Search Results - tumor+microenvironment

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Next-Generation ROS Nanotherapy for Targeted Cancer Destruction
Produces complementary reactive oxygen species in tumors, enabling efficient tumor killing without external activation Background Conventional cancer treatments such as surgery, chemotherapy, and radiotherapy are often invasive, non-specific, and associated with systemic toxicity and long-term side effects. Emerging nanomedicine approaches improve...
Published: 5/8/2026   |   Updated: 5/8/2026   |   Inventor(s): Oleh Taratula, Olena Taratula, Chao Wang
Keywords(s): breast cancer, chemodynamic therapy (CDT), Fenton reaction, ferrous, immuno-oncology, metal-organic framework (MOF), nanomedicine, oncology therapeutics, porphyrin, reactive oxygen species (ROS), Russell mechanism, solid tumor, tumor microenvironment, tumor suppression, tumor targeting, tumour microenvironment
Category(s): Therapeutics
Engineered T Cells Capable of Simultaneous Tumor Targeting and Alteration of Tumor Microenvironment Through Vasculature Normalization (UCLA Case No. 2023-264)
UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have built a series of chimeric antigen receptor (CAR)-T cells that target different antigens and secrete different anti-angiogenic proteins. Additionally, researchers also constructed bispecific CARs that respond to tumor antigen and pro-angiogenic molecules. BACKGROUND:...
Published: 7/31/2025   |   Updated: 6/27/2024   |   Inventor(s): Yvonne Chen
Keywords(s): Cancer, Cancer Immunotherapy, CAR-T cell therapy, immunosuppression, Immunosuppressive Drug, Immunotherapy, solid tumors, Tumor microenvironment, tumor vasculature, VEGF
Category(s): Therapeutics > Oncology
Fully Human Antibodies and Antibody Drug Conjugates Targeting Tumor Endothelial Marker 8 (TEM8) for the Treatment of Cancer
Abstract: The tumor microenvironment consists of a heterogenous population of cells which includes tumor cells and tumor-associated stroma cells (TASCs). The TASCs promote tumor angiogenesis, proliferation, invasion and metastasis. Because stroma cells are found in both healthy and cancerous tissue, targeting the tumor stroma has been difficult due...
Published: 4/22/2025   |   Updated: 8/2/2023   |   Inventor(s): Dimiter Dimitrov, Zhongyu Zhu, Brad St. Croix, Enrique Zudaire Ubani, Saurabh Saha, Xaioyan Zhang, Dean Welsch, Gary Decrescenzo
Keywords(s): Antibody Drug Conjugate (ADC), ANTXR1, TEM8, Tumor Microenvironment, Tumor Stroma
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics