Search Results - dimitra+bourboulia

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This technology introduces novel compositions and methods using mutated forms of TIMP-2 to precisely regulate extracellular MMP-2 activity, offering targeted control over tissue remodeling processes. Background: Matrix metalloproteinase-2 (MMP-2) plays a vital role in remodeling the extracellular matrix, which is essential for normal physiological...

Published: 6/22/2026 | Updated: 6/16/2026 | Inventor(s): Dimitra Bourboulia, Mehdi Mollapour, Gennady Bratslavsky

Keywords(s): antibody, extracellular kinase, inhibition, phosphorylation

Category(s): Campus > Upstate Medical University

Targeting Protein Phosphatase-5 in Cancer

This technology introduces a novel approach to cancer treatment by targeting Protein Phosphatase 5 (PP5) to regulate apoptosis and inhibit tumor growth, particularly in clear cell renal cell carcinoma (ccRCC). Background: Cancer cells often evade programmed cell death, allowing tumors to grow unchecked. In clear cell renal cell carcinoma, dysregulation...

Published: 6/22/2026 | Updated: 6/16/2026 | Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, John Chisholm, Dimitra Bourboulia, Mark Woodford

Keywords(s): cancer, cancer therapy, phosphorylation, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy

Targeting Hypoxia-inducible factor 2alpha in cancer

This technology offers a novel approach for new cancer treatments based on inhibiting HIF2α-related processes. Background: Hypoxia-inducible factor 2α (HIF2α) transcription factor is involved in the adaptation of cancer cells (including clear cell renal cell carcinoma (ccRCC)) to low oxygen conditions (hypoxia). It plays a role...

Published: 6/15/2026 | Updated: 6/15/2026 | Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Dimitra Bourboulia, Mark Woodford, John Chisholm

Keywords(s): cancer, cancer therapy, cell proliferation, regulation of transcriptional dynamics, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Transgenic Mouse Model for Marfan Syndrome Research

Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...

Published: 12/23/2025 | Updated: 12/23/2025 | Inventor(s): Li Li, Shichao Wu, Jiawei Zhao

Keywords(s):

Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic

Targeting the Folding of Hsp90 Clients by Predicting Their Local Unfolding Status

Computationally predicts potential ideal interaction points for the molecular chaperone heat shock protein-90 (Hsp90). Background: Molecular chaperones assist in the folding of unfolded and misfolded polypeptides by stabilization of folding intermediates and prevention of protein misfolding and aggregation. Molecular chaperones are present in all...

Published: 6/12/2026 | Updated: 5/13/2025 | Inventor(s): Mehdi Mollapour, Giorgio Colombo, Mark Woodford, Gennady Bratslavsky, Dimitra Bourboulia

Keywords(s): Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 6/17/2026 | Updated: 1/13/2022 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

Keywords(s):

Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers

Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...

Published: 4/3/2023 | Updated: 11/30/2014 | Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources

All-Fiber Multicore Fiber Laser Devices

Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...

Published: 4/3/2023 | Updated: 1/31/2014 | Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources