Search Results - samantha+rokey

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Multi-Targeted Kinase Inhibitors Towards AML and Other Cancers
This invention relates to small-molecule compounds that are potential therapeutics for Acute Myeloid Leukemia (AML), specifically AML with the FMS-like tyrosine kinase 3 (FLT3) mutation. The compounds also show activity versus Abl kinases, platelet-derived growth factor receptor (PDGFR), and the dual-specificity tyrosine regulated/Cdc2-like (DYRK/CLK)...
Published: 5/6/2026   |   Updated: 5/6/2026   |   Inventor(s): Christopher Hulme, Alessandra Fistrovich, Samantha Rokey, Aidan McMahon, Timothy Chavez, Jennifer Carew
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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Broad Applications of PROTACS for Targeted Protein Degradation Employing a Molecular Glue-Linker-Warhead Approach
This technology is a high-affinity E3-ligase binder, which has been optimized toward the specific proteolysis targeting chimera (PROTAC) mediated degradation of particular proteins. A PROTAC is a heterobifunctional molecule composed of two active domains and a linker, capable of removing specific unwanted proteins. This technology opens the door for...
Published: 8/27/2025   |   Updated: 2/6/2024   |   Inventor(s): Christopher Hulme, Kevin Schofield, Samantha Rokey, Aidan McMahon, Sean Ginn, Alessandra Fistrovich, Walter Becker, Gerrit Wilms, Katharina Schwandt
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Lens with Electronically Controlled Optical Properties
Executive SummaryThis MSU-developed device allows for electrical control of the optical properties in a liquid lens and other optic devices. Capable of altering light’s focal point, this technology lends itself into many applications such as displays, microscopes, telescopes, interferometers, and many more. Description of TechnologyBy controlling...
Published: 8/20/2022   |   Updated: 4/12/2018   |   Inventor(s): Gary Blanchard, Greg Swain, Romana Jarosova, Ke Ma
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Category(s): Advanced Materials, Chemicals, Devices, Photonics