Search Results - oleh+taratula

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Next-Generation ROS Nanotherapy for Targeted Cancer Destruction
Produces complementary reactive oxygen species in tumors, enabling efficient tumor killing without external activation Background Conventional cancer treatments such as surgery, chemotherapy, and radiotherapy are often invasive, non-specific, and associated with systemic toxicity and long-term side effects. Emerging nanomedicine approaches improve...
Published: 5/8/2026   |   Updated: 5/8/2026   |   Inventor(s): Oleh Taratula, Olena Taratula, Chao Wang
Keywords(s): breast cancer, chemodynamic therapy (CDT), Fenton reaction, ferrous, immuno-oncology, metal-organic framework (MOF), nanomedicine, oncology therapeutics, porphyrin, reactive oxygen species (ROS), Russell mechanism, solid tumor, tumor microenvironment, tumor suppression, tumor targeting, tumour microenvironment
Category(s): Therapeutics
Targeted Nanocarriers for Brain Inflammation and Cancer Cachexia
Nanocarriers deliver anti-inflammatory therapeutics across the blood-brain barrier to activated microglia Background Delivering therapeutics to the brain remains a major drug-development challenge because the blood-brain barrier restricts systemic agents from reaching therapeutically relevant concentrations in the central nervous system. This barrier...
Published: 5/7/2026   |   Updated: 5/7/2026   |   Inventor(s): Oleh Taratula, Olena Taratula, Yoon Tae Goo
Keywords(s): anti-inflammatory, Anti-inflammatory drugs, biodegradable, biodistribution, blood-brain barrier, brain delivery, brain inflammation, CNS drug delivery, cytokine expression, Drug Delivery, Drug Development, glutathione, immune cell, immunohistochemistry, irak4 inhibitor, lipopolysaccharides, microglia, mouse model, nanocarrier, nanocarriers, nanomedicine, neuroinflammation, pancreatic cancer, pharmaceuticals, pharmacokinetics, preservation, pro-inflammatory cytokine, small molecules, water-soluble, weight maintenance
Category(s): Therapeutics
Next-Generation Photothermal Nanoagent for Safe Systemic Tumor Ablation
A resonance energy transfer (RET)–engineered nanoplatform enabling complete tumor ablation using near-infrared irradiation Background Photothermal therapy (PTT) uses NIR light to generate localized tumor heating. However, many systems require elevated laser power densities to achieve therapeutic temperatures, limiting translational feasibility....
Published: 4/3/2026   |   Updated: 4/3/2026   |   Inventor(s): Oleh Taratula, Olena Taratula, Prem Singh
Keywords(s):  
Category(s): Therapeutics, Medical Devices
Enhancing Methotrexate Efficacy for Ectopic Pregnancy Treatment
Methotrexate (MTX) loaded polymersomes are used to preferentially deliver MTX to sites of ectopic pregnancy Background Ectopic pregnancy, abnormal pregnancy implantation at sites other than in the uterine cavity, leads to internal bleeding if not identified and treated in a timely manner, and is a major cause of maternal morbidity and mortality....
Published: 1/12/2026   |   Updated: 9/5/2024   |   Inventor(s): Olena Taratula, Oleh Taratula, Maureen Baldwin, Leslie Myatt, Babak Mamnoon
Keywords(s):  
Category(s): Therapeutics
Nanocarriers for Systemic Delivery of IRAK4 Inhibitors to Inflamed Tissues
A nanocarrier system to effectively deliver anti-inflammatory drugs and improve the treatment of inflammatory diseases Background The inflammatory response is the body’s natural defense mechanism against infection and injury. In certain instances, however, persistent and uncontrolled inflammation becomes detrimental and contributes to the...
Published: 8/4/2025   |   Updated: 5/30/2024   |   Inventor(s): Oleh Taratula, Olena Taratula, Youngrong Park, Daniel Marks, Tetiana Korzun
Keywords(s):  
Category(s): Nanoscience & Microtechnologies
Nanotechnology-based Method for Treatment of Primary Ovarian Cancer and Prevention of Metastases
Two-in-one: Combined nanocarrier based targeted chemo and gene therapy 1. Cellular penetration of naked siRNA (green) and siRNA delivered by nanocarrier (red), 2. Treatment of mice bearing metastatic ovarian cancer. a. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (before treatment), b. Mice bearing xenografts of human...
Published: 2/20/2026   |   Updated: 11/13/2020   |   Inventor(s): Tamara Minko, Olga Garbuzenko, Oleh Taratula, Lorna Rodriguez-Rust, Vatsal Shah
Keywords(s): Anti-cancer, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
Treatment for Muscle Atrophy and for Enhancing Muscle Growth
An mRNA based therapeutic that provides for increased hepatic production of follistatin Background Muscle atrophy is a detrimental and often severely debilitating disease state whose etiology lies within a myriad of disease states ranging from AIDS, sepsis, cardiac failure, muscular dystrophies, cancer, and the natural process of aging. The extent...
Published: 8/4/2025   |   Updated: 2/1/2018   |   Inventor(s): Oleh Taratula, Canan Schumann, Olena Taratula, Adam Alani
Keywords(s): atrophy, growth, mRNA carrier, mRNA delivery, muscle, Muscular Dystrophy, wasting
Category(s): Therapeutics