Search Results - gennady+bratslavsky

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Customizable implantable testicular prosthetics

This innovation introduces a customizable implantable testicular prosthesis with an adjustable size, enabling precise fit and improved surgical outcomes. Background: Existing testicular prosthetics are typically available as either pre-sized balloon-type implants or solid silicone models. These fixed-size options often present challenges during surgery,...

Published: 6/29/2026 | Updated: 6/24/2026 | Inventor(s): Dmitriy Nikolavsky, Gennady Bratslavsky

Keywords(s): Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Assistive Technology

Kinase blocking inhibition in cancer

This technology introduces novel compositions and methods using mutated forms of TIMP-2 to precisely regulate extracellular MMP-2 activity, offering targeted control over tissue remodeling processes. Background: Matrix metalloproteinase-2 (MMP-2) plays a vital role in remodeling the extracellular matrix, which is essential for normal physiological...

Published: 6/22/2026 | Updated: 6/16/2026 | Inventor(s): Dimitra Bourboulia, Mehdi Mollapour, Gennady Bratslavsky

Keywords(s): antibody, extracellular kinase, inhibition, phosphorylation

Category(s): Campus > Upstate Medical University

Targeting Protein Phosphatase-5 in Cancer

This technology introduces a novel approach to cancer treatment by targeting Protein Phosphatase 5 (PP5) to regulate apoptosis and inhibit tumor growth, particularly in clear cell renal cell carcinoma (ccRCC). Background: Cancer cells often evade programmed cell death, allowing tumors to grow unchecked. In clear cell renal cell carcinoma, dysregulation...

Published: 6/22/2026 | Updated: 6/16/2026 | Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, John Chisholm, Dimitra Bourboulia, Mark Woodford

Keywords(s): cancer, cancer therapy, phosphorylation, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy

Targeting Hypoxia-inducible factor 2alpha in cancer

This technology offers a novel approach for new cancer treatments based on inhibiting HIF2α-related processes. Background: Hypoxia-inducible factor 2α (HIF2α) transcription factor is involved in the adaptation of cancer cells (including clear cell renal cell carcinoma (ccRCC)) to low oxygen conditions (hypoxia). It plays a role...

Published: 6/15/2026 | Updated: 6/15/2026 | Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Dimitra Bourboulia, Mark Woodford, John Chisholm

Keywords(s): cancer, cancer therapy, cell proliferation, regulation of transcriptional dynamics, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Small Peptides Targeting Lactate Dehydrogenase-A

This technology presents engineered peptide inhibitors designed to selectively block lactate dehydrogenase A (LDHA) activity, offering a novel therapeutic approach for diseases characterized by elevated LDHA, such as cancer and metabolic disorders. Background: Lactate dehydrogenase A (LDHA) is an enzyme that plays a key role in cellular metabolism...

Published: 6/12/2026 | Updated: 6/12/2026 | Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Mark Woodford

Keywords(s): FLCN, lactate dehydrogenase, metabolic switch, tumor suppressor, Warburg effect

Category(s): Campus > Upstate Medical University

Decision Support Tool for Detection of Prostate Lesions on MRI

Prostate cancer diagnostic software that provides expert-level lesion detection, localization, automated segmentation, and automated report generation in less than 45 seconds. Background: According to the American Cancer Society, about 1 in 8 men will be diagnosed with prostate cancer during their lifetime. American Urologic Association guidelines...

Published: 9/25/2025 | Updated: 9/25/2025 | Inventor(s): Thomas Sanford, Gennady Bratslavsky

Keywords(s): magnetic resonance imaging, oncology, prostate, software, Technologies

Category(s): Technology Classifications > Healthcare IT, Campus > Upstate Medical University

Therapeutic Lighted Catheter for Treatment and Prevention of Urethral Stricture Disease, Bladder Neck Stenosis and Anastomotic Contractures

An easy-to-use, minimally-invasive treatment that improves the efficacy of endoscopic treatments by preventing/reducing scar formation. Background: Urethral strictures cause around 1,000,000 emergency room visits in the US and nearly as many visits to urologist clinics. Treatments include urethral dilations (mechanical stretching) and endoscopic...

Published: 2/2/2026 | Updated: 5/13/2025 | Inventor(s): Dmitriy Nikolavsky, Gennady Bratslavsky

Keywords(s): anastomotic contractures, bladder neck stenosis, catheter, Technologies, urethral stricture disease, urology

Category(s): Campus > Upstate Medical University, Technology Classifications > Medical Devices, Technology Classifications > Biomedical Science and Engineering

Targeting the Folding of Hsp90 Clients by Predicting Their Local Unfolding Status

Computationally predicts potential ideal interaction points for the molecular chaperone heat shock protein-90 (Hsp90). Background: Molecular chaperones assist in the folding of unfolded and misfolded polypeptides by stabilization of folding intermediates and prevention of protein misfolding and aggregation. Molecular chaperones are present in all...

Published: 6/12/2026 | Updated: 5/13/2025 | Inventor(s): Mehdi Mollapour, Giorgio Colombo, Mark Woodford, Gennady Bratslavsky, Dimitra Bourboulia

Keywords(s): Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

Novel Suturing Device Kit

A surgical "sewing machine" for rapid graft quilting and suturing in challenging spaces. Background: Grafts are commonly employed in urologic reconstructive surgery, but anchoring them in less accessible areas -- as in luminal stenosis surgery -- can be difficult. A novel surgical "sewing machine" capable of quilting and suturing...

Published: 5/28/2026 | Updated: 5/13/2025 | Inventor(s): Dmitriy Nikolavsky, Gennady Bratslavsky

Keywords(s): #SUNYresearch, barbed suture, healthcare, medical devices, surgery, suturing technique, Technologies

Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare, Campus > Upstate Medical University