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Search Results - technology+classifications+%3e+gene+therapy
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Utilize lipid nanoparticle-based CRISPR/Cas9 genome editing to delete the Pfkp gene for the treatment of head and neck cancer
This technology introduces a novel lipid nanoparticle-based CRISPR/Cas9 system designed to target the Pfkp gene for the effective treatment of head and neck cancer. Background: Head and neck cancer continues to pose a significant clinical challenge due to its aggressive nature and poor patient prognosis. A primary contributing factor is the overexpression...
Published: 6/22/2026
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Updated: 6/21/2026
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Inventor(s):
Yamin Li
Keywords(s):
cancer
,
cancer therapy
,
lipids
,
nanoparticle
,
Technologies
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Gene Therapy
,
Technology Classifications > Therapeutics and Vaccines
Targeting Protein Phosphatase-5 in Cancer
This technology introduces a novel approach to cancer treatment by targeting Protein Phosphatase 5 (PP5) to regulate apoptosis and inhibit tumor growth, particularly in clear cell renal cell carcinoma (ccRCC). Background: Cancer cells often evade programmed cell death, allowing tumors to grow unchecked. In clear cell renal cell carcinoma, dysregulation...
Published: 6/22/2026
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Updated: 6/16/2026
|
Inventor(s):
Mehdi Mollapour
,
Gennady Bratslavsky
,
John Chisholm
,
Dimitra Bourboulia
,
Mark Woodford
Keywords(s):
cancer
,
cancer therapy
,
phosphorylation
,
Technologies
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Gene Therapy
Raman Spectroscopy for Probing Encapsulation of mRNA in Lipid Nanoparticles
This technology uses deep ultraviolet Raman spectroscopy and advanced data analysis to quickly and non-destructively measure how much mRNA is unencapsulated in lipid nanoparticles, improving quality control for mRNA vaccines and therapeutics without chemical labels. Background: Messenger RNA (mRNA) therapeutics, particularly those delivered via lipid...
Published: 6/12/2026
|
Updated: 6/11/2026
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Inventor(s):
Igor Lednev
,
Alexander Shekhtman
,
Sergei Reverdatto
,
Sila Jin
,
Young Mee Jung
Keywords(s):
mRNA
,
Raman spectroscopy
,
spectroscopy
,
statistical analysis
,
Technologies
,
therapeutics
,
vaccines
Category(s):
Campus > University at Albany
,
Technology Classifications > Gene Therapy
RNA-Aptamer-Mediated CRISPR Base Editing Platform for Agriculture License
Description of the base editing (BE) platform and proof of principle in prokaryotic. (A) Components of the platform. (B) Schematic of the modular complex at the target sequence. Collantes, J C et al. The CRISPR journal (2021). Invention Summary: The CRISPR/Cas system has become a foundational technology for precision genome engineering...
Published: 6/5/2026
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Updated: 6/5/2026
|
Inventor(s):
Shengkan (Victor) Jin
,
Juan-Carlos Collantes
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Research Tools
,
Technology Classifications > Therapeutics
,
Technology Classifications > Gene Therapy
Temporal Control of CRISPR-Cas9 using Bio-orthogonal Chemistry.
This technology enables precise, time-controlled activation or deactivation of CRISPR-Cas9 genome editing using biocompatible chemical reactions, reducing off-target effects and improving the safety and accuracy of gene editing for research and therapeutic applications. Background: Genome editing technologies, particularly CRISPR-Cas9, have revolutionized...
Published: 5/5/2026
|
Updated: 5/4/2026
|
Inventor(s):
Maksim Royzen
,
Bhoomika Pandit
Keywords(s):
biochemistry
,
CRISPR
,
Technologies
Category(s):
Campus > University at Albany
,
Technology Classifications > Gene Therapy
Chemogenetic Treatment for Neurodegenerative and Neuropsychiatric Disorders
yle> DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depression-like...
Published: 2/20/2026
|
Updated: 9/10/2025
|
Inventor(s):
Gary Aston-Jones
Keywords(s):
Category(s):
Technology Classifications > CNS Disorder
,
Technology Classifications > Gene Therapy
,
Technology Classifications > Therapeutics
Glycosylated RNA in Exosome Extracellular Vesicles
Overview of experimental approach used to demonstrate exosome-mediated intercellular transfer of glycoRNAs Invention Summary: Exosomes play a significant role in diverse cellular functions and responses. These structures are believed to furnish cells with a signaling mechanism facilitated by the cargo enclosed within the exosome. This cargo...
Published: 2/20/2026
|
Updated: 5/28/2025
|
Inventor(s):
Megerditch Kiledjian
,
Sunny Sharma
,
Xinfu Jiao
Keywords(s):
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Gene Therapy
Virus-Like Particles for mRNA Delivery
Virus-like particles have been engineered for drug delivery, gene editing applications, mRNA delivery and overcoming barriers in mouse lungs. Background: Recent biomedical research has shown increased interest in the use of virus-like particles as a drug delivery vehicle. Current viral vectors have been shown to cause adverse immunological responses,...
Published: 6/19/2026
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Updated: 5/19/2025
|
Inventor(s):
Sriram Neelamegham
,
Qi Yang
Keywords(s):
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Biological Materials
,
Technology Classifications > Drug Delivery
,
Technology Classifications > Healthcare
,
Technology Classifications > Gene Therapy
,
Technology Classifications > Materials and Chemicals
,
Technology Classifications > Research Tools and Reagents
,
Technology Classifications > Screens and Assays
Gsx1 GENE THERAPY TO TREAT SPINAL CORD INJURY
Gsx1 treatment promotes recovery of locomotion function in injured mice. Invention Summary: Spinal cord injury (SCI) can lead to permanent disruption of nervous system function. There is no effective treatment for promoting recovery of motor function after SCI currently available on the market. Previous research on SCI treatment focused on...
Published: 2/20/2026
|
Updated: 1/11/2023
|
Inventor(s):
Li Cai
,
Misaal Patel
,
Lisa Lyu
Keywords(s):
Spinal Cord
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
,
Technology Classifications > Gene Therapy
,
Technology Classifications > CNS Disorder
RNA-Aptamer-Mediated Base Editing System for Agriculture
Invention Summary: The CRISPR/Cas system is a powerful tool for precision genetic engineering in organisms including plants. However, the conventional CRISPR technology depends on DSBs which may lead to undesired genetic events such as off-target insertions, deletions, and chromosomal translocations. The Base Editing technology...
Published: 3/6/2026
|
Updated: 11/30/2022
|
Inventor(s):
Shengkan (Victor) Jin
,
Juan-Carlos Collantes
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Gene Therapy
,
Technology Classifications > Therapeutics
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