Search Results - alessandra+fistrovich

2 Results Sort By:
Multi-Targeted Kinase Inhibitors Towards AML and Other Cancers
This invention relates to small-molecule compounds that are potential therapeutics for Acute Myeloid Leukemia (AML), specifically AML with the FMS-like tyrosine kinase 3 (FLT3) mutation. The compounds also show activity versus Abl kinases, platelet-derived growth factor receptor (PDGFR), and the dual-specificity tyrosine regulated/Cdc2-like (DYRK/CLK)...
Published: 5/6/2026   |   Updated: 5/6/2026   |   Inventor(s): Christopher Hulme, Alessandra Fistrovich, Samantha Rokey, Aidan McMahon, Timothy Chavez, Jennifer Carew
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Broad Applications of PROTACS for Targeted Protein Degradation Employing a Molecular Glue-Linker-Warhead Approach
This technology is a high-affinity E3-ligase binder, which has been optimized toward the specific proteolysis targeting chimera (PROTAC) mediated degradation of particular proteins. A PROTAC is a heterobifunctional molecule composed of two active domains and a linker, capable of removing specific unwanted proteins. This technology opens the door for...
Published: 8/27/2025   |   Updated: 2/6/2024   |   Inventor(s): Christopher Hulme, Kevin Schofield, Samantha Rokey, Aidan McMahon, Sean Ginn, Alessandra Fistrovich, Walter Becker, Gerrit Wilms, Katharina Schwandt
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics