Search Results - christopher+roman

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Transcription Factors in B cells as Targets for Therapeutic Modulation in SLE
This technology introduces a novel therapeutic approach for systemic lupus erythematosus (SLE) by modulating specific transcription factors in B cells to restore immune tolerance and prevent autoimmunity. Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of harmful autoantibodies from self-reactive...
Published: 6/29/2026   |   Updated: 6/24/2026   |   Inventor(s): Christopher Roman, Abhimanyu Amarnani
Keywords(s): autoimmune disease, autoimmunity, drug mechanism, gene expression analysis, immune disease, lupus, molecular pharmacology, targeted therapeutic delivery, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
Use of 2-Hydroxyoleic Acid for the Treatment of Systemic Lupus Erythematosus and Other Immune Pathologies
A novel B cell tolerance pathway activated by the lipid enzyme sphingomyelin synthases 2 (SMS2). Background: Autoimmune diseases such as Systemic Lupus Erythematosus are chronic, painful and debilitating. The Lupus Foundation of America estimates that 1.5 million Americans, and at least five million people worldwide, have some form of lupus. The...
Published: 1/30/2026   |   Updated: 5/13/2025   |   Inventor(s): Chongmin Huan, Christopher Roman, Peiqi Ou
Keywords(s): TAF, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines