Search Results - regulation+of+transcriptional+dynamics

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Targeting Hypoxia-inducible factor 2alpha in cancer
This technology offers a novel approach for new cancer treatments based on inhibiting HIF2α-related processes. Background: Hypoxia-inducible factor 2α (HIF2α) transcription factor is involved in the adaptation of cancer cells (including clear cell renal cell carcinoma (ccRCC)) to low oxygen conditions (hypoxia). It plays a role...
Published: 6/15/2026   |   Updated: 6/15/2026   |   Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Dimitra Bourboulia, Mark Woodford, John Chisholm
Keywords(s): cancer, cancer therapy, cell proliferation, regulation of transcriptional dynamics, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
ABI1 Regulates Transcriptional Activity of Androgen Receptor by Novel DNA and AR Binding Mechanism
Provides new pathways for biomarkers and drug discovery for cancer patients. Background: The gene Abelson interactor protein-1 (ABI1) encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal...
Published: 3/18/2026   |   Updated: 7/7/2023   |   Inventor(s): Leszek Kotula, Alaji Bah, Dominique Frueh
Keywords(s): DNA, regulation of transcriptional dynamics, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines