Search Results - pharmaceuticals

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Targeted Nanocarriers for Brain Inflammation and Cancer Cachexia

Nanocarriers deliver anti-inflammatory therapeutics across the blood-brain barrier to activated microglia Background Delivering therapeutics to the brain remains a major drug-development challenge because the blood-brain barrier restricts systemic agents from reaching therapeutically relevant concentrations in the central nervous system. This barrier...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s): Oleh Taratula, Olena Taratula, Yoon Tae Goo

Keywords(s): anti-inflammatory, Anti-inflammatory drugs, biodegradable, biodistribution, blood-brain barrier, brain delivery, brain inflammation, CNS drug delivery, cytokine expression, Drug Delivery, Drug Development, glutathione, immune cell, immunohistochemistry, irak4 inhibitor, lipopolysaccharides, microglia, mouse model, nanocarrier, nanocarriers, nanomedicine, neuroinflammation, pancreatic cancer, pharmaceuticals, pharmacokinetics, preservation, pro-inflammatory cytokine, small molecules, water-soluble, weight maintenance

Category(s): Therapeutics

Exogenous Acetate Formulations for Treating Alcohol Use Disorder and Withdrawal

Advantages Mechanistic Innovation: stabilizes brain energy metabolism and modulates adenosine signaling mechanisms not targeted by current addiction therapies. Targeted Brain Delivery: formulations enable effective acetate transport across the blood-brain barrier, (BBB) Controlled and sustained release Versatile Administration Routes: compatible...

Published: 5/11/2026 | Updated: 9/30/2025 | Inventor(s): Dominic D'Agostino

Keywords(s): Neuroscience, Pharmaceuticals

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience

Methionine Sulfoxide Reductase A (MsrA) Gene Therapy for Retinal Degeneration

Advantaages Targeted Protection Against Oxidative Stress Dual-Vector Delivery System (AAV and Lenti) Simple and scalable plasmid design for efficient production Suitable for major ophthalmology indications: Age-related macular degeneration (AMD), Retinitis pigmentosa, other oxidative stress-related retinal degenerations Summary Oxidative stress...

Published: 5/11/2026 | Updated: 8/18/2025 | Inventor(s): Manas Biswal

Keywords(s): Ophthalmology, Pharmaceuticals

Category(s): Technology Classifications, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals

High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases

Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...

Published: 5/11/2026 | Updated: 5/27/2025 | Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An

Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment

Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals

Semicarbazones Synthesis Using Ethyl Lactate or Dimethyl Isosorbide as a Green Solvent

A novel method for synthesizing semicarbazones without toxic solvents that is both faster and produces higher yields. Background: Semicarbazones comprise an important structural class of compounds with valuable and diverse biological properties. They are used to synthesize various heterocyclic compounds, which have wide ranges of pharmacological activities...

Published: 1/30/2026 | Updated: 5/13/2025 | Inventor(s): Eric Helms, Jacqueline Bennett

Keywords(s): chemicals, environment, environmental chemistry, organic chemistry, pharmaceuticals, polymers, TAF

Category(s): Technology Classifications > Materials and Chemicals, Campus > SUNY Geneseo, Campus > SUNY Oneonta

Novel Combination Treatment for Glioblastoma

Advantages: Temozolomide (TMZ), Cannabidiol (CBD), and CCR6/CCL20 inhibitors work together to overcome Glioblastoma resistance and enhance efficacy Targeted CCL20/CCR6 inhibition blocks survival pathways in glioblastoma, reducing resistance and relapse while improving outcomes Enhances CD8+ T cells and rewires immunity, offering powerful, lasting...

Published: 5/11/2026 | Updated: 4/30/2025 | Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Ryan Green, Karthick Mayilsamy

Keywords(s): Cancer Treatment, Pharmaceuticals

Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical

Colorectal Cancer Gene Expression Signature as a Predictor for Therapy Outcomes

Advantages: Novel biomarker development: Unique 10-gene signatures distinguish the contributions of tumor epithelium (EPI) & tumor microenvironment (TME) in colorectal cancer (CRC) Clinical Relevance: EPIS signature predicts better progression-free survival in cetuximab-treated metastatic CRC patients; TMES correlates with worse survival outcomes Enhanced...

Published: 5/11/2026 | Updated: 2/12/2025 | Inventor(s): Timothy Yeatman, Mingli Yang

Keywords(s): Cancer Treatment, Pharmaceuticals

Category(s): Technology Classifications > Cancer, Technology Classifications > Medical, Technology Classifications > Chemistry

Anti-Thrombin Nanoparticles and Therapeutics to Treat Necrotizing Enterocolitis

Advantages: Bivalirudin-tagged nanoparticles bind and neutralize nascent thrombin in clots, minimizing systemic anticoagulant effects Anti-thrombin nanoparticle confines its anticoagulant activity to sites of clot formation, limiting excessive systemic coagulation inhibition Dual therapeutic and diagnostic potential allows clinicians to treat NEC...

Published: 5/11/2026 | Updated: 2/5/2025 | Inventor(s): Akhil Maheshwari, Samuel Wickline, Koppenruncholan Namachivayam, Hua Pan

Keywords(s): Gastrointestinal / Digestive Health, Pharmaceuticals

Category(s): Technology Classifications > Medical > Pharmaceuticals

4-Aminopyridine to Enhance Arousal

We anticipate that this topical treatment will increase genital sensitivity in women, facilitating sexual arousal and helping treat sexual dysfunction. Background: As the population ages, there has been increased focus around sexual dysfunction as a medical issue. This has resulted in a number of successful treatments that ameliorate sexual dysfunction...

Published: 3/9/2026 | Updated: 1/24/2025 | Inventor(s): Steven Rothman

Keywords(s): molecular pharmacology, multiple sclerosis, pharmaceuticals, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

SLURP1 is a Novel Therapeutic Target for Ocular Surface Inflammatory Disorders

Advantages: Identification and validation of SLURP1 as a therapeutic target for treating ocular therapies SLURP1 enhances antioxidant defenses SLURP1 counteracts TGF-β-induced EMT in corneal epithelial cells Potential for Formulating eye care products with SLURP1 to mitigate oxidative stress and maintain corneal epithelial homeostasis (e.g....

Published: 5/11/2026 | Updated: 1/24/2025 | Inventor(s): Shivalingappa Swamynathan, Sudha Swamynathan, Satinder Kaur

Keywords(s): Ophthalmology, Pharmaceuticals

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology

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