Search Results - chiara+pedicone

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A novel SHIP1-selective inhibitor to induce blood cell recovery and stem cell engraftment
A32 is a highly selective small molecule that inhibits the SHIP1 enzyme, boosting blood cell growth factors and potentially improving recovery and immunity after chemotherapy, radiation, or stem cell transplantation, without affecting the related SHIP2 enzyme. Background: Hematopoiesis, the process by which blood cells are formed, is critical for...
Published: 6/29/2026   |   Updated: 6/24/2026   |   Inventor(s): William Kerr, Chiara Pedicone, Denzil Bernard
Keywords(s): bleeding disorders, Blood cell recovery, fungal infection, neutrophils, platelets, stem cell transplants, Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
Small Molecule Inhibitors for Alzheimer's Immunotherapy
Pan-SHIP1/2 inhibitors enhance phagocytosis of dead neurons and amyloid beta by microglia. Background: The beta-amyloid (1-42) peptide fragment is a crucial component of beta-amyloid debris that forms plaques in Alzheimer's Disease, playing a significant role in disease pathology and cognitive decline. Increased amyloid deposits and tau tangles...
Published: 1/30/2026   |   Updated: 5/13/2025   |   Inventor(s): William Kerr, Chiara Pedicone
Keywords(s): TAF, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines