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Safe and Highly Selective HDAC8 Inhibitors for Kidney Disease and Precision Therapies
HDAC8-targeting small molecules for kidney disease treatment with improved safety, selectivity, and therapeutic potential. Problem: Acute kidney injury (AKI) and focal segmental glomerulosclerosis (FSGS) affect millions of patients worldwide and can contribute to chronic kidney disease and end-stage renal failure, which only has a 5-year survival rate...
Published: 6/30/2026   |   Updated: 6/30/2026   |   Inventor(s): Donna Huryn, Neil Hukriede
Keywords(s): Drug Target, Nephrology and Urology, Small Molecule
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Mechagenic Energy System: An “Electrochemical Stomach” for Continuously Powering Robots and Aircraft
An electrochemical system for continuously powering robots through the ingestion of energy-dense organic molecules, utilizing a new electrolyte that enables the maximization of material performance. This system also provides a method for recycling and reusing the materials used in the stomach. Problem: The electrification of existing battery-powered...
Published: 6/26/2026   |   Updated: 6/26/2026   |   Inventor(s): James Pikul, Yue Gao
Keywords(s): Nanotechnology, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Energy, Technology Classifications > Materials, Technology Classifications > Robotics
A Low Swelling, Pressure-Free Method for Producing of Lithium Metal Anodes
A 3D gyroid polymer microlattice enables new type of lithium-metal batteries by reducing non-unifrom Li etching in lithium metal anodes. Problem: Lithium (Li) metal pouch cells represent the future of lithium-metal batteries due to their thinness and high capacity. But one caveat has held back these cells: significant volume increases after cycling...
Published: 6/26/2026   |   Updated: 6/26/2026   |   Inventor(s): James Pikul, Yue Gao
Keywords(s): Electronic Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Energy, Technology Classifications > Materials
Self-Assembling Nanolattices with Superior Tensile Strength That are Scalable and Free of Cracks
Elimination of cracks in self-assembly using a wet template and positively charged particles produces relatively large-area nanolattices with enhanced tensile strength. Problem: Nanolattice fabrication is currently dominated by 3D-printing that employs 2-photon polymerization. However, structures made in this fashion feature imperfections which lead...
Published: 6/25/2026   |   Updated: 6/25/2026   |   Inventor(s): James Pikul, Zhimin Jiang, David Issadore, Andrew Lin
Keywords(s): Nanotechnology, Optics & Photonics 
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Energy
Small-Molecule Therapeutic for Stabilizing HIV-1 Envelope Proteins to Increase Immune Response
Small-molecule inhibitor that prolongs exposure of HIV-1 to broadly neutralizing antibodies to suppress viral entry and infection Problem: The human immunodeficiency virus (HIV-1) infects human cells through binding of its envelope proteins to surface-expressed CD4 and CCR5 receptors. Broadly neutralizing antibodies can recognize the native, functional...
Published: 6/25/2026   |   Updated: 6/25/2026   |   Inventor(s): Amos Smith, Althea Lang, Joseph Sodroski
Keywords(s): Drug Target, HIV/AIDS, Immunology, Infectious Disease
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis
Inexpensive, Light-Activated Method for Dehydrogenation of Polyethylene
A photocatalyzed polyethene dehydrogenation process that utilizes inexpensive and commercially available reagents for polyethylene transformations. Problem: Industry produces 258 million tons of polymer annually. Polyolefins, including polyethylene, account for 60% of this total. Established polymerization routes control the chain architecture (i.e.,...
Published: 6/23/2026   |   Updated: 6/23/2026   |   Inventor(s): Marisa Kozlowski, Karen Winey, Ikechukwu Ogbu, Hoda Shokrollahzadeh Behbahani, Cassandra Vu
Keywords(s): Platform Technology, Soft Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Agriculture & Environment
Fast Method to Make High Surface Area Crystalline Nanoparticles for Catalysis
A heating treatment method to make crystalline nanoparticles with a high surface-area-to-volume ratio for catalytic applications. Problem: Catalysis, the acceleration of a chemical reaction by adding a catalyst material, plays a major role in many emerging technologies, with applications from petroleum refinement to carbon dioxide reduction. One powerful...
Published: 6/16/2026   |   Updated: 6/16/2026   |   Inventor(s): Deep Jariwala, Eric Stach, Pawan Kumar
Keywords(s): Electronic Materials, Nanotechnology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials
Targeted Delivery of Noble Gases via Microbubbles for Organ-Specific Therapeutic and Imaging Applications
Phospholipid encapsulation enables enhanced ultrasound contrast and localized delivery of therapeutic gases following hypoxic-ischemic injury. Problem: Noble gases such as xenon (Xe), Argon (Ar) and helium (He) are known to provide cardioprotective and neuroprotective effects in hypoxic-ischemic injuries, traumatic brain injury and post-cardiac arrest....
Published: 6/16/2026   |   Updated: 6/16/2026   |   Inventor(s): Rajarshi Chattaraj, Daeyeon Lee, Chandra Sandy Sehgal, Daniel Hammer
Keywords(s): Cardiovascular, Imaging Agents, Soft Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Imaging, Technology Classifications > Therapeutics
Large-Scale Continuous Manufacturing of Micro and Nano-Scale Surface Wrinkles
Surface wrinkles able to control material properties of polymer films are produced across (a) large-areas by a combination of oxygen plasma treatment and sequential rolling. (b)-(c) wrinkles span the nanometer to micrometer scale, as demonstrated with scanning electron micrograph Scalable manufacturing technique to produce micro or nano-scale surface...
Published: 6/16/2026   |   Updated: 6/16/2026   |   Inventor(s): Daeyeon Lee, Kathleen Stebe, Shu Yang, Xu Zhang
Keywords(s):  
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials
Wafer-Scale Growth of Two-Dimensional, Phase-Pure Indium(II) Selenide (InSe) and Its Applications in Electronics
Synthesis of epitaxial two-dimensional Indium(II) selenide (InSe) by metal-organic chemical vapor deposition (MOCVD) over 2-inch wafers and its applications in electronics. Problem: The current methods have not demonstrated the large-area synthesis of 2D InSe due to the complexity of the binary In-Se system and the difficulties in promoting lateral...
Published: 6/30/2026   |   Updated: 6/12/2026   |   Inventor(s): Deep Jariwala, Roy Olsson, Seunguk Song
Keywords(s): Electronic Materials, Nanotechnology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Hardware & Components, Technology Classifications > Materials
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