Search Results - john+chisholm

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Targeting Protein Phosphatase-5 in Cancer
This technology introduces a novel approach to cancer treatment by targeting Protein Phosphatase 5 (PP5) to regulate apoptosis and inhibit tumor growth, particularly in clear cell renal cell carcinoma (ccRCC). Background: Cancer cells often evade programmed cell death, allowing tumors to grow unchecked. In clear cell renal cell carcinoma, dysregulation...
Published: 6/22/2026   |   Updated: 6/16/2026   |   Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, John Chisholm, Dimitra Bourboulia, Mark Woodford
Keywords(s): cancer, cancer therapy, phosphorylation, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy
Targeting Hypoxia-inducible factor 2alpha in cancer
This technology offers a novel approach for new cancer treatments based on inhibiting HIF2α-related processes. Background: Hypoxia-inducible factor 2α (HIF2α) transcription factor is involved in the adaptation of cancer cells (including clear cell renal cell carcinoma (ccRCC)) to low oxygen conditions (hypoxia). It plays a role...
Published: 6/15/2026   |   Updated: 6/15/2026   |   Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Dimitra Bourboulia, Mark Woodford, John Chisholm
Keywords(s): cancer, cancer therapy, cell proliferation, regulation of transcriptional dynamics, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Discovery of Novel SHIP1 Agonists
A new class of SHIP1 agonists that offer the potential for the development of new treatments for a variety of diseases. Background: An agonist is a drug or substance that binds to a cell receptor, producing the same action as the substance that would naturally bind to the receptor. Agonists form the basis for a wide variety of therapeutics. The...
Published: 3/18/2026   |   Updated: 5/13/2025   |   Inventor(s): William Kerr, Robert Anderson, John Chisholm, Sandra Denney, Shea Meyer, Angela Pacherille
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Artificial Intelligence, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare