Search Results - jennifer+carew

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Multi-Targeted Kinase Inhibitors Towards AML and Other Cancers
This invention relates to small-molecule compounds that are potential therapeutics for Acute Myeloid Leukemia (AML), specifically AML with the FMS-like tyrosine kinase 3 (FLT3) mutation. The compounds also show activity versus Abl kinases, platelet-derived growth factor receptor (PDGFR), and the dual-specificity tyrosine regulated/Cdc2-like (DYRK/CLK)...
Published: 5/6/2026   |   Updated: 5/6/2026   |   Inventor(s): Christopher Hulme, Alessandra Fistrovich, Samantha Rokey, Aidan McMahon, Timothy Chavez, Jennifer Carew
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Monofunctional MDM2 Degraders for Disease Treatment
This invention is for a novel class of MDM2 degraders for treatment of acute myeloid leukemia (AML) and other cancers. This new therapeutic avenue leverages promote ubiquitination of the molecule-MDM2 complex to induce self-degradation in tumors. Background: The American Cancer Society’s estimates for acute myeloid leukemia (AML) in the United...
Published: 3/24/2025   |   Updated: 3/24/2025   |   Inventor(s): Wei Wang, Jennifer Carew, Steffan Nawrocki, Mengyang Chang, Fangchao Bi
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
Innovative Approaches to Optimize the Therapeutic Benefits of Autophagy Inhibition
This technology consists of novel, soluble compounds that are to be used to inhibit autophagy that can lead to pathogenesis of many different diseases and health conditions. Background: Autophagy is the process that regulates the degradation of overabundant malfunctioning cellular components. Autophagy is vital for maintaining cell renewal processes;...
Published: 4/3/2023   |   Updated: 2/22/2022   |   Inventor(s): Jennifer Carew, Steffan Nawrocki, Wei Wang
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules
Innovative Approaches to Optimize the Therapeutic Benefit of Autophagy Inhibition
This invention is a set of novel synthetic compounds that demonstrate autophagy-inhibiting efficacy, useful for cancer and pulmonary hypertension treatment. Background: Autophagy is an evolutionarily conserved lysosomal protein degradation process. Aberrant autophagy plays a role in the pathogenesis of many health conditions including cancer, pulmonary...
Published: 4/3/2023   |   Updated: 10/6/2020   |   Inventor(s): Jennifer Carew, Steffan Nawrocki, Wei Wang
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Therapeutics