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Safe and Highly Selective HDAC8 Inhibitors for Kidney Disease and Precision Therapies
HDAC8-targeting small molecules for kidney disease treatment with improved safety, selectivity, and therapeutic potential. Problem: Acute kidney injury (AKI) and focal segmental glomerulosclerosis (FSGS) affect millions of patients worldwide and can contribute to chronic kidney disease and end-stage renal failure, which only has a 5-year survival rate...
Published: 6/30/2026   |   Updated: 6/30/2026   |   Inventor(s): Donna Huryn, Neil Hukriede
Keywords(s): Drug Target, Nephrology and Urology, Small Molecule
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Improved CD-4 Mimetic Compounds HIV Treatment
Indoline core CD-4 mimetics are a HIV treatment that trick the virus into entering a vulnerable “open” conformation, allowing antibody-dependent cellular toxicity. Problem: HIV impacts 38 million individuals worldwide, many of whom are receiving treatment. A barrier to successful treatment is viral rebound after cessation of antiviral therapy....
Published: 6/25/2026   |   Updated: 6/25/2026   |   Inventor(s): Amos Smith, Christopher Fritschi, Joseph Sodroski
Keywords(s): HIV/AIDS, Infectious Disease, Small Molecule
Category(s): Technology Classifications > Therapeutics
Small-Molecule Therapeutic for Stabilizing HIV-1 Envelope Proteins to Increase Immune Response
Small-molecule inhibitor that prolongs exposure of HIV-1 to broadly neutralizing antibodies to suppress viral entry and infection Problem: The human immunodeficiency virus (HIV-1) infects human cells through binding of its envelope proteins to surface-expressed CD4 and CCR5 receptors. Broadly neutralizing antibodies can recognize the native, functional...
Published: 6/25/2026   |   Updated: 6/25/2026   |   Inventor(s): Amos Smith, Althea Lang, Joseph Sodroski
Keywords(s): Drug Target, HIV/AIDS, Immunology, Infectious Disease
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis
Durable cure for Pseudoxanthoma Elasticum: High-Efficiency, Precision-Targeted Gene Therapy
Lipid nanoparticles containing messenger RNA (mRNA-LNPs) encoding Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) base-editors that correct pseudoxanthoma elasticum-causing mutations. Problem: Pseudoxanthoma elasticum (PXE) is a genetic disorder affecting approximately 1 in 25,000 Americans. It is caused by loss-of-function mutations...
Published: 6/17/2026   |   Updated: 6/17/2026   |   Inventor(s): Xiao Wang, Hanbing Cao
Keywords(s): Bioengineering, Cardiovascular, Gene Editing, Gene Therapy, Genetic Disorders, Orphan Disease
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Targeted Delivery of Noble Gases via Microbubbles for Organ-Specific Therapeutic and Imaging Applications
Phospholipid encapsulation enables enhanced ultrasound contrast and localized delivery of therapeutic gases following hypoxic-ischemic injury. Problem: Noble gases such as xenon (Xe), Argon (Ar) and helium (He) are known to provide cardioprotective and neuroprotective effects in hypoxic-ischemic injuries, traumatic brain injury and post-cardiac arrest....
Published: 6/16/2026   |   Updated: 6/16/2026   |   Inventor(s): Rajarshi Chattaraj, Daeyeon Lee, Chandra Sandy Sehgal, Daniel Hammer
Keywords(s): Cardiovascular, Imaging Agents, Soft Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Imaging, Technology Classifications > Therapeutics
Pervious Polymersomes For Antioxidant Enzyme Delivery
Pervious polymersomes encapsulate antioxidant agents while allowing reactive oxygen species to enter through diblock copolymer-defined channels. Problem: Reactive oxygen species and oxidative stress are associated with osteoarthritis development and myocardial injury. Direct use of antioxidant enzymes is challenging due to insufficient delivery systems....
Published: 6/11/2026   |   Updated: 6/11/2026   |   Inventor(s): Zhiliang Cheng, Andrew Tsourkas, Ling Qin
Keywords(s): Drug Delivery, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Materials, Technology Classifications > Therapeutics
Fast, On-Demand Manufacturing of Room Temperature-Stable RNA
A method enabling facile synthesis and purification of RNA in a stable format that does not require cold chain distribution. Problem: The cold storage conditions required in the distribution of RNA-based therapies presents a major roadblock toward expanding the utility of these medicines. RNA is susceptible to degradation in aqueous environment and...
Published: 6/11/2026   |   Updated: 6/11/2026   |   Inventor(s): Daeyeon Lee, Kathleen Stebe, Masoud Soroush, Dimitrios Papavassiliou
Keywords(s): Bioengineering, COVID-19, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Small Molecule mGlur5 Agonists for Remyelination in Multiple Sclerosis
​ Invention Summary: Multiple sclerosis (MS) is a debilitating autoimmune condition caused by an overactive immune system that destroys the myelin surrounding nerves cells. Symptoms of MS include pain, impaired coordination, vision loss, and overall weakness. Current treatment options work to suppress the immune system to slow progression of...
Published: 6/5/2026   |   Updated: 6/5/2026   |   Inventor(s): Hiroko Nobuta, Jacques Roberge, Cheryl Dreyfus, Yangyang Huang, Pingyue Pan
Keywords(s):  
Category(s): Technology Classifications > CNS Disorder, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
RNA-Aptamer-Mediated CRISPR Base Editing Platform for Agriculture License
​ Description of the base editing (BE) platform and proof of principle in prokaryotic. (A) Components of the platform. (B) Schematic of the modular complex at the target sequence. Collantes, J C et al. The CRISPR journal (2021). Invention Summary: The CRISPR/Cas system has become a foundational technology for precision genome engineering...
Published: 6/5/2026   |   Updated: 6/5/2026   |   Inventor(s): Shengkan (Victor) Jin, Juan-Carlos Collantes
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
LNP-Enabled Intracellular Delivery of Recombinant bioPROTACs
Recombinant fusion bioPROTACs are combined with cationic delivery agents and lipid formulations to enable cytosolic entry and on-demand intracellular degradation of target proteins. Tech Title: Technology: Technology: The core construct is a recombinant fusion protein comprising an E3 ubiquitin ligase domain, a small protein binding scaffold, and an...
Published: 6/9/2026   |   Updated: 5/29/2026   |   Inventor(s): Andrew Tsourkas, Alexander Chan
Keywords(s): Protein/Peptide (Non-Antibody), Soft Materials
Category(s): Technology Classifications > Therapeutics
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