Search Results - yong+zeng

4 Results Sort By:
RS-1 Knockout Mouse Model for X-Linked Retinoschisis (XLRS) Research
The National Eye Institute (NEI) seeks research co-development partners and/or licensees for the development of a transgenic mouse model for X-linked retinoschisis (XLRS). This technology includes a transgenic mouse model specifically designed to study X-linked retinoschisis (XLRS) disease by interrupting exon 1 of the Rs1 gene. XLRS is a genetic condition...
Published: 6/24/2026   |   Updated: 6/24/2026   |   Inventor(s): Paul Sieving, Yong Zeng, Ronald Bush
Keywords(s):  
Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Animal Models, TherapeuticArea > Ophthalmology, TherapeuticArea > Rare/Neglected Diseases
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 1/20/2026   |   Updated: 3/4/2025   |   Inventor(s): Yong Zeng, He Yan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics
Enzymatic Reactions for Modifying and Labeling Extracellular Vesicles
Applies Enzymatic Glycan Engineering to Functionalize and Tag Extracellular Vesicles This method for modifying extracellular vesicles combines enzymatic glycan engineering with chemoselective functionalization to unlock applications such as targeted drug delivery. Extracellular vesicles are lipid bilayer-enclosed nanoparticles secreted by cells, acting...
Published: 1/20/2026   |   Updated: 12/2/2024   |   Inventor(s): Zhongwu Guo, Mohit Jaiswal, Yong Zeng, Xin Zhou, Jiatong Guo
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Human Health Care > Diagnostics
Methods and Compositions for Treating Genetically Linked Diseases of the Eye
Abstract: X-linked retinoschisis (XLRS) is an inherited, monogenetic ocular disease caused by mutations in the retinoschisin (RS1) gene, resulting in the development of cystic cavities throughout the retina and leading to juvenile macular degeneration. Approximately 1:15,000 males in the US are affected, classifying the condition as an orphan indication.  The...
Published: 5/15/2025   |   Updated: 8/2/2023   |   Inventor(s): Paul Sieving, Ronald Bush, Yong Zeng, Peter Colosi
Keywords(s): Clinical, EYE, GENE THERAPY, ophthalmological, Orphan Indication, Sieving, XLRS
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology