Search Results - neurodegeneration

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Spectroscopic Method for Diagnostics of Alzheimer's Disease
This technology provides a non-invasive, spectroscopic method using Raman spectroscopy to diagnose and monitor Alzheimer’s disease by analyzing biochemical changes in blood serum. Background: Alzheimer’s disease presents significant diagnostic challenges, often requiring invasive or costly procedures with limited early detection capabilities....
Published: 5/6/2026   |   Updated: 5/4/2026   |   Inventor(s): Igor Lednev
Keywords(s): Alzheimer's, blood, diagnostics, neurodegeneration, Raman spectroscopy, statistical analysis, TAF, Technologies, vibrational spectroscopy
Category(s): Technology Classifications > Diagnostics, Campus > University at Albany
Inclusion Body–Based Expression Platform for PTM-Preserved Proteins (PIInBody)
Enables high-yield production of unstable, post-translationally modified proteins by protecting them during expression and gentle release Background Intrinsically disordered proteins (IDPs), particularly those carrying labile post-translational modifications (PTMs), are difficult to produce recombinantly due to degradation, aggregation, and loss...
Published: 5/9/2026   |   Updated: 2/19/2026   |   Inventor(s): Richard Cooley, Cat Vesely, Ryan Mehl
Keywords(s): antibody, architecture, assay, assay development, bacterial, bacterial expression system, binders, cancer, code, denaturing, diagnostic, drug development, enzymatic, epitope, expression platform, expression system, fusion, homogeneous, inclusion, isotopic, isotopic labeling, mass spectrometry, neurodegeneration, post-translational, protein, purification, reagent, recombinant, screening assays, structural biology
Category(s): Biological Materials
Novel three-dimensional, conformal microelectrode arrays for interrogating and manipulating three-dimensional cell culture systems
A flexible, biocompatible microelectrode array wraps around 3D cell cultures such as organoids, enabling comprehensive electrical recording and stimulation for advanced research, drug testing, and personalized medicine, overcoming the limitations of traditional flat electrode arrays. Background: Three-dimensional (3D) cell culture systems, such as...
Published: 2/18/2026   |   Updated: 1/26/2026   |   Inventor(s): Susan Sharfstein, Nathaniel Cady, Yubing Xie, Natalya Tokranova, Anthony Manning, Fernando Pesantez Torres
Keywords(s): 3D culture, 3D flexible microelectrode, electrophysiology, microelectrode array, microfabrication, neurodegeneration, organoid, polymer materials, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering
Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)
Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...
Published: 8/21/2025   |   Updated: 1/17/2024   |   Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu Zheng
Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers
Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease
Use of Neurotrophic Factor-alpha1/Carboxypeptidase E (CPE) to Treat Alzheimer Disease
Summary: The NICHD is seeking licensees for development of Carboxypeptidase E (CPE) as a therapy for MCI or AD. Description of Technology: There is no known cure for Alzheimer’s disease, a brain disorder that severely affects memory, thinking, learning, and organizing skills. It eventually decreases a person’s ability to carry out simple,...
Published: 4/24/2026   |   Updated: 8/2/2023   |   Inventor(s): Yoke Peng Loh, Yong Cheng
Keywords(s): “Cognitive impairment”, Ad, Alzheimer’s Disease, BNDF, brain, Brain-Derived Neurotrophic Factor, Carboxypeptidase E, CPE, Hippocampus, LOH, MCI, MEMORY, Mild Cognitive Impairment, NEURODEGENERATION, NEUROTROPHIC
Category(s): TherapeuticArea > Neurology, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration
Use of Interleukin (IL)-34 to Treat Retinal Inflammation and Neurodegeneration
Abstract: Interleukin (IL)-34 is a homodimer that is produced mainly by keratinocytes, neuronal cells and regulatory T cells (Tregs). It is believed to play important roles in chronic inflammation and the homeostasis of microglia. Currently, there is no effective treatment for many types of retinal degeneration. An improved treatment of autoimmune uveitis...
Published: 4/22/2025   |   Updated: 8/2/2023   |   Inventor(s): Rachel Caspi, Mary Mattapallil, Zhijian Wu
Keywords(s): AAV Vector, Caspi, GENE THERAPY, IL-34, inflammatory disease, Inherited Retinal Dystrophies, Interleukin 34, National Eye Institute, NEI, NEURODEGENERATION, Photoreceptor Death, Retinal degeneration, Retinal Inflammation, uveitis
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology
2021-278 Enhancement of Human Memory and Treatment of Alzheimer’s Disease by Closed -Loop Phase-Locked Brain Electric Stimulation During Sleep
­SUMMARY: UCLA researchers in the department of Neurosurgery have developed an implantable brain electrode system which can modulate the brain’s activity to improve sleep and consolidation of memory, several important activities in the treatment of Alzheimer’s Disease. BACKGROUND: Sleep is universally understood to be beneficial to...
Published: 7/17/2025   |   Updated: 6/29/2022   |   Inventor(s): Itzhak Fried, Yuval Nir, Maya Geva-Sagiv
Keywords(s): Deep Brain Stimulation, Deep Brain Stimulation Current Mirror Output Impedance, Electrical Brain Stimulation, Memory, Neurocognitive, Neurodegeneration, Neurodegeneration Alzheimer's Disease Predictive Testing, Neuromodulation, Neurostimulation
Category(s): Medical Devices > Neural Stimulation, Medical Devices > Monitoring And Recording Systems