Search Results - technology+classifications+%3e+therapeutics

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Increasing Efficiency of Anti-Tumor Immune Checkpoint Blockade Therapy by Manipulating Tumor-Associated Macrophages
A method to manipulate tumor-associated macrophages by targeting the mitochondrial electron transport chain, improving the efficacy of immune checkpoint blockade cancer therapies. Problem: Many cancer therapeutics work by activating the immune system to attack a tumor. These drugs, known as immune checkpoint blockade (ICB) therapies, commonly fail because...
Published: 5/13/2026   |   Updated: 5/13/2026   |   Inventor(s): Jorge Henao-Mejia, Megan Clark
Keywords(s): Drug Target, Immunology, Oncology
Category(s): Technology Classifications > Therapeutics
Highly Efficient Approach for Developing Biocompatible and Potent Lipid Nanoparticles
Enhancing the biocompatibility and potency of lipid nanoparticles (LNPs) by refining the structure of ionizable lipids through an iterative method. Problem: Ionizable lipids play a crucial role in determining the potency and biocompatibility of LNPs. Current approaches, medicinal chemistry, and combinatorial chemistry, each have limitations. Medicinal...
Published: 5/8/2026   |   Updated: 5/8/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Rohan Palanki
Keywords(s): Bioengineering, Drug Delivery, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Precise, Efficient Delivery of mRNA Medicine to the Placenta
Using tiny lipid nanoparticles (LNPs) to improve mRNA medicine delivery and uptake in the placenta for healthier pregnancies Problem: The placenta is an important biological barrier that connects the mother and fetus while keeping their blood supplies separate, enabling nutrient and oxygen delivery and waste removal for healthy development. Abnormal...
Published: 5/8/2026   |   Updated: 5/8/2026   |   Inventor(s): Michael Mitchell, Hannah Safford, Kelsey Swingle, Hannah Geisler
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Immunotherapy, Women's Health
Category(s): Technology Classifications > Therapeutics
An All-In-One “Swiss Army Knife” Tool To Edit Genes And Regulate Their Expression Without Off-Target Effects And Toxicity
A flexible toolkit for human gene editing, activation, and repression that can be applied in orthogonally and in various disease models. Problem: There is increasing demand for technologies that can simultaneously edit the genome and regulate the transcriptome without relying on toxic double-stranded breaks. Currently, treating complex diseases such...
Published: 5/5/2026   |   Updated: 5/5/2026   |   Inventor(s): Xue Sherry Gao, Tyler Daniel, Hongzhi Zeng, Qichen Yuan
Keywords(s): Bioengineering, Cell Therapy, Gene Editing, Genetic Disorders, Neurodegenerative Diseases, Obesity Metabolic Disease and Diabetes, Oncology, Orphan Disease, Pulmonary
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Interoceptomimetics: Dietary Supplements to Enhance Exercise Motivation and Performance
Enhancing exercise performance by modulating the activity of motivation-generating brain regions via stimulation of cannabinoid (CB1) receptors of the enteric nervous system. Problem: An increase in sedentary lifestyles driven by the modernization of society has led to a surge in several metabolic and neurological diseases worldwide. Although exercise...
Published: 4/30/2026   |   Updated: 4/30/2026   |   Inventor(s): Christoph Thaiss, John Nicholas Betley
Keywords(s): Aging, Cardiovascular, Healthcare IT, Microbiome, Neurology, Obesity Metabolic Disease and Diabetes, Regenerative Medicine, Small Molecule
Category(s): Technology Classifications > Food Science and Nutrition, Technology Classifications > Therapeutics
Benzofuranoindoline-Containing Fungal RiPP-Derived Anticancer Compounds
Benzofuranoindoline-containing fungal RiPP-derived compounds and analogs, plus pharmaceutical compositions, and administration methods for treating cancers, including leukemia. Problem: The disclosure targets diseases and disorders where new therapeutic compounds are needed, including cancers such as leukemia. Fungal ribosomally synthesized and post-translationally...
Published: 4/16/2026   |   Updated: 4/16/2026   |   Inventor(s): Xue Sherry Gao, Hans Renata, Qiuyue Nie
Keywords(s): Oncology, Small Molecule
Category(s): Technology Classifications > Therapeutics
Pharmacological Treatment for Sleep Disorders Improving Sleep Quality & Architecture
Targeting Heat Shock Factor 1 (HSF1) via gene therapy or using pharmacological compounds targeting HSF1 (e.g. geranylgeranylacetone or macrocyclic peptides) can increase sleep stability, promote deeper sleep, reduce sleep fragmentation, and improve recovery from sleep loss. Problem: Millions of people worldwide suffer from disrupted sleep, whether due...
Published: 4/16/2026   |   Updated: 4/14/2026   |   Inventor(s): Akhilesh Basi Reddy, Shintaro Yamazaki
Keywords(s): Aging, Drug Target, Gene Therapy, Neurodegenerative Diseases, Protein/Peptide (Non-Antibody), Small Molecule, Women's Health
Category(s): Technology Classifications > Therapeutics
Selective Receptor Modulators for Skin Depigmentation
Small-molecule compositions modulate non-canonical sex steroid receptors to decrease, prevent, or reverse skin pigmentation gain in mammalian subjects. Problem: Skin hyperpigmentation can arise from pregnancy, hormones, inflammatory conditions, or skin injury. Existing approaches may not address receptor pathways that regulate melanocyte pigmentation....
Published: 4/6/2026   |   Updated: 4/6/2026   |   Inventor(s): Todd Ridky, Christopher Natale
Keywords(s): Dermatology, Small Molecule
Category(s): Technology Classifications > Therapeutics
Method for Enhancing Immunoregulatory Effect of Stem Cells
rong> ​ IL-17A promotes MSC-Mediated immunosupressive effect. Changes in cell proliferation as shown in microscopy Invention Summary: Autoimmune diseases occur when the immune system attacks the body’s tissue components. Mesenchymal stem/stromal cells (MSCs) have been used as treatment to many autoimmune disorders such as type 1 diabetes,...
Published: 4/21/2026   |   Updated: 2/20/2026   |   Inventor(s): Yufang Shi, Guangwen Ren, Liying Zhang
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
Methods for Treating, Ameliorating, and Preventing Nephropathy/Nephritis
Method for protecting against nephropathy/nephritis through topical administration of a vitamin D3 analog, producing systemic therapeutic effects potentially beneficial in protein-losing nephropathy, lupus nephritis, diabetic nephropathy, focal segmental glomerulosclerosis (FSGS), and genetic nephropathies. Problem: Protein-losing nephropathy, lupus...
Published: 2/20/2026   |   Updated: 2/19/2026   |   Inventor(s): Taku Kambayashi, Yuichi Yokoyama
Keywords(s): Immunology, Nephrology and Urology
Category(s): Technology Classifications > Therapeutics
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