Search Results - mark+woodford

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Targeting Protein Phosphatase-5 in Cancer
This technology introduces a novel approach to cancer treatment by targeting Protein Phosphatase 5 (PP5) to regulate apoptosis and inhibit tumor growth, particularly in clear cell renal cell carcinoma (ccRCC). Background: Cancer cells often evade programmed cell death, allowing tumors to grow unchecked. In clear cell renal cell carcinoma, dysregulation...
Published: 6/22/2026   |   Updated: 6/16/2026   |   Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, John Chisholm, Dimitra Bourboulia, Mark Woodford
Keywords(s): cancer, cancer therapy, phosphorylation, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy
Targeting Hypoxia-inducible factor 2alpha in cancer
This technology offers a novel approach for new cancer treatments based on inhibiting HIF2α-related processes. Background: Hypoxia-inducible factor 2α (HIF2α) transcription factor is involved in the adaptation of cancer cells (including clear cell renal cell carcinoma (ccRCC)) to low oxygen conditions (hypoxia). It plays a role...
Published: 6/15/2026   |   Updated: 6/15/2026   |   Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Dimitra Bourboulia, Mark Woodford, John Chisholm
Keywords(s): cancer, cancer therapy, cell proliferation, regulation of transcriptional dynamics, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Small Peptides Targeting Lactate Dehydrogenase-A
This technology presents engineered peptide inhibitors designed to selectively block lactate dehydrogenase A (LDHA) activity, offering a novel therapeutic approach for diseases characterized by elevated LDHA, such as cancer and metabolic disorders. Background: Lactate dehydrogenase A (LDHA) is an enzyme that plays a key role in cellular metabolism...
Published: 6/12/2026   |   Updated: 6/12/2026   |   Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Mark Woodford
Keywords(s): FLCN, lactate dehydrogenase, metabolic switch, tumor suppressor, Warburg effect
Category(s): Campus > Upstate Medical University
Targeting the Folding of Hsp90 Clients by Predicting Their Local Unfolding Status
Computationally predicts potential ideal interaction points for the molecular chaperone heat shock protein-90 (Hsp90). Background: Molecular chaperones assist in the folding of unfolded and misfolded polypeptides by stabilization of folding intermediates and prevention of protein misfolding and aggregation. Molecular chaperones are present in all...
Published: 6/12/2026   |   Updated: 5/13/2025   |   Inventor(s): Mehdi Mollapour, Giorgio Colombo, Mark Woodford, Gennady Bratslavsky, Dimitra Bourboulia
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines