Search Results - james+eberwine

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Multipronged Composite Protocol for High-Efficiency Deep Tissue RNA Delivery and Expression
An RNA transfection and protein expression approach comprising lipid nanoparticles, hyaluronic acid, and photostimulation Problem: As the field of cell modification has expanded, researchers have sought more effective methods for nucleic acid (NA) delivery into cells. RNA transfection is easier to facilitate and control than DNA transfection, making...
Published: 5/13/2026   |   Updated: 5/13/2026   |   Inventor(s): James Eberwine, Jai-Yoon Sul, Hyunbum Kim
Keywords(s): Cell Therapy, Gene Editing, Gene Therapy, Platform Technology, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Transcriptome In Vivo Analysis (TIVA)
Technology Overview: Transcriptome in vivo analysis (TIVA) is a novel platform that enables spatial and temporal analysis of the transcriptome in single or multiple cells from a heterogeneous population. TIVA can be combined with numerous in vivo and in vitro functional analysis techniques which are not supported by current RNA isolation methodologies....
Published: 6/7/2024   |   Updated: 6/28/2023   |   Inventor(s): James Eberwine
Keywords(s):  
Category(s): Technology Classifications > Research Tools & Reagents
Tunable, Caged Molecules For In Vivo and In Situ Transcriptomic Analyses
Compounds are designed to detect and characterize specific RNAs in a cell or sub-cellular compartment using light activation. Problem: Cellular RNAs provide critical information on gene expression and regulation. A variety of methods have been developed to isolate mRNA from target cells to understand gene function; however, these methods lack the...
Published: 12/12/2025   |   Updated: 5/18/2023   |   Inventor(s): Ivan Dmochowski, James Eberwine, Sean Yeldell, Julianne Griepenburg, Teresa Rapp, Jennifer Singh, Jai-Yoon Sul, Jae Hee Lee
Keywords(s): Bioengineering, Neurology, Small Molecule
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Chemical Processes and Synthesis