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Inclusion
Body–Based Expression Platform for PTM-Preserved Proteins (PIInBody)
Enables high-yield production of unstable, post-translationally modified proteins by protecting them during expression and gentle release Background Intrinsically disordered proteins (IDPs), particularly those carrying labile post-translational modifications (PTMs), are difficult to produce recombinantly due to degradation, aggregation, and loss...
Published: 5/9/2026
|
Updated: 2/19/2026
|
Inventor(s):
Richard Cooley
,
Cat Vesely
,
Ryan Mehl
Keywords(s):
antibody
,
architecture
,
assay
,
assay development
,
bacterial
,
bacterial expression system
,
binders
,
cancer
,
code
,
denaturing
,
diagnostic
,
drug development
,
enzymatic
,
epitope
,
expression platform
,
expression system
,
fusion
,
homogeneous
,
inclusion
,
isotopic
,
isotopic labeling
,
mass spectrometry
,
neurodegeneration
,
post-translational
,
protein
,
purification
,
reagent
,
recombinant
,
screening assays
,
structural biology
Category(s):
Biological Materials