Search Results - isotopic

2 Results Sort By:
Inclusion Body–Based Expression Platform for PTM-Preserved Proteins (PIInBody)
Enables high-yield production of unstable, post-translationally modified proteins by protecting them during expression and gentle release Background Intrinsically disordered proteins (IDPs), particularly those carrying labile post-translational modifications (PTMs), are difficult to produce recombinantly due to degradation, aggregation, and loss...
Published: 5/9/2026   |   Updated: 2/19/2026   |   Inventor(s): Richard Cooley, Cat Vesely, Ryan Mehl
Keywords(s): antibody, architecture, assay, assay development, bacterial, bacterial expression system, binders, cancer, code, denaturing, diagnostic, drug development, enzymatic, epitope, expression platform, expression system, fusion, homogeneous, inclusion, isotopic, isotopic labeling, mass spectrometry, neurodegeneration, post-translational, protein, purification, reagent, recombinant, screening assays, structural biology
Category(s): Biological Materials
Non-invasive Isotopic Biomarkers that Predict the Response to Liver Directed Therapy in Methymalonic Acidemia (MMA) and Propionic Acidemia (PA)
Isolated Methylmalonic Acidemia (MMA) comprises a relatively common and heterogeneous group of inborn errors of metabolism. The most common cause of isolated MMA is genetic deficiency of the enzyme methylmalonyl-coA mutase (MUT), which, unfortunately for the affected patients, is also the most clinically severe. NHGRI scientist have invented a series...
Published: 10/28/2024   |   Updated: 12/6/2022   |   Inventor(s): Eirini (Irini) Manoli, Charles Venditti
Keywords(s): Acidemia, Biomarkers, Directed, ISOTOPIC, liver, Methymalonic, MMA, NON-INVASIVE, PREDICT, RESPONSE, That, THERAPY, VPXXXX, WFXXXX, WIXXXX, XCXXXX
Category(s): Application > Occupational Safety and Health, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Dental, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology