christopher Roman, Abhimanyu Amarnani
Keywords(s): autoimmune disease, autoimmunity, drug mechanism, gene expression analysis, immune disease, lupus, molecular pharmacology, targeted therapeutic delivery, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
A novel SHIP1-selective inhibitor to induce blood cell recovery and stem cell engraftment
A32 is a highly selective small molecule that inhibits the SHIP1 enzyme, boosting blood cell growth factors and potentially improving recovery and immunity after chemotherapy, radiation, or stem cell transplantation, without affecting the related SHIP2 enzyme. Background: Hematopoiesis, the process by which blood cells are formed, is critical for...
Published: 6/29/2026   |   Updated: 6/24/2026   |   Inventor(s): William Kerr, Chiara Pedicone, Denzil Bernard
Keywords(s): bleeding disorders, Blood cell recovery, fungal infection, neutrophils, platelets, stem cell transplants, Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
Utilize lipid nanoparticle-based CRISPR/Cas9 genome editing to delete the Pfkp gene for the treatment of head and neck cancer
This technology introduces a novel lipid nanoparticle-based CRISPR/Cas9 system designed to target the Pfkp gene for the effective treatment of head and neck cancer. Background: Head and neck cancer continues to pose a significant clinical challenge due to its aggressive nature and poor patient prognosis. A primary contributing factor is the overexpression...
Published: 6/22/2026   |   Updated: 6/21/2026   |   Inventor(s): Yamin Li
Keywords(s): cancer, cancer therapy, lipids, nanoparticle, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics and Vaccines
Lipid nanoparticles for lung-targeted mRNA delivery
This technology is a new lipid nanoparticle system that can safely, specifically, and efficiently deliver mRNA to a patient’s lungs. Background: Therapeutics that deliver mRNA to a patient’s lungs offer significant potential for treating a broad spectrum of lung diseases. However, specifically and efficiently delivering mRNA to lung tissue...
Published: 6/22/2026   |   Updated: 6/21/2026   |   Inventor(s): Yamin Li, David Popoola, Zhi Cao, Yuqin Men
Keywords(s): biomaterials, chemistry, drug delivery, gene therapy, nanoparticle drug delivery, RNA, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Targeting Hypoxia-inducible factor 2alpha in cancer
This technology offers a novel approach for new cancer treatments based on inhibiting HIF2α-related processes. Background: Hypoxia-inducible factor 2α (HIF2α) transcription factor is involved in the adaptation of cancer cells (including clear cell renal cell carcinoma (ccRCC)) to low oxygen conditions (hypoxia). It plays a role...
Published: 6/15/2026   |   Updated: 6/15/2026   |   Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Dimitra Bourboulia, Mark Woodford, John Chisholm
Keywords(s): cancer, cancer therapy, cell proliferation, regulation of transcriptional dynamics, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Reduction of Lipid Accumulation Reverses Aging
Therapeutic strategy to treat age-related cardiovascular disease and restore cardiovascular function through maintenance of lipid homeostasis. Background: Age is a key risk factor for cardiovascular disease such as atherosclerosis, which is characterized by endothelial dysfunction, extracellular matrix remodeling, lipid accumulation, chronic inflammation...
Published: 6/19/2026   |   Updated: 6/15/2026   |   Inventor(s): Stylianos Andreadis, Yulun Wu, Pihu Mehrotra
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
Small molecule inhibition of SHIP1 induces broad activation of natural killer cells
This technology involves methods to activate natural killer (NK) cells by inhibiting the SHIP1 enzyme, offering new therapeutic approaches to treat cancers and infectious diseases. Background: Natural killer (NK) cells play a vital role in the body's innate immune defense, targeting and eliminating tumor cells and infected cells. However, their...
Published: 6/15/2026   |   Updated: 6/15/2026   |   Inventor(s): William Kerr, Matthew Gumbleton
Keywords(s):  
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Methods and Compositions for Prevention and Mitigation of Radiation-Induced Cardiac Injury Using GLP-1 Receptor Agonists
This technology utilizes glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide, to prevent and treat radiation-induced cardiac injury, offering a novel medical approach to protect the heart from damages caused by ionizing radiation. Background: Radiation-induced heart disease (RIHD) is a serious complication arising from exposure...
Published: 6/22/2026   |   Updated: 6/12/2026   |   Inventor(s): Snehalata Pawar, Suresh Veeraperumal
Keywords(s): cardiovascular, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Enhancement of adaptive immune responses by post-inoculation administration of fenretinide (N-(4-hydroxyphenyl)retinamide)
This technology uses fenretinide, a synthetic vitamin A derivative, to boost the body’s adaptive immune response after vaccination or infection, making vaccines more effective, especially for poorly immunogenic agents or immunocompromised individuals, without increasing infection severity. Background: The field of vaccine development and immunotherapy...
Published: 6/1/2026   |   Updated: 5/29/2026   |   Inventor(s): Adam Waickman, Stephen Thomas, David Foster, Herbert Slade
Keywords(s): Technologies, vaccine stability, vaccines
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Bruton's Tyrosine Kinase as Anti-Cancer Drug Target
This technology identifies Bruton's Tyrosine Kinase (BTK) as a novel target in breast cancer therapy and provides methods for treatment and diagnosis by inhibiting a specific BTK variant. Background: Protein tyrosine kinases (PTKs) are essential enzymes involved in cellular communication and regulation, often playing a significant role in cancer...
Published: 5/5/2026   |   Updated: 5/4/2026   |   Inventor(s): Douglas Conklin, Antonis Kourtidis, Cheryl Eifert
Keywords(s): breast cancer, cancer, TAF, Technologies, therapeutic targets
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany
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