Search Results - crispr

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Temporal Control of CRISPR-Cas9 using Bio-orthogonal Chemistry.
This technology enables precise, time-controlled activation or deactivation of CRISPR-Cas9 genome editing using biocompatible chemical reactions, reducing off-target effects and improving the safety and accuracy of gene editing for research and therapeutic applications. Background: Genome editing technologies, particularly CRISPR-Cas9, have revolutionized...
Published: 5/5/2026   |   Updated: 5/4/2026   |   Inventor(s): Maksim Royzen, Bhoomika Pandit
Keywords(s): biochemistry, CRISPR, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Gene Therapy
ImmunoMag-CRISPR lateral flow assay
RPI ID: 2024-015-301 Innovation Summary: This technology introduces a point-of-care diagnostic system for urinary biomarkers using ultrasensitive ImmunoMag-CRISPR lateral flow assays. It combines magnetic bead-based sample preparation with CRISPR-based detection for enhanced sensitivity and specificity. The system is portable and designed for rapid,...
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Inseon Lee, Peter Heeger, Jonathan Dordick, Seok-Joon Kwon
Keywords(s): Cas12a, CRISPR, Immunoassay, Kidney transplant rejection, lateral flow assay, Urinary biomarkers
Category(s): Biotechnology and the Life Sciences
DsDNA-templated Substrates as Fluorescent Probes for CRISPR-Cas12a-based Diagnostics
New design for CRISPR-based fluorescent probes improves disease diagnostics and sensing. Background: Scientists use the naturally occurring CRISPR-Cas12a gene editing system as a valuable tool for disease diagnostics. When Cas12a finds its target -- a sequence of double-stranded DNA -- it cuts it. In the process, it also cuts other nearby DNAs. Scientists...
Published: 1/30/2026   |   Updated: 10/24/2025   |   Inventor(s): Mehmet Yigit, Christopher Smith
Keywords(s): agriculture, biotechnology, Cas12a, Cas12a, CRISPR, CRISPR, detection, detection, DNA, DNA, fluorescence, fluorescence, RNA, RNA, sensor, sensor
Category(s): Technology Classifications > Diagnostics, Campus > University at Albany
DsDNA-templated Substrates as Fluorescent Probes for CRISPR-Cas12a-based Diagnostics
New design for CRISPR-based fluorescent probes improves disease diagnostics and sensing. Background: Scientists use the naturally occurring CRISPR-Cas12a gene editing system as a valuable tool for disease diagnostics. When Cas12a finds its target -- a sequence of double-stranded DNA -- it cuts it. In the process, it also cuts other nearby DNAs. Scientists...
Published: 1/30/2026   |   Updated: 10/24/2025   |   Inventor(s): Mehmet Yigit, Christopher Smith
Keywords(s): agriculture, biotechnology, Cas12a, Cas12a, CRISPR, CRISPR, detection, detection, DNA, DNA, fluorescence, fluorescence, RNA, RNA, sensor, sensor
Category(s): Technology Classifications > Diagnostics, Campus > University at Albany
DELIVERY OF CRISPR COMPONENTS
Researchers at UC Berkeley have developed novel strategies for the delivery of CRISPR gene editing components. While CRISPR-based gene editing holds great promise for treating genetic diseases, it often involves DNA breaks or base changes that can cause off-target effects, cell damage, or unpredictable outcomes. Additionally, these changes are often...
Published: 4/15/2026   |   Updated: 10/23/2025   |   Inventor(s): James Nunez, Da Xu, Swen Besselink
Keywords(s): CRISPR, Epigenetics
Category(s): Technology Classifications > Biology
CRISPR-associated Protein for Treating Neurological Diseases
Blocks Transcription of Expanded Microsatellite Repeats to Treat Muscle Degenerating DiseasesThis therapeutic precisely targets microsatellite repeats in the DNA sequence and blocks the transcription of a genetic mutation, called hexanucleotide repeat expansion, providing therapy for a variety of neurological and muscular degenerative diseases. The...
Published: 1/20/2026   |   Updated: 5/13/2025   |   Inventor(s): Tanvi Saxena, Belinda Pinto, Eric Wang
Keywords(s): CRISPR, Neurological Diseases, Transcription
Category(s): Technology Classifications > Human Health Care > Therapeutics
Synthetic Exosomes (SE) for CNS Delivery of CRISPR for Gene Editing in Brain Disorders (UCLA Case No. 2021-363)
UCLA researchers from the Department of Neurology have developed synthetic exosomes, a novel delivery technology capable of transporting gene-editing tools and therapeutics across the blood-brain barrier, with successful applications in repairing Alzheimer’s-related mutations and delivering proteins, antibodies, and drugs. BACKGROUND: The emergence...
Published: 7/17/2025   |   Updated: 2/18/2025   |   Inventor(s): Varghese John
Keywords(s): Alzheimers disease, CRISPR, delivery system, exosome, Nanotechnology, nanovesicles, synthetic biology
Category(s): Life Science Research Tools > Microfluidics And Mems, Materials > Nanotechnology, Platforms > Drug Delivery, Therapeutics > Gene Therapy And Editing, Therapeutics > CNS and Neurology
Identification of a Factor That Rescues Dysregulated Endocytosis in Cultured Human Hematopoietic Stem Cells (UCLA Case No. 2023-051)
UCLA researchers in the Departments of Molecular, Cell & Developmental Biology have developed a novel method to enhance the function of hematopoietic stem cells (HSCs) to improve the transplantability of ex vivo expanded human HSCs in clinical settings. BACKGROUND: Hematopoietic stem cells (HSCs), present in blood and bone marrow, can form mature...
Published: 12/2/2025   |   Updated: 10/3/2024   |   Inventor(s): Hanna Mikkola, Julia Aguade Gorgorio
Keywords(s): bone marrow, bone marrow transplants, CRISPR, endocytosis, engraftment, environmental sensing, hematopoietic stem cells, leukemia, MLLT3, MYCT1, transplantability
Category(s): Therapeutics > Hematology, Life Science Research Tools, Therapeutics > Stem Cells And Regenerative Medicine
Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)
UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-CRISPR mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive brain tumors originating...
Published: 10/7/2025   |   Updated: 9/20/2023   |   Inventor(s): Serendipity Rinonos, Albert Lai
Keywords(s): Brain, Cancer, Cancer stem cells, Chemotherapy, Combination therapy, CRISPR, CRISPR-Cas9, Epigenetics, GBM, Glioma
Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology
­ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING
­ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING Researchers at Stanford have developed a new methodology for image processing that allows for high-throughput characterization of organoid phenotypes. Organoids represent a major step forward in in vitro research studies into a myriad of disease states. 3D organoid models possess key advantages...
Published: 9/14/2023   |   Updated: 9/14/2023   |   Inventor(s): Polly Fordyce, Christina Curtis, Alexandera Sockell, Wing Wong
Keywords(s): CRISPR, High-Throughput, Imaging, Organoid
Category(s): Technology Classifications > Biology
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