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Safe and Highly Selective HDAC8 Inhibitors for Kidney Disease and Precision Therapies
HDAC8-targeting small molecules for kidney disease treatment with improved safety, selectivity, and therapeutic potential. Problem: Acute kidney injury (AKI) and focal segmental glomerulosclerosis (FSGS) affect millions of patients worldwide and can contribute to chronic kidney disease and end-stage renal failure, which only has a 5-year survival rate...
Published: 6/30/2026   |   Updated: 6/30/2026   |   Inventor(s): Donna Huryn, Neil Hukriede
Keywords(s): Drug Target, Nephrology and Urology, Small Molecule
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
clampFISH 2.0: Fast, Cost-Effective RNA Detection Using Potent Fluorescent Probes
Molecular diagnostic using clamping fluorescent probes to amplify RNA detection signal of single-cell assay Problem: The molecular diagnostics market is expected to reach $13 billion by 2024, including cancer detection, blood screening, histology assays, tests for transplant compatibility, and inherited and infectious diseases (The World Market for...
Published: 6/29/2026   |   Updated: 6/26/2026   |   Inventor(s): Arjun Raj, Ian Dardani, Benjamin Emert, Sara Rouhanifard
Keywords(s): Bioengineering, Infectious Disease, Nanotechnology, Oncology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Diagnostics
Durable cure for Pseudoxanthoma Elasticum: High-Efficiency, Precision-Targeted Gene Therapy
Lipid nanoparticles containing messenger RNA (mRNA-LNPs) encoding Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) base-editors that correct pseudoxanthoma elasticum-causing mutations. Problem: Pseudoxanthoma elasticum (PXE) is a genetic disorder affecting approximately 1 in 25,000 Americans. It is caused by loss-of-function mutations...
Published: 6/17/2026   |   Updated: 6/17/2026   |   Inventor(s): Xiao Wang, Hanbing Cao
Keywords(s): Bioengineering, Cardiovascular, Gene Editing, Gene Therapy, Genetic Disorders, Orphan Disease
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Image-Based Soft-Sensor Approach to Automate Microfluidic Control
Leveraging open-source AI platforms, this technology enables automated image-based detection, prediction, and control of microfluidic single bubble/droplet formation. Problem: Given the incorporation of microfluidic bubble/droplet generation in many applications of science and medicine, improving their high-quality throughout with minimal human intervention...
Published: 6/30/2026   |   Updated: 6/15/2026   |   Inventor(s): Daeyeon Lee, Owen Land, Warren Seider
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Imaging Agents, Microfluidics, Soft Materials, Software
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Diagnostics, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents, Technology Classifications > Robotics, Technology Classifications > Medical Devices
A Fast And Cost-Effective Method For Early Cancer Detection
A quick and inexpensive method to detect cancer early by exponentially amplifying rare and scarce cancer mutations. Problem: Early cancer detection is challenging due to the low levels of cancer-indicating mutant DNA compared to healthy, wild-type DNA. The background noise from the substantial amounts of healthy DNA overwhelms mutant signals. Some...
Published: 6/12/2026   |   Updated: 6/12/2026   |   Inventor(s): Haim Bau, Jinzhao Song, Junman Chen
Keywords(s): Bioengineering, Gene Editing, Gene Therapy, Oncology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents
Method to Make Crack-Free Carbon Structures While Avoiding Shrinkage and Deformation
A method to make micropatterned carbon structures with pre-designed size and shape, avoiding shrinkage and deformation. Problem: Pyrolysis is a chemical process that involves the thermal decomposition of materials at elevated temperatures in an inert atmosphere. Applying pyrolysis to polymer templates can be used to fabricate micropatterned carbon...
Published: 6/12/2026   |   Updated: 6/12/2026   |   Inventor(s): Tiancheng Wang, Kathleen Stebe, Daeyeon Lee, Raymond Gorte, Renjing Huang
Keywords(s): Electronic Materials, Nanotechnology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
A Solvent For The Extraction And Preservation Of mRNA At Room Temperature
A buffer that allows the extraction and long-term room temperature preservation of mRNA. Problem: mRNA is unstable in aqueous environments, so different formulations have been explored as water-free solvents for RNA. However, these solvents often contain toxic heavy metals, resulting in biological incompatibility. Additionally, current mRNA vaccines...
Published: 6/10/2026   |   Updated: 6/10/2026   |   Inventor(s): Daeyeon Lee, Kathleen Stebe, Hoang Dinh
Keywords(s): COVID-19, Infectious Disease, Platform Technology, Soft Materials
Category(s): Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Microfluidic Lung Chip For Development Modeling
A microfluidic lung chip applies controlled mechanical forces to hydrogel-embedded lung cells or organoids to model lung development in vitro. Problem: Developing lung tissues experiences dynamic mechanical forces during organogenesis. How these forces influence later-stage lung development remains poorly understood. Existing models have not adequately...
Published: 6/10/2026   |   Updated: 6/10/2026   |   Inventor(s): Sunghee Estelle Park, Barry Cooperman
Keywords(s): Bioengineering, Pulmonary
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents
A Tunable Nanostructured Surface for the Enhancement of Differential Magnetic Resonance Imaging (MRI)
A single metasurface to obtain enhanced images for various magnetic resonance nuclei and field. Problem: Conducting magnetic resonance imaging (MRI) at field strengths greater than 7T is difficult because the shortened radiofrequency (RF) wavelengths that are inherent to higher field strength systems cause interference that result in degraded image...
Published: 6/2/2026   |   Updated: 6/2/2026   |   Inventor(s): Paul Jacobs, Mark Elliott, Ravinder Reddy, Gabor Mizsei
Keywords(s): Electronic Materials, Platform Technology, Radiology
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents, Technology Classifications > Imaging, Technology Classifications > Materials
Cell-Free Translation Readthrough Assay System
A high-throughput cell-free assay system screens translation readthrough drugs using labeled reporter complexes and fluorescence-based measurements. Tech Title: Technology: Technology: The system includes a substrate with multiple regions, each containing a cell-free ribosome-dependent protein synthesis reporter complex. The reporter complex includes...
Published: 6/5/2026   |   Updated: 5/29/2026   |   Inventor(s): Barry Cooperman, Mikel Ghelfi
Keywords(s): Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
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